Genetics: From Genes to Genomes
Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 20, Problem 15P
Summary Introduction

Introduction:

Cancer is referred to a group of diseases that are caused by abnormal cell proliferation with the ability to spread in different parts of the body. Several types of cancer result in the rapid growth of cells, whereas other types of cancer make cells to grow at a slower rate.

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The p53 gene was discovered in 1979, but it was not clear whether the gene functioned as an oncogene or a tumor-suppressor gene. Several years later, researchers showed that both p53 alleles are inactivated in some mouse cancers. This evidence suggests  A. the p53 gene is an oncogene because inactivated alleles would produce mutated signal transduction proteins that would result in stimulating cell division. B. the p53 gene is an oncogene because the cell would overproduce transcription factors to compensate for the inactive alleles, resulting in increased cell division. C. the p53 gene is a tumor-suppressor gene because inactivated alleles indicate a loss of protein function which allowed the cancer to develop D. the p53 gene is a tumor-suppressor gene because the cell would produce too few transcription factors for gene activation, resulting in decreased cell division.
Which of the following statements correctly describes a characteristic of tumor-suppressor gene? a) they are frequently overexpressed in cancerous cells. b) they are cancer-causing genes introduced into cells by viruses. c) they encode proteins that help prevent uncontrolled cell growth. d) they often encode proteins that stimulate the cell cycle.
Which of the following associated with cancer development would you expect to be tumor promoters and not genotoxic carcinogens (select all that apply)?   A. Excessive alcohol consumption that kills liver cells   B. Bisphenol A which mimics the activity of estrogen   C. Chemical in pesticides that binds and activates a transcription factor that cause activation of NFkB   D. Chemical in cigarette smoke that forms adduct with DNA   E.   A viral infection that causes ulcerative coilitis of GI tract

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Genetics: From Genes to Genomes

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