Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Textbook Question
Chapter 10, Problem 19RQ
Which protein is a positive regulator that phosphorylates other proteins when activated?
- p53
- retinoblastoma protein (Rb)
- cyclin
- cyclin-dependent kinase (Cdk)
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Which of the following are regulators of Cdks?
Choose all that apply. There are 3 correct answers. You will LOSE points (from the total correct) for incorrect answers. This is to discourage guessing.
licensing proteins
activating kinases
cyclins
inhibiting kinases
Rb
Mad and Bub proteins
A cell begins to undergo apoptosis due to stress. Which of the following are true about this cell? (select all that apply)
The cell can exit apoptosis if the stressful factor is removed
The cell has high levels of p53.
The cell's DNA will inevitably degrade
The cell may undergo mitosis before completing apoptosis
Which of the following types of mutations would be most likely to cause cells to undergo apoptosis (programmed cell death)?
One that increases the affinity of p21 for Cdks
One that decreases the affinity of Rb for the transcription factor E2F
One that decreases the ability of p53 to bind to DNA
One that causes p53 to be constitutively phosphorylated
Chapter 10 Solutions
Biology 2e
Ch. 10 - Figure 10.6 Which of the following is the correct...Ch. 10 - Figure 10.13 Rb and other proteins that negatively...Ch. 10 - Figure 10.14 Human papillomavirus can cause...Ch. 10 - A diploid cell has ________ the number of...Ch. 10 - An organism s traits are determined by the...Ch. 10 - The first level of DNA organization in a...Ch. 10 - Identical copies of chromatin held together by...Ch. 10 - S. Chromosomes are duplicated during what stage of...Ch. 10 - Which of the following events does not occur...Ch. 10 - The mitotic spindles arise from which cell...
Ch. 10 - Attachment of the mitotic spindle fibers to the...Ch. 10 - Unpacking of chromosomes and the formation of a...Ch. 10 - Separation of the sister chromatids is a...Ch. 10 - The chromosomes become visible under a light...Ch. 10 - The fusing of Golgi vesicles at the metaplhase...Ch. 10 - At which of the cell-cycle checkpoints do external...Ch. 10 - What is the main prerequisite for clearance at the...Ch. 10 - If the M checkpoint is not cleared, what stage of...Ch. 10 - Which protein is a positive regulator that...Ch. 10 - Many of the negative regulator proteins of the...Ch. 10 - Which negative regulatory molecule can trigger...Ch. 10 - are changes to the order of nucleotides in a...Ch. 10 - A gene that codes for a positive cell-cycle...Ch. 10 - A mutated gene that codes for an altered version...Ch. 10 - Which molecule is a Cdk inhibitor that is...Ch. 10 - Which eukaryotic cell-cycle event is missing in...Ch. 10 - FtsZ proteins direct the formation of a...Ch. 10 - Compare and contrast a human somatic cell to a...Ch. 10 - What is the relationship between a genome,...Ch. 10 - Eukaryotic chromosomes are thousands of times...Ch. 10 - Briefly describe the events that occur in each...Ch. 10 - Chemotherapy drugs such as vincristine (derived...Ch. 10 - Describe the similarities and differences between...Ch. 10 - List some reasons why a cell that has just...Ch. 10 - What cell-cycle events will be affected in a cell...Ch. 10 - Describe the general conditions that must be met...Ch. 10 - Compare and contrast the roles of the positive...Ch. 10 - What steps are necessary for Cdk to become fully...Ch. 10 - Rb is a negative regulator that blocks the cell...Ch. 10 - Outline the steps that lead to a cell becoming...Ch. 10 - Explain the difference between a proto-oncogene...Ch. 10 - List the regulatory mechanisms that might be lost...Ch. 10 - ______ can trigger apoptosis if certain cell-cycle...Ch. 10 - Name the common components of eukaryotic cell...Ch. 10 - Describe how the duplicated bacterial chromosomes...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Which negative regulatory molecule can trigger cell suicide (apoptosis) if vital cell cycle events do not occur? a. p53 b. p21 c. retinoblastoma protein (Rb) d. cyclin-dependent kinase (Cdk)arrow_forwardWhich of the following could be classified as an oncogene? None are possible oncogenes A mutant of MAP kinase that was active with or without being phosphorylated All are possible oncogenes A mutant of MEK with significantly reduced enzyme activity A mutant cAMP phosphodiesterase that made it super-activearrow_forwardWhich molecule is a Cdk inhibitor that is controlled by p53? a. cyclin b. anti-kinase c. Rb d. p21arrow_forward
- Cyclin D/cdk 4,6 inhibits retinoblastoma protein (Rb) binding to...., which ultimately affects gene expression. cycling-dependent kinase tramscription factor E2F p53 oncogenesarrow_forwardWhich of the following must occur for programmed cell death (apoptosis): 1. p53 must be stabilized 2. M-Cdk must be active 3. Caspases must be inactivated 4. There must be local inflammationarrow_forwardIn a healthy cell, which of the following proteins will be activated in order to suppress cell division if the cell is not ready or should not divide? Select one: a. p53 b. cdk c. cyclin d. seperase e. mitogenarrow_forward
- The protein that ensures the fidelity of DNA replication is the a. tumor repressor P53 protein. b. Mitotic arrest deficient protein. c. transcription factor E2F protein. d. Ataxia telangiectasia mutated protein.arrow_forwardWhich of the following demonstrates the link between oncogenes and cancer? The mutations in oncogenes increase the activity or number of molecules that stimulate mitosis, leading to irregular cell division. Oncogenes produce molecules that inhibit mitosis. Oncogenes do not have mutations that increase the activity or number of molecules that stimulate mitosis. Oncogenes are genes that transform tumor cells into normal cells.arrow_forwardIn attempting to design a drug that will impede cell cycle progression in ovarian cancers cells. you will want the drug to have this effect on the cells; Group of answer choices Increase expression of CDK7 Increase the phosphorylation of the ATP-binding pocket of CDK1 Increase expression of CDC25A All of thesearrow_forward
- Which of the following statements about cyclin-dependent kinases (CDKs) is true? CDKs are produced in the cell only in the presence of specific cyclins CDKs are always present in the cell and are always active CDKs are always present in the cell, but are only active in the presence of a specific cyclinarrow_forwardDescribe the effects of the mutation causing the p21 promoter to no longer bind p53 on cell signaling pathways and metabolism or cell cycle control.arrow_forwardWhich is the correct sequence ? 1. protein kinase activated 2. adenylyl cyclase activated 3. produced 4. proteins phosphorylated 5. G protein activatedarrow_forward
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