Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
expand_more
expand_more
format_list_bulleted
Concept explainers
Textbook Question
Chapter 20, Problem 11P
Two different protein complexes called SCF and APC covalently add a small polypeptide called ubiquitin to cyclin proteins. The addition of ubiquitin to a protein targets that protein to be degraded by another protein complex called the proteasome. The SCF complex is activated during S phase, and the APC complex is activated during M phase.
a. | To which cyclins (A, B, D, or E in Fig. 20.14) do you think SCF couples ubiquitin? What about the APC? |
b. | How might cells activate SCF and APC only at the correct times? |
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Which of the following does NOT pertain to the myoblast-determining gene 1?*a. It is a master gene.b. It is a silencing gene.c. It produces a transactivating protein.d. It activates its own gene.
Gene silencing involves which type of histone modification?*
a. acetylation of histone 4
b. dimethylation of histone 3
c. trimethylation of histone 4
d. trimethylation of histone 3
Given the required environment, the totipotency of the nucleus can allow which of the following?*
a. a committed cell to undergo dedifferentiation
b. a committed cell to undergo terminal differentiation
c. a terminally differentiated cell to produce a complete organism
d. a terminally differentiated cell to produce specific types of tissues
An induced pluripotent cell is described by which of the following?*
a. It is a committed cell that undergoes redifferentiation.
b. It is a committed cell that undergoes dedifferentiation.
c. It is a terminally…
What are the two main functions of the APC / cyclosome complex? Describe in detail.
One change observed at the centrosomes early in mitosis is an increase in the number of γ-TURCcomplexes (which contain γ-tubulin.).How does the presence of γ-tubulin affect the balance between microtubule assembly & disassembly? Why might having more of it present in the centrosomal region be beneficial in the spindle assembly process?
Chapter 20 Solutions
Genetics: From Genes to Genomes
Ch. 20 - For each of the terms in the left column, choose...Ch. 20 - Characterize the differences between tumor cells...Ch. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - A carcinogenic compound is placed on the skin of...Ch. 20 - You have decided to study genetic factors...Ch. 20 - B cells are specialized blood cells that secrete...Ch. 20 - Molecules outside and inside the cell regulate the...Ch. 20 - Put the following steps in the correct ordered...Ch. 20 - a. Would you expect a cell to continue or to stop...
Ch. 20 - Two different protein complexes called SCF and APC...Ch. 20 - One of the hallmarks of mitotic anaphase is the...Ch. 20 - Concerning the Tools of Genetics Box Analysis of...Ch. 20 - Are genome and karyotype instabilities...Ch. 20 - Prob. 15PCh. 20 - Why dont all loss-of-function mutations that are...Ch. 20 - Chromothripsis is a rare phenomenon, first...Ch. 20 - The chromosome 9/22 translocation associated with...Ch. 20 - A female patient 19 years old, whose symptoms are...Ch. 20 - Prob. 20PCh. 20 - A generic signaling cascade is shown in the...Ch. 20 - Neurofibromatosis type 1 NF1; also known as von...Ch. 20 - Families with germ-line BRCA1 or BRCA2...Ch. 20 - The text explained that retroviruses can cause...Ch. 20 - Hepatocellular carcinoma is the most frequent form...Ch. 20 - Suppose that instead of microarrays, you analyzed...Ch. 20 - Prob. 27PCh. 20 - Glioblastoma multiforme GBM is the most common and...Ch. 20 - a. The legend to Fig. 20.29 identifies which of...Ch. 20 - The website CBioPortal http://www.cbioportal.org...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Which ONE of the following is TRUE concerning the so‐called Philadelphia chromosome? Select one: A.It results in loss of BCR serine‐threonine kinase activity B.It leads to generation of a fusion protein with constitutively active tyrosine kinase activity C.It results from a t(8;21) translocation D.Overexpression of the ABL1 gene results from a translocation that brings a strong gene promoter close to the ABL1 genearrow_forwardNewly forming astral microtubules associate with dynein motor proteins, with the tail of the dynein bound to the plasma membrane. This association appears to be important in the distribution of astral microtubules to the polar regions (opposite “ends”) during spindle assembly.Now fast forward to the events of anaphase. In which phase of Anaphase (A or B) does the association between astral microtubules and membrane-bound dynein play a role? What is that role? (Your answer should incorporate information on how the directionality of dynein’s movement is involved in the process you describe.)arrow_forwardIn addition, when ARF is artificially expressed in normal cells, a rapid increase in p53 levels is observed. Studies have demonstrated that ARF, when expressed, is associated with Mdm2. When associated, the two proteins display a particular pattern of localization restricted to the nucleolus. Suggest a mechanism by which ARF leads to p53 build-up.arrow_forward
- The localization of Ase1 and the phenotype of its deletion imply that this protein binds to anti-parallel Microtubules. What would you expect for the organization of a protein that has this property?arrow_forwardwhat are we looking at in part (b)? Is this an11-nm fiber, a 30-nm fiber, or a 300-nm fiber? Does this DNAcome from a cell during M phase or interphase?arrow_forwardThe p53 pathway is important for regulating the cell cycle. In a normal cell, there is a protein called mdm2 that can bind to p53 and deactivate it. A diseased individual has amutation in the gene that codes for mdm2, resulting in an mdm2 protein that is less able to bind to p53. Will this mutation increase, decrease, or cause no change in the rate of cell death? Explain.arrow_forward
- A cell is homozygous for a LOF mutation in the histone acetyltransferase (HAT) gene. Which of the following is/are true? a. Chromatin in the cell will be more condensed than usual, decreasing expression of genes that should be expressed. b. This will lead to histones with more positive charges on their tails, increasing the interaction between histones and the DNA backbone. c. This will lead to a decrease in DNA methylation and therefore cause an increase in gene expression. d. Chromatin in the cell will be less condensed than usual, increasing expression of genes that should not be expressed.arrow_forwardAssume that during the process of creating the SHH protein an error was made. Instead of producing a 462-amino-acid-long protein, you only make a 20-amino-acid-long protein. Assume the error is detected in the Golgi apparatus. Will this protein be exported into the extracellular space? If your answer is no, what will happen to this protein?arrow_forwardExplain why we can say that M-phase of the cell-cycle is triggered by a positive feedback loop. a) What would the consequences be if cohesins were working normally but condensins were not? and b) what stage of the cell cycle would this cause problems in? Why is it important for the centrosome to duplicate during G1-G2 (interphase) before M phase? The kinetochores serve as a link between the sister chromatids and the microtubules attached to the mitotic spindle. a) How are microtubules still able to exhibit dynamic instability after they are bound to the sister chromatids and b) why is this important to mitosis? As the name suggests, the Anaphase-promoting-complex (APC), promotes the 4th phase of mitosis by separating the sister chromatids so they can travel to separate poles of the cell, and prevents them from being re-zipped together. Describe how APC does these two things (Hint: one involves M-cyclin and the other involves…arrow_forward
- In normally dividing cells, once chromosomes have been properly segregated via the steps of mitosis, the two resulting “daughter cells” separate. In animal cells (and other cell types without a cell wall) the contractile ring plays a crucial role in the process of cytokinesis. Exactly how the contractile ring is accurately positioned, so as to be located midway between the two poles (ends) of the dividing cell, is still not fully understood, although factors released from the mitotic spindle are thought to play a role.Regardless of the precise positioning mechanism, one key player in the assembly of the contractile ring is the GTP/GDP binding protein Rho. In its active form, Rho can stimulate the activity of the actin-binding protein formin and (via effects on the myosin regulatory light chain) that of myosin II. Given their respective roles, why might activation of formin and myosin II be beneficial as cells assemble a functional contractile ring structure?arrow_forwardDescribe the roles of p53 and NFAT and their nuclear import. How does the phosphorylation regulate the nuclear import/export of Pho4? Propose an experiment to test this mechanismarrow_forwardIn eukaryotes which of the following combination of chromatin conditions would be most likely to result in the highest levels of expression of gene?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSONBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStaxAnatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
- Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & CompanyLaboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
The Cell Cycle and its Regulation; Author: Professor Dave Explains;https://www.youtube.com/watch?v=eqJqhA8HSJ0;License: Standard YouTube License, CC-BY
Cell Division - Mitosis and Meiosis - GCSE Biology (9-1); Author: Mr Exham Biology;https://www.youtube.com/watch?v=w7vp_uRA8kw;License: Standard YouTube License, CC-BY