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GENETIC ANALYSIS: AN INTEG. APP. W/MAS
2nd Edition
ISBN: 9781323142790
Author: Sanders
Publisher: Pearson Custom Publishing
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Textbook Question
Chapter 12, Problem 10P
In numerous population studies of spontaneous mutation, two observations are made consistently:
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1a) In a very large population, if the forward and reverse mutation rates are exactly the same, how would you expect the frequency of an original, non-mutated allele to change in the population over time? Will the population eventually achieve an equilibrium value of the frequency of the non-mutated allele?
b) What if the forward mutation rate is one order of magnitude larger (e. 10X) than the reverse mutation rate? Do you expect the frequency of the original, non-mutated allele to increase, decrease, or stay the same over time?
c) If the population size is considerably smaller, does this change your expectations for changes in the frequency of the original, non-mutated allele over several generations?
Consider the following estimates:(a) There are 7 x 109 humans living on this planet.(b) Each individual has about 20,000 (0.2 * 105) genes.(c) The average mutation rate at each locus is 10-5.How many spontaneous mutations are currently present inthe human population? Assuming that these mutations areequally distributed among all genes, how many new mutationshave arisen in each gene in the human population?
A neutral mutation arises in a diploid population of 10,000 individuals. Use this information to answer the following questions.
a)
What is the probability that the neutral allele goes to fixation?
b)
Assuming that the neutral mutation eventually goes to fixation, what is the expected time to fixation (in generations)?
Chapter 12 Solutions
GENETIC ANALYSIS: AN INTEG. APP. W/MAS
Ch. 12 - 11.1 Identify two general ways chemical mutagens...Ch. 12 - 11.2 Nitrous acid and (BU) alter DNA by different...Ch. 12 - 11.19 Using the adeninethymine base pair in this...Ch. 12 - The partial amino acid sequence of a wild-type...Ch. 12 - 5. Thymine is usually in its normal, common form....Ch. 12 - Ultraviolet (UV) radiation is mutagenic.
What...Ch. 12 - Researchers interested in studying mutation and...Ch. 12 - The effect of base - pair substitution mutations...Ch. 12 - Prob. 9PCh. 12 - 11.10 In numerous population studies of...
Ch. 12 - 11.11 Two different mutations are identified in a...Ch. 12 - 11.22 Many human genes are known to have homologs...Ch. 12 - 11.13 Answer the following questions concerning...Ch. 12 - Prob. 14PCh. 12 - Prob. 15PCh. 12 - Prob. 16PCh. 12 - 11.15 A sample of the bacterium is exposed to...Ch. 12 - 11.16 A strain of is identified as having a null...Ch. 12 - Define gene conversion and contrast it with gene...Ch. 12 - Prob. 20PCh. 12 - Prob. 21PCh. 12 - Prob. 22PCh. 12 - Prob. 23PCh. 12 - Prob. 24PCh. 12 - 25. If homologous recombination did not occur,...Ch. 12 - In this chapter, three features of genes or of DNA...Ch. 12 - Briefly compare the production of DNA double -...Ch. 12 - During mismatch repair, why is it necessary to...Ch. 12 - 11.27 Following the spill of a mixture of...Ch. 12 - A geneticist searching for mutations uses the...Ch. 12 - A wild - type culture of haploid yeast is exposed...Ch. 12 - A fragment of a wild - type polypeptide is...Ch. 12 - Prob. 33PCh. 12 - 11.40 Common baker’s yeast () is normally grown at...Ch. 12 - 11.41 The two gels illustrated below contain...Ch. 12 - Alkaptonuria is a human autosomal recessive...Ch. 12 - 11.33 In an experiment employing the methods of...Ch. 12 - Using your knowledge of DNA repair pathways choose...Ch. 12 - 11.35 Ataxia telangiectasia is a human inherited...Ch. 12 - 40. Two haploid strains of fungus are fused to...
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- What is the key component(s) of usher syndrome.A) The Effect of mutation and Hot-spots of mutation?B) What happens when things go wrong?arrow_forwardHow many different explanations can you think of for the observation that the rate of mutation varies across the genome? How would you weigh up evidence for these different ideas to decide which ones have the most explanatory power?arrow_forwardwhich of the following statements about genome-wide association studies (GWAS) is correct? A) involves scanning the genomes of thousands of unrelated individuals with a particular mutation and comparing them with the genomes of individuals who do not have the mutation. B) involves scanning the genomes of thousands of unrelated individuals with a particular disease and comparing them with the genomes of individuals who do not have the disease C) attempt to identify genes that influence mutation risk D) attempt to identify genes that influence disease risk E) involves scanning the genomes of thousands of unrelated individuals with a particular disease and comparing them with the genomes of individuals who do not have the disease and GWAS attempt to identify genes that influence disease riskarrow_forward
- Achondroplasia is a form of dwarfism that is inherited in humans as an autosomal dominant disorder. A survey in a small country showed that, within a two-year period, there were 24 children with normal parents born with this disorder out of a total of 16,789 births. What is the mutation rate in mutations/locus/generation? answer to the nearest 0.0001.arrow_forwardWhen an Avidian (with a genome size of 50 sites) reproduces with a 10% per site mutation rate, and if the number of mutations per genome is Poisson distributed, then what is the most likely outcome? Possible answers: 4 per genome is most likely, 5 per genome is most likely, 4 mutations per genome and 5 mutations per genome are equally likely, A number other than 4 and/or 5 mutations per genome is most likelyarrow_forwardForward Genetics Analysis uses a variety of beneficial approaches to identify never before described genes. For each of the following approaches or outcomes, briefly (maximum 2 sentences) discuss in your own words, their purpose in Forward Genetics Analysis. c) Mendelian ratios d) Genetic screenarrow_forward
- For three years, Gunther Schlager and Margaret Dickie estimated theforward and reverse mutation rates for five loci in mice that encodevarious aspects of coat color by examining more than 5 million mice forspontaneous mutations (G. Schlager and M. M. Dickie. 1966. Science151:205–206). They detected the following numbers of mutations at thedilute locus: Gametes examined Mutations detectedForwardmutations 260,675 5Reversemutations 583,360 2 Calculate the forward and reverse mutation rates at this locus. If thesemutations rates are representative of rates in natural populations of mice,what would the expected equilibrium frequency of dilute mutations be?arrow_forwardThe table below shows different types of mutations in different positions in four genes. Choose the letter (A to E), from the drop-down menu, that represents the most likely type of protein that will be produced from each of these mutated genes. A: completely normal protein B: functional protein with ONE amino acid different from normal C: non-functional protein with ONE amino acid different from normal D: non-functional protein with MANY amino acids different from normal E: no protein at all Answer Type of mutation Position of mutation in gene (A, B, C, D, or E) before the part of the gene that specifies the active site of the enzyme 2 base pair insertion Inonsense immediately before the stop codon in the part of the gene that specifies the active site of the enzyme silent 1 base pair insertion in an intronarrow_forwardStarting with a population of genetically identical mice, you discover two new independent mutant strains in which all of the animals have epileptic seizures. In both strains, you know that the epileptic seizures are due to a single recessive mutation. You cross a mutant mouse from one strain to a mutant mouse from the second strain and find that none of their many offspring undergo spontaneous seizures. From this experiment you would conclude that the two mutant strains of mice most likely have mutations in: two different genes the same gene, but not necessarily the same DNA base position the same DNA base position within a particular genearrow_forward
- Achondroplasia is a rare form of dwarfism. It is caused by anautosomal dominant mutation within a single gene. Among1,422,000 live births, the number of babies born with achondroplasiawas 31. Among those 31 babies, 18 of them had one parentwith achondroplasia. The remaining babies had twounaffected parents. What is the mutation frequency for this disorderamong these 1,422,000 babies? What is the mutation rate forachondroplasia?arrow_forwardIf every human gamete contains approximately 30,000 genes and if the forward mutation rate is between 1 x 10-5 and 1 x 10-6 new mutations per gene per generation, what is the average number of new mutations per gamete per generation?arrow_forwardThe accompanying photo shows a sequencing gel from the original study that first sequenced the cystic fibrosis gene (J. R. Riordan et al. 1989. Science 245:1066–1073). From the photo, determine the sequence of the normal copy of the gene and the sequence of the mutated copy of the gene. Identify the location of the mutation that causes cystic fibrosis. (Hint: The CF mutation is a 3-bp deletion.)arrow_forward
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