Chapter 20, Problem 27P

Summary Introduction

To determine:

The evidence that can be obtained for involving oncogene or tumour suppressor gene in tumorigenesis that is not easy to find from whole-genome sequencing.

Introduction:

The mutations in an oncogene can be considered gain-of-function mutations because proto-oncogenes are abnormally expressed after mutation and turn these genes into oncogenes. The mutations in tumor-suppressor genes can be considered loss-of-function mutations because the expression of tumor suppressor genes is lost, which leads to cancer.