menu
bartleby
search
close search
Hit Return to see all results
close solutoin list

Questions 4 through 6 refer to the following hypothetical pathway in which substance A is converted to substance C by enzymes 1 and 2. Substance B is the intermediate produced in this pathway: An individual is heterozygous for a recessive mutation in enzyme 1 and heterozygous for a recessive mutation in enzyme 2. This individual marries an individual with the same genotype. List the possible genotypes of their children. For every genotype, determine the activity of enzymes 1 and 2, assuming that the mutant alleles have 0% activity and that each normal allele has 50% activity. For every genotype, determine if compound C will be made. If compound C is not made, list the compound that will be in excess.

BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

Solutions

Chapter
Section
BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 10, Problem 6QP
Textbook Problem
6 views

Questions 4 through 6 refer to the following hypothetical pathway in which substance A is converted to substance C by enzymes 1 and 2. Substance B is the intermediate produced in this pathway:

Chapter 10, Problem 6QP, Questions 4 through 6 refer to the following hypothetical pathway in which substance A is converted

An individual is heterozygous for a recessive mutation in enzyme 1 and heterozygous for a recessive mutation in enzyme 2. This individual marries an individual with the same genotype. List the possible genotypes of their children. For every genotype, determine the activity of enzymes 1 and 2, assuming that the mutant alleles have 0% activity and that each normal allele has 50% activity. For every genotype, determine if compound C will be made. If compound C is not made, list the compound that will be in excess.

Summary Introduction

To determine: The possible genotypes of children born if a individual who is heterozygous for a recessive mutation in enzyme 1 and enzyme 2 marries an individual having the same genotype.

Introduction: Metabolic pathways are catalyzed using enzymes. These enzymes are synthesized based on information provided by the genes.. Any type of change in these genes can hinder the synthesis of these enzymes or lead to synthesis of faulty enzymes. Heterozygosity is when same copies of alleles are present for a gene and homozygosity is when different copies of alleles are present for a gene.

Explanation of Solution

It is given that both the individuals are heterozygous for a recessive mutation of enzymes 1 and 2. To find the possible genotypes of their children, genotypes of parents can be assumed as:

R represents normal enzyme 1 and r shows mutated enzyme 1. D shows normal enzyme 2 and d shows mutated enzyme 2.

Both the parents are heterozygous for the recessive mutation in both the enzymes. So the gametes produced by these parents will be RD, Rd, rD, and rd.

Genotype of the children from these gametes can be determined as follows:

 RDRdrDrd
RDRRDDRRDd
Summary Introduction

To determine: The activity ofenzyme 1 and enzyme 2 for all the genotypes that are produced in children if an individual who is heterozygous for a recessive mutation in both, enzyme 1 and enzyme 2, marries an individual having the same genotype, assuming that there is 0% activity for mutant alleles and 50% activity in normal alleles.

Introduction: Metabolic pathways are catalyzed using enzymes. These enzymes are synthesized based on information provided by the genes.. Any type of change in these genes can hinder the synthesis of these enzymes or lead to synthesis of faulty enzymes. Heterozygosity is when same copies of alleles are present for a gene and homozygosity is when different copies of alleles are present for a gene.

Summary Introduction

To determine: Whether compound C will be made or not in each genotype of children born, if an individual who is heterozygous for a recessive mutation in both, enzyme 1 and enzyme 2, marries an individual having the same genotype, and if compound C not produced, the compounds that will be in excess.

Introduction: Metabolic pathways are catalyzed using enzymes. These enzymes are synthesized based on information provided by the genes.. Any type of change in these genes can hinder the synthesis of these enzymes or lead to synthesis of faulty enzymes. Heterozygosity is when same copies of alleles are present for a gene and homozygosity is when different copies of alleles are present for a gene.

Still sussing out bartleby?

Check out a sample textbook solution.

See a sample solution

The Solution to Your Study Problems

Bartleby provides explanations to thousands of textbook problems written by our experts, many with advanced degrees!

Get Started

Chapter 10 Solutions

Human Heredity: Principles and Issues (MindTap Course List)
Show all chapter solutions
add

Additional Science Textbook Solutions

Find more solutions based on key concepts
Show solutions add
How do eating disorders affect health?

Understanding Nutrition (MindTap Course List)

The senses cannot be completely relied on. Why?

An Introduction to Physical Science

What kind of spectrum does a neon sign produce?

Horizons: Exploring the Universe (MindTap Course List)

The scientific discipline that uses ecological theory to study design, manage, and evaluate productive agricult...

Nutrition: Concepts and Controversies - Standalone book (MindTap Course List)

A solid sphere of radius 40.0 cm has a total positive charge of 26.0 C uniformly distributed throughout its vol...

Physics for Scientists and Engineers, Technology Update (No access codes included)