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Mike was referred for genetic counseling because he was concerned about his extensive family history of colon cancer. That family history was highly suggestive of hereditary nonpolyposis colon cancer (HNPCC). This predisposition is inherited as an autosomal dominant trait, and those who carry the mutant allele have a 75% chance of developing colon cancer by age 65. Mike was counseled about the inheritance of this condition, the associated cancers, and the possibility of genetic testing (on an affected family member). Mike’s aunt elected to be tested for one of the genes that may be altered in this condition and discovered that she did have an altered MSH2 gene. Other family members are in the process of being tested for this mutation. Is colon cancer treatable? What are the common treatments, and how effective are they?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 12, Problem 3CS
Textbook Problem
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Mike was referred for genetic counseling because he was concerned about his extensive family history of colon cancer. That family history was highly suggestive of hereditary nonpolyposis colon cancer (HNPCC). This predisposition is inherited as an autosomal dominant trait, and those who carry the mutant allele have a 75% chance of developing colon cancer by age 65. Mike was counseled about the inheritance of this condition, the associated cancers, and the possibility of genetic testing (on an affected family member). Mike’s aunt elected to be tested for one of the genes that may be altered in this condition and discovered that she did have an altered MSH2 gene. Other family members are in the process of being tested for this mutation.

Is colon cancer treatable? What are the common treatments, and how effective are they?

Summary Introduction

To determine: Whether colon cancer is treatable or not.

Introduction: Colon cancer is defined as the uncontrolled growth of cells of the large intestine specifically colon, which is the end region of the large intestine. Most colon cancer is benign but in some cases, it can be malignant as well. The cancer property is shown by adenomatous polyps that are cancerous tumors present in the large intestine. Prediagnosis of cancer is necessary for the effective treatment of cancer.

In the given case, Mike has a family history of nonpolyposis colon cancer. 75% of the population inheriting the mutant allele expresses it, and the gene mutation responsible for the colon cancer is present on the MSH2 gene.

Explanation of Solution

Colon cancer is treatable if diagnosed at an earlier stage. The treatment method of colon cancer depends on the size, stage, location a...

Summary Introduction

To determine:  The common treatments for colon cancer and their effectiveness.

Introduction: Prediagnosis is a necessary and important step in the treatment of all type of cancer. At an earlier stage, the cancerous cells are located to a small region and can be treated easily but as the time passes cancer might spread to the other regions of the body, and it becomes more difficult to treat such cancer. Most of the cancers do not show any signs at the early stage of cancer, so genetic studies are important to check the predisposition possibility of a person to develop a particular type of cancer.

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