Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
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Chapter 7, Problem 70P
The combination of photochemotherapy with oral methoxsalen (psoralen) and ultraviolet A radiation (called PUVA treatment) is an effective treatment for psoriasis. However, PUVA is mutagenic, increases the risk of squamous-cell skin cancer. and can cause irregular, pigmented skin lesions. Stern et al. [4] performed a study to assess the incidence of melanoma among patients treated with PUVA. The study identified 1380 patients with psoriasis who were first treated with PUVA in 1975 or 1976. Patients were subdivided according to the total number of treatments received (<250 or >250 from 1975 to 1996). Within each group, the observed number of melanomas was determined from 1975 to 1996 and compared with the expected number of melanomas as determined by published U.S. age- and gender-specific melanoma incidence rates. The results were as in Table 7.8.
Provide a 95% Cl for the expected number of
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The Diabetes Control and Complications trial research group, randomly assigned volunteers with type 1 (insulin-dependent) diabetes mellitus, but without retinopathy, either to a conventional treatment or to a more intensive treatment aimed at maintaining normal blood glucose levels. The volunteers' health was monitored closely for approximately six years. By the end of the study, 91 patients out of 378 in the conventional treatment group had developed retinopathy, whereas 23 out of 348 in the intensive treatment group had developed retinopathy. Test whether the rates of retinopathy differed significantly between the two treatment groups, if they did, which rate was significantly lower.
1. Provide the null hypothesis
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3. calculate the appropriate test statistic. Show all work
4. Identify the p-value for that test statistic
5. Using the p-value method and an alpha level of 0.02 state what your conclusions are regarding the null hypothesis, and…
The Diabetes Control and Complications trial research group, randomly assigned volunteers with type 1 (insulin-dependent) diabetes mellitus, but without retinopathy, either to a conventional treatment or to a more intensive treatment aimed at maintaining normal blood glucose levels. The volunteers' health was monitored closely for approximately six years. By the end of the study, 91 patients out of 378 in the conventional treatment group had developed retinopathy, whereas 23 out of 348 in the intensive treatment group had developed retinopathy. Test wether the rates of retionpathy differed significantly betweenthe two treatment groups, if they did, which rate was significantly lower.
1. Provide the null hypothesis
2. Provide the alternative hypotheses
3. calculate the appropriate test statistic. Show all work
4. Indentify the p-value for that test statistic
5. Using the p-vlaue method and an alpha level of 0.02 state what your conclusions is regarding the null hypothesis, and…
A research on the effect of duodenal infusion of donor feces for recurrent Clostridium difficile examined patients with C. difficile infections which cause persistent diarrhea. Some patients were given the antibiotic vancomycin, while others were given a fecal transplant. At alpha = 0.01, test if the result is dependent on the type of treatment given.
Chapter 7 Solutions
Fundamentals of Biostatistics
Ch. 7.3 - What is the difference between a type I and type...Ch. 7.3 - What is the difference between the critical-value...Ch. 7.3 - Several studies have shown that women with many...Ch. 7.7 - In the BMD study referred to in Case Study 2 (p....Ch. 7.7 - Prob. B.2RECh. 7.7 - Prob. B.3RECh. 7.9 - Prob. C.1RECh. 7.9 - Prob. C.2RECh. 7.9 - How much power did the test in Review Question...Ch. 7 - The mean serum-creatinine level measured in 12...
Ch. 7 - The mean serum-creatinine level measured in 12...Ch. 7 - The mean serum-creatinine level measured in 12...Ch. 7 - The mean serum-creatinine level measured in 1 2...Ch. 7 - The mean serum-creatinine level measured in 12...Ch. 7 - The mean serum-creatinine level measured in 12...Ch. 7 - The mean serumcreatinine level measured in 12...Ch. 7 - The mean serumcreatinine level measured in 12...Ch. 7 - Plasma-glucose levels are used to determine the...Ch. 7 - Plasma-glucose levels are used to determine the...Ch. 7 - Plasma-glucose levels are used to determine the...Ch. 7 - Suppose the incidence rate of myocardial...Ch. 7 - Suppose the incidence rate of myocardial...Ch. 7 - Suppose the incidence rate of myocardial...Ch. 7 - Suppose the incidence rate of myocardial...Ch. 7 - Suppose the incidence rate of myocardial...Ch. 7 - Suppose the annual incidence of asthma in the...Ch. 7 - Prob. 18PCh. 7 - Suppose the annual incidence of asthma in the...Ch. 7 - Prob. 20PCh. 7 - Ribosomal 5S RNA can be represented as a sequence...Ch. 7 - Ribosomal 5S RNA can be represented as a sequence...Ch. 7 - Ribosomal 5S RNA can be represented as a sequence...Ch. 7 - Ribosomal 5S RNA can be represented as a sequence...Ch. 7 - Ribosomal 5S RNA can be represented as a sequence...Ch. 7 - Suppose we identify 50 women 50 to 54 years of age...Ch. 7 - The drug erythromycin has been proposed to...Ch. 7 - A pilot study of a new antihypertensive agent is...Ch. 7 - A pilot study of a new antihypertensive agent is...Ch. 7 - The proportion of deaths due to lung cancer in...Ch. 7 - The proportion of deaths due to lung cancer in...Ch. 7 - The proportion of deaths due to lung cancer in...Ch. 7 - The proportion of deaths due to lung cancer in...Ch. 7 - The proportion of deaths due to lung cancer in...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Iron-deficiency anemia is an important nutritional...Ch. 7 - Suppose a new test is proposed to identify...Ch. 7 - Suppose a new test is proposed to identify...Ch. 7 - Suppose a new test is proposed to identify...Ch. 7 - Suppose a new test is proposed to identify...Ch. 7 - Suppose a new test is proposed to identify...Ch. 7 - The mortality experience of 8146 male employees of...Ch. 7 - The mortality experience of 8146 male employees of...Ch. 7 - The mortality experience of 8146 male employees of...Ch. 7 - The mortality experience of 8146 male employees of...Ch. 7 - Researchers have reported that the incidence rate...Ch. 7 - Researchers have reported that the incidence rate...Ch. 7 - Researchers have reported that the incidence rate...Ch. 7 - Researchers have reported that the incidence rate...Ch. 7 - Left ventricular mass (LVM) is an important risk...Ch. 7 - Left ventricular mass (LVM) is an important risk...Ch. 7 - Left ventricular mass (LVM) is an important risk...Ch. 7 - Left ventricular mass (LVM) is an important risk...Ch. 7 - Prob. 60PCh. 7 - Previous studies have shown that supplementing the...Ch. 7 - Prob. 62PCh. 7 - Prob. 63PCh. 7 - Previous studies have shown that supplementing the...Ch. 7 - Prob. 65PCh. 7 - Prob. 66PCh. 7 - Refer to Data Set NIFED.DAT at...Ch. 7 - The combination of photochemotherapy with oral...Ch. 7 - The combination of photochemotherapy with oral...Ch. 7 - The combination of photochemotherapy with oral...Ch. 7 - Prob. 72PCh. 7 - Breast cancer is strongly influenced by a womans...Ch. 7 - Prob. 74PCh. 7 - An investigator wants to test a new eye drop that...Ch. 7 - Prob. 76PCh. 7 - Table 7.10 gives the itching scores reported by...Ch. 7 - Table 7.10 gives the itching scores reported by...Ch. 7 - Table 7.10 gives the itching scores reported by...Ch. 7 - Table 7.10 gives the itching scores reported by...Ch. 7 - Prob. 81PCh. 7 - Prob. 82PCh. 7 - Concurrent sexual partnerships are widely believed...Ch. 7 - Prob. 84PCh. 7 - Prob. 85PCh. 7 - Prob. 86PCh. 7 - Consider the birthweight data in Example 7.2. What...Ch. 7 - Consider the birthweight data in Example 7.2. Now...Ch. 7 - Prob. 89PCh. 7 - A screening program for neuroblastoma (a type of...Ch. 7 - A screening program for neuroblastoma (a type of...Ch. 7 - Prob. 92PCh. 7 - Prob. 93PCh. 7 - Prob. 94PCh. 7 - Prob. 95PCh. 7 - Prob. 96PCh. 7 - An experiment was performed to assess the efficacy...Ch. 7 - Medical errors are common in hospitals throughout...Ch. 7 - Prob. 99PCh. 7 - Prob. 100PCh. 7 - Prob. 101PCh. 7 - Prob. 102PCh. 7 - Prob. 103PCh. 7 - Prob. 104PCh. 7 - Osteoporosis is an important cause of morbidity in...Ch. 7 - Osteoporosis is an important cause of morbidity in...Ch. 7 - Osteoporosis is an important cause of morbidity in...Ch. 7 - Prob. 108PCh. 7 - Prob. 109PCh. 7 - Prob. 110PCh. 7 - Prob. 111PCh. 7 - Prob. 112PCh. 7 - Prob. 113PCh. 7 - A study was conducted in Sweden to relate the age...Ch. 7 - A study was conducted in Sweden to relate the age...Ch. 7 - A study was conducted in Sweden to relate the age...Ch. 7 - Prob. 117PCh. 7 - Prob. 118PCh. 7 - Prob. 119PCh. 7 - Prob. 120PCh. 7 - Prob. 121P
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