Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 20, Problem 5P
A carcinogenic compound is placed on the skin of inbred laboratory mice. In many of these mice, skin tumors develop at the site of exposure, but only months after the chemical is no longer detectable. Why don’t all the mice develop tumors, and why don’t the tumors appear much sooner?
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Chapter 20 Solutions
Genetics: From Genes to Genomes
Ch. 20 - For each of the terms in the left column, choose...Ch. 20 - Characterize the differences between tumor cells...Ch. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - A carcinogenic compound is placed on the skin of...Ch. 20 - You have decided to study genetic factors...Ch. 20 - B cells are specialized blood cells that secrete...Ch. 20 - Molecules outside and inside the cell regulate the...Ch. 20 - Put the following steps in the correct ordered...Ch. 20 - a. Would you expect a cell to continue or to stop...
Ch. 20 - Two different protein complexes called SCF and APC...Ch. 20 - One of the hallmarks of mitotic anaphase is the...Ch. 20 - Concerning the Tools of Genetics Box Analysis of...Ch. 20 - Are genome and karyotype instabilities...Ch. 20 - Prob. 15PCh. 20 - Why dont all loss-of-function mutations that are...Ch. 20 - Chromothripsis is a rare phenomenon, first...Ch. 20 - The chromosome 9/22 translocation associated with...Ch. 20 - A female patient 19 years old, whose symptoms are...Ch. 20 - Prob. 20PCh. 20 - A generic signaling cascade is shown in the...Ch. 20 - Neurofibromatosis type 1 NF1; also known as von...Ch. 20 - Families with germ-line BRCA1 or BRCA2...Ch. 20 - The text explained that retroviruses can cause...Ch. 20 - Hepatocellular carcinoma is the most frequent form...Ch. 20 - Suppose that instead of microarrays, you analyzed...Ch. 20 - Prob. 27PCh. 20 - Glioblastoma multiforme GBM is the most common and...Ch. 20 - a. The legend to Fig. 20.29 identifies which of...Ch. 20 - The website CBioPortal http://www.cbioportal.org...
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- Suppose you discover a new gene called ABC that contributes to the efficiency of DNA damage repair. You have noticed that cells carrying mutations in this gene stop dividing and go into senescence. Do you think that mutations in this gene can cause cancer? Briefly explain your answer.arrow_forwardHeavy smokers or industrial workers exposed for a limited time to a chemical carcinogen that induces mutations in dna do not usually begin to develop cancers characteristic of their habit or occupation until 10, 20, or even more years after the exposure. suggest an explanation for this long delay.arrow_forwardWhy is it only the risk for cancer that is inherited?arrow_forward
- Which of the following mutations is MOST likely to cause cancer? A) a mutation that causes a cyclin gene to be expressed at all times during the cell cycle B) a mutation that causes an oncogene to be turned off so that no protein is made C) a mutation that causes a Cdk gene to be turned off so that no protein is made D) a mutation that causes a tumor suppressor gene to be over-expressedarrow_forwardAnother model, the random model, proposes that any cell in a malignant tumor has the potential to form a new tumor. Does the cancer stem cell hypothesis contradict this idea?arrow_forwardWhat is cancer? What defects are commonly found in cancer cells? Do all cancer cells have mutations in the same genes? Explain.arrow_forward
- Most forms of cancer are caused by environmental agents that produce mutations in somatic cells. Is an individual with cancer considered a genetic mosaic? Explain why or why not.arrow_forwardHow would you expect the mitotic index of a cancer tissue to compare with that of the onion root tip?arrow_forwardWhat are predisposition genes? why are the responsible for cause of cancer ?arrow_forward
- People who inherit two copies of the BRCA1 mutation are not born with cancer, and some of them never end up developing cancer. Give a possible explanation for why a mutation in a single gene does not always lead to cancer.arrow_forwardDo more mutations necessarily mean that more cancer-causing genes are faulty? Why or why not?arrow_forwardWhich of the following best describes a gene that codes for a tumor-suppressor protein? a. One that helps to prevent progression through the cell cycle. b. One that helps prevent apoptosis. c. One that codes for a DNA repair enzyme. d. One that supports part of a growth factor signaling pathway.arrow_forward
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