Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 12, Problem 18QP
You are in charge of a new gene therapy clinic. Two cases have been referred to you for review and possible therapy.
Case 1. A mutation in the promoter of a proto-oncogene causes the gene to make too much of its normal product, a receptor protein that promotes cell division. The uncontrolled cell division has caused cancer.
Case 2. A mutation in an exon of a tumor-suppressor gene makes this gene nonfunctional. The product of this gene normally suppresses cell division. The mutant gene cannot suppress cell division, and this has led to cancer. What treatment options can you suggest for each case?
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Can you match the type of mutations that can occur from the selected below?
a. either proto-oncogene or tumor suppressor gene
b. proto-oncogene
c. tumor suppressor gen
1. Frameshift mutation
2. Missense mutation
3. Nonsense mutation
Discussion: (1 or 2 paragraphs with your own opinion like how Circulating Tumor DNA as Biomarkers for Cancer Detection technology can be early detector of cancer)
Discuss the relationship between protooncogenes and tumor suppressor genes and cancer. ( no intro and please make it short 4-5 sentence) if possible
Chapter 12 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 12.10 - If improved diagnostic tests are developed from...Ch. 12.10 - If you had cancer, would you donate tissue samples...Ch. 12.10 - Prob. 1GRCh. 12.10 - Another model, the random model, proposes that any...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Theodor Boveri predicted that malignancies would...Ch. 12 - Distinguish between a familial and a sporadic...Ch. 12 - Benign tumors: a. are noncancerous growths that do...
Ch. 12 - Prob. 4QPCh. 12 - Prob. 5QPCh. 12 - Prob. 6QPCh. 12 - Prob. 7QPCh. 12 - Prob. 8QPCh. 12 - What is the difference between a proto-oncogene...Ch. 12 - Distinguish between dominant inheritance and...Ch. 12 - Describe the likelihood of developing bilateral...Ch. 12 - Prob. 12QPCh. 12 - The search for the BRCA1 breast cancer gene...Ch. 12 - What are the roles of cellular proto-oncogenes,...Ch. 12 - Which of the following mutations will result in...Ch. 12 - Prob. 16QPCh. 12 - The following family has a history of inherited...Ch. 12 - You are in charge of a new gene therapy clinic....Ch. 12 - Prob. 19QPCh. 12 - Can you postulate a reason or reasons why children...Ch. 12 - Prob. 21QPCh. 12 - In Section 12-1, Julie is concerned that she may...Ch. 12 - Prob. 23QPCh. 12 - What are some factors that epidemiologists have...Ch. 12 - Smoking cigarettes has been shown to be associated...Ch. 12 - Prob. 26QPCh. 12 - Studies have shown that there are significant...
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- are changes to the order of nucleotides in a segment of DNA that codes for a protein. Proto-oncogenes Tumor suppressor genes Gene mutations Negative regulatorsarrow_forwardWhich of the following statements about cancer is false? (a) oncogenes arise from mutations in proto-oncogenes (b) tumor suppressor genes normally interact with growth-inhibiting factors to block cell division (c) more than 120 cancer-driving genes have been discovered (d) oncogenes were first discovered in mouse models for cancer (e) the development of cancer is usually a multistep process involving both oncogenes and mutated tumor suppressor genesarrow_forwardPlease help me with the genomics/developmental biology question below: MatchingA. Proto-oncogenesB. Tumor suppressor genes1. _____ Include stimulators of CDK activity2. _____ Hypermethylation of these genes could contribute to tumor formationarrow_forward
- Which of the following is true of tumor suppressor genes? Group of answer choices a) If this gene is overactive, it becomes an oncogene b) If one of the alleles is mutated, there is usually little effect. Two inactivating mutations are usually required for loss of function (recessive mutation). c) If one copy is lost, the gene no longer functions (dominant mutation) d) Tumor suppressors genes usually cause mitosis or cell growth e) Tumor suppressor genes decrease apoptosisarrow_forwardduring tumor progression, additional mutations occur within multiple cells of a tumor population, leading to multiple different clones of cells within that tumor. Some) but not all) clones may eventually metastasize, depending on the number and type of mutations that occur in those clones. true falsearrow_forwardWhich of the following steps are correct about multistep tumorigenesis (select all that apply)? A. Mutations in progenitor cells are more likely to develop a neoplastic state compared to mutations in stem cells B. Driver mutations give a cell clone a proliferative advanage C. The rate of mutation /genetic change is constant during tumor progression D. Nutrition/diet may effect rate of tumorigenesis E. All cells within a tumor are biologically equivalent and equally capable of high levels proliferationarrow_forward
- one question with multiple parts! 1A) If you were a cancer biologist interested in developing new drugs that will slow down cancer cell metastasis, which of the following strategies would be most effective? a)Develop an activator of mitosis b)Make Her2 protein that is more active on the surface of the cancer cells c) Develop a molecule that increases telomerase activity d) Gene therapy to add a mutated p53 gene to the cancer cells 1B) You are a genetic counsellor, and a couple comes to you with concerns that if they have a child together the child could have the X-linked recessive disease Duchene muscular dystrophy. The man has the disease whereas the woman is a carrier. Which of the following would be a true statement to tell them? a) 100% of their male offspring will likely be carriers of the recessive allele that causes the disease b) 75% of their female offspring will likely be carriers of the recessive allele that causes the disease c) 100% of their male offspring will likely…arrow_forwardTbis a membrane of the family of tumor suppressor genes. true falsearrow_forwardWhich of the following is an application of gene chips? Expression profiling. SNP detection. Tumor classification and analysis. All of these answer choices are correct. Detecting chromosomal abnormalities.arrow_forward
- Carcinogens generate mutations in: Question 17 options: anti-oncogenes and tumor activation genes proto-oncogenes and tumor suppressor genes proto-oncogenes and tumor activation genes anti-oncogenes and tumor suppressor genesarrow_forwardWhich of the following types of mutations would be advantageous to a cancer cell (select all that apply)? A. An inactivating mutation in a tumor suppressor gene B. Methylation of the promoter of a tumor suppressor gene C. An inactivating mutation in an oncogene D. Mutation that inactivated DNA repair gene E. An inactivating mutation in an oncogenearrow_forwardMutations that increase the creation of blood vessels and turn on expression of telomerase are.... Group of answer choices not involved in tumor development. often seen in the very beginning of tumor development. important to help the tumor to continue growing after the cancer has started.arrow_forward
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