Genetics: From Genes To Genomes (6th International Edition)
6th Edition
ISBN: 9781260041217
Author: Leland Hartwell Dr., ? Michael L. Goldberg Professor Dr., ? Janice Fischer, ? Leroy Hood Dr.
Publisher: Mcgraw-Hill
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Textbook Question
Chapter 11, Problem 19P
a. | It is possible to perform DNA fingerprinting with SNPs instead of SSRs as DNA markers, but in general you would need to examine more SNP markers than the 13 SSRs used in the CODIS database to be sure of a match. Explain why. |
b. | DNA fingerprinting has been used to verify pedigrees of valuable animals such as show dogs, racing greyhounds, and thoroughbred horses. However, the technology is much harder to apply in these cases than it is in |
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DNA polymorphisms can be used as DNA markers. Describe the differences between SNPs and STR polymorphisms. How can these markers be used for DNA-mapping studies?
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Chapter 11 Solutions
Genetics: From Genes To Genomes (6th International Edition)
Ch. 11 - Choose the phrase from the right column that best...Ch. 11 - Would you characterize the pattern of inheritance...Ch. 11 - Would you be more likely to find single nucleotide...Ch. 11 - A recent estimate of the rate of base...Ch. 11 - If you examine Fig. 11.5 closely, you will note...Ch. 11 - Approximately 50 million SNPs have thus far been...Ch. 11 - Mutations at simple sequence repeat SSR loci occur...Ch. 11 - Humans and gorillas last shared a common ancestor...Ch. 11 - In 2015, an international team of scientists...Ch. 11 - Using PCR, you want to amplify an approximately 1...
Ch. 11 - Prob. 11PCh. 11 - The previous problem raises several interesting...Ch. 11 - You want to make a recombinant DNA in which a PCR...Ch. 11 - You sequence a PCR product amplified from a...Ch. 11 - Prob. 15PCh. 11 - The trinucleotide repeat region of the Huntington...Ch. 11 - Sperm samples were taken from two men just...Ch. 11 - Prob. 18PCh. 11 - a. It is possible to perform DNA fingerprinting...Ch. 11 - On July 17, 1918, Tsar Nicholas II; his wife the...Ch. 11 - The figure that follows shows DNA fingerprint...Ch. 11 - Microarrays were used to determine the genotypes...Ch. 11 - A partial sequence of the wild-type HbA allele is...Ch. 11 - a. In Fig. 11.17b, PCR is performed to amplify...Ch. 11 - The following figure shows a partial microarray...Ch. 11 - Scientists were surprised to discover recently...Ch. 11 - The microarray shown in Problem 25 analyzes...Ch. 11 - The figure that follows shows the pedigree of a...Ch. 11 - One of the difficulties faced by human geneticists...Ch. 11 - Now consider a mating between consanguineous...Ch. 11 - The pedigree shown in Fig. 11.22 was crucial to...Ch. 11 - You have identified a SNP marker that in one large...Ch. 11 - The pedigrees indicated here were obtained with...Ch. 11 - Approximately 3 of the population carries a mutant...Ch. 11 - The drug ivacaftor has recently been developed to...Ch. 11 - In the high-throughput DNA sequencing protocol...Ch. 11 - A researcher sequences the whole exome of a...Ch. 11 - As explained in the text, the cause of many...Ch. 11 - Figure 11.26 portrayed the analysis of Miller...Ch. 11 - A research paper published in the summer of 2012...Ch. 11 - Table 11.2 and Fig. 11.27 together portray the...Ch. 11 - The human RefSeq of the entire first exon of a...Ch. 11 - Mutations in the HPRT1 gene in humans result in at...Ch. 11 - Prob. 44P
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- 4) The government of Iceland has built a database which contains genetic informaiton about individuals using SNP analysis and other methods, which can be used to help diagnose pre-disposition to genetic diseases and other conditions. What are some ethical issues that are raised by compiling such a database?arrow_forwardPedigree Analysis Is a Basic Method in Human Genetic: What does OMIM stand for? What kinds of information are in this database?arrow_forwardPedigree Analysis Is a Basic Method in Human Genetic: What are the reasons that pedigree charts are used?arrow_forward
- Assume that you are working as an expert of karyotype analysis in a Genetics Laboratory. You are using G-Banding for staining to chromosomes. Explain briefly the steps of karyotype analysis from blood samples.arrow_forwardAnswer each of the following correctly. Designer Genes Work (This is all about Applications of Recombinant DNA) 1. How does DNA Replicate? 2. What is Genetically Modified Organism (GMO)? 3. Illustrate your own Designer genes based on the following: 1. Identify a special trait. 2. Identify a source organism. 3. Identify a target orgsnism 4. Identify the modified/added trait.arrow_forwardAnswer the following: 1. Which pieces of DNA are the most informative? Why? 2. Explore the concept of "depth of coverage" (the number of fragments that cover a particular span of the contig). Where is the greatest depth of coverage? Where is the least depth of coverage? 3. What do the patterned bands represent? 4. Was it easier to assemble fragments that had multiple types of markers vs. just one type? Why? Assembling contigs out of DNA sequences (strings of As, Cs, Gs, and Ts) follows the same principle: instead of using markers, you line up fragments by overlapping DNA sequences.arrow_forward
- The figure below represents the size of various SSRS that are used for forensic analysis. The bars corresponding to each locus represent the range of size of the various alleles of the locus. 100 bp 200 bp 300 bp D8S1179 D21S11 D7S820 CSF1PO D3S1358 TH01 D13S317 D16S539 D2S1338 D199433 VWA TPOX D18S51 FGA D5S818 III Each color in the figure represents a set of molecular markers that can be analyzed simultaneously. Which of the following pairs of markers, which are not grouped together in the figure, could be analyzed simultaneously if they were the only two markers being studied? FGA and CSF1PO 400 bp THO and VWA THO and TPOX O TOPX and FGAarrow_forwardDescribe two types of genetic polymorphism that areuseful in DNA typing.arrow_forwardThe following figure shows the FBI-style analysis of the genomic DNA of 10 people (1-10), and also of hair found at a crime scence left by the murderer [***]. This analysis involves the PCR amplification of SSR loci, each from a different (nonhomologus) chromosome. The PCR primers are for each SSR locus are labeled with a unique fluorescent molecule. Some bands are thicker because relatively more of the corresponding PCR product was obtained. The figure has dots aligned on both sides to help you find the crucial bands; it will help to use a straight-edge as a guide. The numbers at right are the total number of copies of the SSR locus among the population of 11 samples. Are any of individuals 1-10 probable relatives of the murderer? If so, identify this person and describe the degree of relationship to the criminal.arrow_forward
- The following figure shows the FBI-style analysis of the genomic DNA of 10 people (1-10), and also of hair found at a crime scence left by the murderer [***]. This analysis involves the PCR amplification of SSR loci, each from a different (nonhomologus) chromosome. The PCR primers are for each SSR locus are labeled with a unique fluorescent molecule. Some bands are thicker because relatively more of the corresponding PCR product was obtained. The figure has dots aligned on both sides to help you find the crucial bands; it will help to use a straight-edge as a guide. The numbers at right are the total number of copies of the SSR locus among the population of 11 samples. e. What is the probability that any random male in USA would share the same genotype as the murderer (the match probability)? Assume that all 11 DNA samples analyzed in the diagram are together representative of the USA population as a whole. Show what numbers you would multiply to do this calculation.arrow_forwardThe following figure shows the FBI-style analysis of the genomic DNA of 10 people (1-10), and also of hair found at a crime scence left by the murderer [***]. This analysis involves the PCR amplification of SSR loci, each from a different (nonhomologus) chromosome. The PCR primers are for each SSR locus are labeled with a unique fluorescent molecule. Some bands are thicker because relatively more of the corresponding PCR product was obtained. The figure has dots aligned on both sides to help you find the crucial bands; it will help to use a straight-edge as a guide. The numbers at right are the total number of copies of the SSR locus among the population of 11 samples. Are any of the loci on the Y chromosome? If so, identify this (these) locus (loci) by color.arrow_forwardAs a technique for detecting genetic variations, RFLP has substantial drawbacks. Name one such drawback, explain why it is unique to RFLP analysis with specific reference to the technique, and discuss why DNA sequencing overcomes this drawback. Please leave the link for any sources used. Thanks!arrow_forward
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