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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 12, Problem 23QP
Textbook Problem
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One of the first drugs used for targeted cancer therapy is tamoxifen, used to treat estrogen-receptor breast cancer. In Chapter 10, review the use of this drug. What general conclusions can you draw about targeted drug therapy and genotype?

Summary Introduction

To explain: The general conclusions that can be drawn about targeted drug therapy and genotype.

Introduction: Cancer can be defined as a group of diseases, which involve abnormal growth of cells, and these cells can spread and invade other regions of the body. There are different ways of cancer management such as chemotherapy, radiation therapy, immunotherapy, and laser therapy.

Explanation of Solution

Tamoxifen drug is used in cancer therapy for breast cancer in females. Tamoxifen acts as a substrate and is converted endoxifen by the enzyme CYP2D6. Endoxifen inhibits the functioning of estrogen, which is a factor for breast cancer.

CYP2D6 enzyme is responsible for determining the metabolic rate in converting tamoxifen, and the alleles coding for CYP2D6 is different in different individuals. In some individuals, the enzyme may be more metabolically active whereas in others, the rate of conversion may be slow...

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