Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 20, Problem 4P
Summary Introduction
To determine:
Whether the views regarding germ-line mutations and environmental factors as the cause of cancer conflicting or can be reconciled.
Introduction:
Any abnormal change in the gene sequence is known as mutation. Mutations can lead to various ailments, including cancer. Mutations can lead to uncontrollable growth of the cells leading to the development of cancer.
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Some germ-line mutations predispose individuals tocancer, yet often environmental factors (chemicals,exposure to radiation) are considered major risks fordeveloping cancer. Do these views of the cause ofcancer conflict, or can they be reconciled?
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Chapter 20 Solutions
Genetics: From Genes to Genomes
Ch. 20 - For each of the terms in the left column, choose...Ch. 20 - Characterize the differences between tumor cells...Ch. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - A carcinogenic compound is placed on the skin of...Ch. 20 - You have decided to study genetic factors...Ch. 20 - B cells are specialized blood cells that secrete...Ch. 20 - Molecules outside and inside the cell regulate the...Ch. 20 - Put the following steps in the correct ordered...Ch. 20 - a. Would you expect a cell to continue or to stop...
Ch. 20 - Two different protein complexes called SCF and APC...Ch. 20 - One of the hallmarks of mitotic anaphase is the...Ch. 20 - Concerning the Tools of Genetics Box Analysis of...Ch. 20 - Are genome and karyotype instabilities...Ch. 20 - Prob. 15PCh. 20 - Why dont all loss-of-function mutations that are...Ch. 20 - Chromothripsis is a rare phenomenon, first...Ch. 20 - The chromosome 9/22 translocation associated with...Ch. 20 - A female patient 19 years old, whose symptoms are...Ch. 20 - Prob. 20PCh. 20 - A generic signaling cascade is shown in the...Ch. 20 - Neurofibromatosis type 1 NF1; also known as von...Ch. 20 - Families with germ-line BRCA1 or BRCA2...Ch. 20 - The text explained that retroviruses can cause...Ch. 20 - Hepatocellular carcinoma is the most frequent form...Ch. 20 - Suppose that instead of microarrays, you analyzed...Ch. 20 - Prob. 27PCh. 20 - Glioblastoma multiforme GBM is the most common and...Ch. 20 - a. The legend to Fig. 20.29 identifies which of...Ch. 20 - The website CBioPortal http://www.cbioportal.org...
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- Which of the following statements about cancer is false? (a) oncogenes arise from mutations in proto-oncogenes (b) tumor suppressor genes normally interact with growth-inhibiting factors to block cell division (c) more than 120 cancer-driving genes have been discovered (d) oncogenes were first discovered in mouse models for cancer (e) the development of cancer is usually a multistep process involving both oncogenes and mutated tumor suppressor genesarrow_forwardWhich of the following mutations will result in cancer? a. homozygous recessive mutation in a tumor-suppressor gene coding for a nonfunctional protein b. dominant mutation in a tumor-suppressor gene in which the normal protein product is overexpressed c. homozygous recessive mutation in which there is a deletion in the coding region of a proto-oncogene, leaving it nonfunctional d. dominant mutation in a proto-oncogene in which the normal protein product is overexpressedarrow_forwardDo more mutations necessarily mean that more cancer-causing genes are faulty? Why or why not?arrow_forward
- How mutations, chromosomal changes epigenetics, and environmental agents play roles in the development of cancer ?arrow_forwardDescribe two mechanisms by which genetic change causes cancer.arrow_forwardCan we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb? If so, how is this possible?arrow_forward
- Some cancers show increased incidence with age while others peak at younger ages. Whydo you suppose that some cancers have increased incidence with age while others peak inchildren?arrow_forwardWhat is the difference in an oncogene and tumor suppressor gene and how can each potentially lead to cancer?arrow_forwardThere are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes, and DNA stability/repair genes. Define each of these categories and indicate which one you think the RB1 gene belongs to and why.arrow_forward
- What significance do BRCA1 and BRCA2 have in regard to developing cancer, and what types of cancer are associated with these genes?arrow_forwardEXPLAIN BRIEFLY: Explain the molecular mechanisms of cancers caused by a P53 gene mutation.arrow_forwardExplain the molecular mechanisms of cancers caused by a P53 gene mutation.arrow_forward
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