Given this sequence: AUG TAT ACC GAG, which of the following would result in a frameshift mutation? O AUG ACC GAG AUG TAA CCG AG AUG AAA ACC GAG AGG TAT ACC GAG
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Q: If the mutation causing Tay Sachs disease involves a C to T change at position 4 in the sequence…
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- Define and compare the following types of nucleotide substitutions. Which is likely to cause the most dramatic mutant effect? a. missense mutation b. nonsense mutation c. sense mutationConsider this sequence below: GAG TAC ACG AGT GGA Which of the following options is an example of a non-synonymous point mutation? (remember to translate to mRNA!) A. GAG TAC AAT CGA GTG GA B. GAG TAC ACG GGT GGA C. GAG TAC A–G AGT GGA D. GAG TAC ACG AGA GGAIf the mutation causing Tay Sachs disease involves a C to T change at position 4 in the sequence AAGCGTTAGCTAGGCC, what probe would you use to detect the mutation in individuals concerned about carrying the disease?
- ⦁ Original: ATTTGAGCCMutated: ATTGAGCC. This is an example of what kind of mutation?Which of the following set(s) of primers a–d couldyou use to amplify the following target DNA sequence, which is part of the last protein-coding exonof the CFTR gene?5′ GGCTAAGATCTGAATTTTCCGAG ... TTGGGCAATAATGTAGCGCCTT 3′3′ CCGATTCTAGACTTAAAAGGCTC ... AACCCGTTATTACATCGCGGAA 5′a. 5′ GGAAAATTCAGATCTTAG 3′;5′ TGGGCAATAATGTAGCGC 3′b. 5′ GCTAAGATCTGAATTTTC 3′;3′ ACCCGTTATTACATCGCG 5′c. 3′ GATTCTAGACTTAAAGGC 5′;3′ ACCCGTTATTACATCGCG 5′d. 5′ GCTAAGATCTGAATTTTC 3′;5′ TGGGCAATAATGTAGCGC 3′Based on the given description, determine which mutation is being referred to A single base substitution such as UCC --> UGC a. silent b. insertion c. deletion d. transversion e. nonsense f. transition
- Suppose the codon sequence AUGACCCGGCUACUG has a single base pair mutation to AUGACCCGGUUACUG. If the old protein sequence was Met-Thr-Arg-Leu-Leu, what will be the new sequence encoded by the mutant gene?Define FOUR (4) types of point mutations within coding sequencesFor a specific type of mutation at a given location in a particular gene, identify whether it will affect the size of the mRNA, the protein, or both. How would the mutant appear on a gel in comparison to the original
- . A mutational lesion results in a sequence containing amismatched base pair:5′ AGCTGCCTT 3′3′ ACGATGGAA 5′CodonIf mismatch repair occurs in either direction, whichamino acids could be found at this site?Which of the following are safe havens for transposableelement insertions?a. Intronsb. Exonsc. Other transposable elementsd. a and c are both correct.For each of the following sequences, rank them in order (from best to worst) as sequences that could be used to initiate translation according to Kozak’s rules. GACGCCAUGG GCCUCCAUGC GCCAUCAAGG GCCACCAUGG