Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 21, Problem 18P
Consider the triangle diagram shown in Fig. 21.15.
| a. | What feature of the genome is likely to be located between the two LD blocks that allows scientists to visualize them as separate blocks? |
| b. | Even though the figure analyzes eight different SNPs, genotyping just two of these SNPs would allow you to predict the genotype of almost everyone in the population. Explain why this limited genotyping has predictive value. |
| c. | When obtaining the data allowing construction of triangular diagrams, have researchers typically genotyped common SNPs or rare SNPs? Explain. |
| d. | Considering your answer to part (b), why are human population geneticists interested in obtaining complete whole-genome sequences, as opposed to genotyping only the small subset of predictive SNPs? |
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The human genome contains more than a million copies of the Alu transposable element. Comparative genomics reveals that the Alu element is found only in the clade of mammals that includes primates, tree shrews,rodents, and rabbits. a. What does the observation that the Alu transposon is limited to this clade reveal about its origin and method of spread among species? b. At many sites in the genome, an Alu element is present in humans but absent in chimpanzees, while at many other sites an Alu element is present in chimpanzees but absent in humans. What are two hypotheses that could explain this situation? For any particular site,how could the hypotheses be distinguished?
a) what feature of the genome is likely to be located between the two LD blocks that allows scientists to visualize them as seperate blocks?
b) Even though the fugure analyzes nine different SNPs, genotyping just two of se SNPs would allow you to predict the genotype of almost everyone in the population. Explain why this limited genotyping has predictive value.
c) When obtaining the data allowing construction of triangular diagrams, have researchers typically genotyped common SNPs or rare SNPs? Explain.
Chapter 21 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 21 - Choose the best matching phrase in the right...Ch. 21 - Prob. 2PCh. 21 - How can each of the following be used in...Ch. 21 - Which of the following statements would be true of...Ch. 21 - Prob. 5PCh. 21 - Prob. 6PCh. 21 - Prob. 7PCh. 21 - Human geneticists have found the Finnish...Ch. 21 - Prob. 9PCh. 21 - Prob. 10P
Ch. 21 - In a certain plant, leaf size is determined by...Ch. 21 - Compare and contrast the use of SNP genotyping: i...Ch. 21 - Prob. 13PCh. 21 - Prob. 14PCh. 21 - Canavan disease, caused by homozygosity for a...Ch. 21 - Prob. 16PCh. 21 - Prob. 17PCh. 21 - Consider the triangle diagram shown in Fig. 21.15....Ch. 21 - Prob. 19PCh. 21 - Prob. 20PCh. 21 - Suppose a GWAS investigation found a particular LD...Ch. 21 - In domesticated dogs, size has a high...Ch. 21 - Prob. 23P
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