Chapter 9, Problem 34P

Summary Introduction

To analyze:

Table-C contains DNA-sequence information compiled by Marilyn Kozak ($\text{1987}$). The data consists of the percentage of A, C, G and T at each position among the $\text{12}$ nucleotides preceding the start codon in $699$ genes from various vertebrate species and at the first nucleotide after the start codon.(The start codon occupies positions $+1$ to $\text{+3}$, and the first nucleotide immediately after the start codon occupies $\text{+4}$).Use the data to conclude the consensus order for the $\text{13}$ nucleotides ($\text{-12}$ to $\text{-1}$ and $\text{+4}$) surrounding the start codon in vertebrate genes.

Introduction:

Consensus sequences are a short stretch of DNA sequences that are commonly located nucleotides found at a specific location of DNA and RNA. These sequences are used for inter or intramolecular interactions. These sequences are similar in structure and function in all organisms. The consensus sequence is a calculated order that states the most frequent nucleotide at that position in the alignment.