Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 11.7, Problem 1TYK
Summary Introduction
Introduction:
Cancer is a class of diseases that include abnormal growth of cells with the ability to invade or spread to other parts of the body. It differs from the tumors that are benign and do not spread.
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Products of proto-oncogenes and tumor-suppressor genes can be
growth factors and growth factor receptors
signaling molecules like protein kinases
proteins that control DNA repair
transcription factors
all of the above
"In the cellular regulatory pathways that control cell growth and proliferation, the products of oncogenes are stimulatory components and the products of tumor suppressor genes are inhibitory components" is true or false.
Which of these events do you think is likely to promote tumorigenesis in affected cells?
Group of answer choices
DNA methylation of the promoter region of a tumor suppressor gene
Hypermethylation of transcription factors that antagonize Wntsignaling
Open chromatin in the region of of DNA harboring an activating mutation of beta-catenin
All of these
Chapter 11 Solutions
Principles of Biology
Ch. 11.1 - Which of these binding interactions might be...Ch. 11.1 - Prob. 1TYKCh. 11.1 - When an ncRNA functions as a decoy, it contains...Ch. 11.2 - Prob. 1BCCh. 11.2 - Prob. 1CCCh. 11.2 - Prob. 1TYKCh. 11.3 - Prob. 1CCCh. 11.3 - Prob. 1TYKCh. 11.4 - Explain why RISC binds to a specific mRNA. What...Ch. 11.4 - The process of RNA interference may lead to the...
Ch. 11.4 - To catalyze the methylation of an rRNA, a snoRNA...Ch. 11.5 - Prob. 1BCCh. 11.5 - Prob. 1TYKCh. 11.6 - Prob. 1CCCh. 11.6 - Which of the following components are needed for...Ch. 11.6 - Prob. 2TYKCh. 11.7 - Prob. 1TYKCh. 11 - Which of the following types of molecules could...Ch. 11 - Prob. 2TYCh. 11 - Prob. 3TYCh. 11 - Prob. 4TYCh. 11 - Prob. 5TYCh. 11 - Prob. 6TYCh. 11 - Prob. 7TYCh. 11 - Prob. 8TYCh. 11 - Prob. 9TYCh. 11 - Prob. 10TYCh. 11 - An ncRNA may have the following funtions:...Ch. 11 - Prob. 2CCQCh. 11 - Prob. 3CCQCh. 11 - Review the concept of an RNA world described in...Ch. 11 - Prob. 2CBQ
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- Which of the following mutations will result in cancer? a. homozygous recessive mutation in a tumor-suppressor gene coding for a nonfunctional protein b. dominant mutation in a tumor-suppressor gene in which the normal protein product is overexpressed c. homozygous recessive mutation in which there is a deletion in the coding region of a proto-oncogene, leaving it nonfunctional d. dominant mutation in a proto-oncogene in which the normal protein product is overexpressedarrow_forwardExplain the difference between a proto-oncogene and a tumor suppressor gene.arrow_forwardDescribe, using specific examples, the differences in how a growth factor gene and a tumor suppressor gene can become oncogenes.arrow_forward
- Which of the following is not a tumor suppressor gene? a.RET b.RB c.BRCA1 d.BRCA2arrow_forwardWhich of the following is not an example of tumor-suppressor gene? A. p53 gene B. Rb gene C. DCC gene D. Ras GTPase it is not carrow_forwardIn some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an oncogene or a tumor-suppressor gene? Explain your reasoningarrow_forward
- Which of the following types of mutations would be advantageous to a cancer cell (select all that apply)? A. An inactivating mutation in a tumor suppressor gene B. Methylation of the promoter of a tumor suppressor gene C. An inactivating mutation in an oncogene D. Mutation that inactivated DNA repair gene E. An inactivating mutation in an oncogenearrow_forwardWhich of the following statements correctly describes a characteristic of tumor-suppressor gene? a) they are frequently overexpressed in cancerous cells. b) they are cancer-causing genes introduced into cells by viruses. c) they encode proteins that help prevent uncontrolled cell growth. d) they often encode proteins that stimulate the cell cycle.arrow_forwardCompare and contrast oncogenes and tumor suppressors. Contrast oncogenes and proto-oncogenes. Describe the types of mutations that convert proto-oncogenes into oncogenes. Summarize some functions of common oncogenes in cell survival and uncontrolled growth. Contrast tumor suppressors to oncogenes. Describe the types of mutations in tumor suppressors that are found in common cancers. Summarize the functions of common tumor suppressors in cell survival and cell growth.arrow_forward
- Describe the difference between a tumor suppressor and an oncogene with respect to the actual causes of cancer.arrow_forwardDefine tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene expected to behave as a recessive gene?arrow_forwardAn oncogene is produced from a that has acquired a .a. proto-oncogene, loss-of-function mutationb. proto-oncogene, gain-of-function mutationc. tumor-suppressor gene, loss-of-function mutationd. tumor-suppressor gene, gain-of-function mutationarrow_forward
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