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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 11, Problem 9QP
Textbook Problem
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Define and compare the following types of nucleotide substitutions. Which is likely to cause the most dramatic mutant effect?

  1. a. missense mutation
  2. b. nonsense mutation
  3. c. sense mutation

Summary Introduction

To explain: The differences and similarities between the missense, nonsense, and sense mutations.

Introduction: Mutation is the change in the original nucleotide sequence of the DNA. During mutation, the nucleotide can be added, deleted, or transformed. A change in the structure of the chromosome also leads to mutation. It can be heritable or non-heritable. If a mutation occurs in somatic cells, it is non-heritable; while a mutation in germ cells is heritable and can affect generations. Mutation leads to different types of cancer.

Explanation of Solution

The similarities between the missense, nonsense, and sense mutation are as follows:

  • These mutations change the nucleotide sequence of the gene.
  • These types of mutation prevent the formation of normal protein.
  • These mutations are the leading cause of genetic diseases and cancer.

The differences between the missense, nonsense, and sense mutations are as follows:

No.

Characteristics

Missense mutation

Nonsense mutationSense mutation
1..Type of changeSingle nucleotide change in the gene.Specific codon of a gene changes into termination codon...
Summary Introduction

To explain: The type of mutation that will have the most dramatic mutant effect.

Introduction: Mutation is the change in the original nucleotide sequence of the DNA. During mutation, the nucleotide can be added, deleted, or transformed. A change in the structure of the chromosome also leads to mutation. It can be heritable or non-heritable. If a mutation occurs in somatic cells, it is non-heritable; while a mutation in germ cells is heritable and can affect generations. Mutation leads to different types of cancer.

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