GENETIC ANALYSIS: AN INTEG. APP. W/MAS
2nd Edition
ISBN: 9781323142790
Author: Sanders
Publisher: Pearson Custom Publishing
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Chapter 12, Problem 20P
Summary Introduction
To analyze:
Can the homologous recombination be considereda mutational event that resultsin gene conversion? Write justification for the answer.
Introduction:
Recombination is the exchange of DNA strands, in which new
In homologous recombination, nucleotide sequences are switched between two identical molecules of DNA.
Theunidirectional exchange of nucleotide sequences between similar sequences is gene conversion. In gene conversion, to repair one stretch of sequence, another stretch of arrangement is used as a model.
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In each of the illustrations below, a segment of a chromosome has two copies of a transposable element. In panel a, they are oriented in the same direction, whereas in panel b they are in opposite directions.
A double strand break occurs in element A and is repaired by homologous recombination using element B as a repair template. For each case, what will the chromosome look like after homologous recombination occurs? Choose one of the five options below, 1-5.
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Chapter 12 Solutions
GENETIC ANALYSIS: AN INTEG. APP. W/MAS
Ch. 12 - 11.1 Identify two general ways chemical mutagens...Ch. 12 - 11.2 Nitrous acid and (BU) alter DNA by different...Ch. 12 - 11.19 Using the adeninethymine base pair in this...Ch. 12 - The partial amino acid sequence of a wild-type...Ch. 12 - 5. Thymine is usually in its normal, common form....Ch. 12 - Ultraviolet (UV) radiation is mutagenic.
What...Ch. 12 - Researchers interested in studying mutation and...Ch. 12 - The effect of base - pair substitution mutations...Ch. 12 - Prob. 9PCh. 12 - 11.10 In numerous population studies of...
Ch. 12 - 11.11 Two different mutations are identified in a...Ch. 12 - 11.22 Many human genes are known to have homologs...Ch. 12 - 11.13 Answer the following questions concerning...Ch. 12 - Prob. 14PCh. 12 - Prob. 15PCh. 12 - Prob. 16PCh. 12 - 11.15 A sample of the bacterium is exposed to...Ch. 12 - 11.16 A strain of is identified as having a null...Ch. 12 - Define gene conversion and contrast it with gene...Ch. 12 - Prob. 20PCh. 12 - Prob. 21PCh. 12 - Prob. 22PCh. 12 - Prob. 23PCh. 12 - Prob. 24PCh. 12 - 25. If homologous recombination did not occur,...Ch. 12 - In this chapter, three features of genes or of DNA...Ch. 12 - Briefly compare the production of DNA double -...Ch. 12 - During mismatch repair, why is it necessary to...Ch. 12 - 11.27 Following the spill of a mixture of...Ch. 12 - A geneticist searching for mutations uses the...Ch. 12 - A wild - type culture of haploid yeast is exposed...Ch. 12 - A fragment of a wild - type polypeptide is...Ch. 12 - Prob. 33PCh. 12 - 11.40 Common baker’s yeast () is normally grown at...Ch. 12 - 11.41 The two gels illustrated below contain...Ch. 12 - Alkaptonuria is a human autosomal recessive...Ch. 12 - 11.33 In an experiment employing the methods of...Ch. 12 - Using your knowledge of DNA repair pathways choose...Ch. 12 - 11.35 Ataxia telangiectasia is a human inherited...Ch. 12 - 40. Two haploid strains of fungus are fused to...
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- Based on the attached image, if we are using the Holliday junction model of recombination, where exactly would be the positions where DNA is cut? Would it be to the right because of branch migration?arrow_forwardDescribe two forms of genetic recombination. What functions do they fulfill?arrow_forwardA reciprocal translocation occurs in an individual between chromosomes 4 and 18, and this translocation causes a disease in the individual. What is the most likely reason chromosome mutation causes a disease? a) The translocation causes a break in the chromosome in a gene regulatory region. b) Chromosomes with a translocation cannot replicate. c) An individual with a translocation has some genes duplicated. d) An individual with a translocation has some genes missing.arrow_forward
- A yeast strain with a mutant spo11- allele has been isolated. The mutant allele is nonfunctional; it makes no spo11 protein. What do you suppose is the phenotype of this mutant strain?arrow_forwardIn a transformation experiment involving a wild type bacterial strain with a recipient strain with mutations in genes f, g, h and i pairs of genes were analyzed for co-transformation with the following results: Gene Pair Co-transformation g+ i+ f+ i+ yes no f+ h+ Уes f+ g+ no g+ h+ h+ i+ no уes What is the linear order of these genes relative to cach other?arrow_forwardExplain how exon shuffling can be due to unequal homologous recombination.arrow_forward
- Hydroxylamine (HA) causes only G • C → A • T transitions in DNA. Will HA produce nonsense mutations in wild-type strains?arrow_forwardThe work of McClintock showed that the presence of a transposoncan create a mutable site or locus that is subject to frequent chromosomebreakage. Why do you think a transposon creates a mutable site? If chromosome breakage occurs, do you think the transposon has moved somewhere else? How would you experimentally determine if it has?arrow_forwardIn DNA-hybridization experiments on six species of plants in the genus Vicia, DNA was isolated from each of the six species, denatured by heating, and sheared into small fragments (W. Y. Chooi. 1971. Genetics 68:213–230). In one experiment, DNA from each species and from E. coli was allowed to renature. The graph shows the results of this renaturation experiment. Q. Notice that, for the Vicia species, the rate of renaturation is much faster in the first hour and then slows down. What might cause this initial rapid renaturation and the subsequent slowdown?arrow_forward
- Which of the following statements about linkage disequilibrium is false? a.) A new mutation first exists in a state of perfect, chromosome-wide linkage disequilibrium b.) Linkage disequilibrium is a statistical state detected when two loci segregate independently c.) Linkage disequilibrium is a transient state that can disappear with genetic recombination d.) Physical linkage is required for two loci to be in a state of linkage disequilibrium.arrow_forwardMany transposons move within a genome by replicative mechanisms . They therefore increase in copy number each time they transpose. Although individual transposition events are rare, many transposons are found in multiple copies in genomes. What do you suppose keeps the transposons from completely overrunning their hosts’ genomes?arrow_forwardHow is paramutation similar to normal gene mutation? How does it differ? Make a list of similarities and differences.arrow_forward
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genetic recombination strategies of bacteria CONJUGATION, TRANSDUCTION AND TRANSFORMATION; Author: Scientist Cindy;https://www.youtube.com/watch?v=_Va8FZJEl9A;License: Standard youtube license