Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Videos
Textbook Question
Chapter 5, Problem 36P
A treatment trial is proposed to test the efficacy of vitamin E as a preventive agent for cancer. One problem with such a study is how to assess compliance among participants. A small pilot study is undertaken to establish criteria for compliance with the proposed study agents. In this study, 10 patients are given 400 IU/day of vitamin E and 10 patients are given similar-sized placebo capsules over a 3-month period. Their serum vitamin E levels are measured before and after the 3-month period, and the change (3-month – baseline) is shown in Table 5.2.
Table 5.2 Change in serum vitamin E (mg/dL) in pilot study
Suppose a change of 0.30 mg/dL in serum levels is proposed as a test criterion for compliance; that is, a patient who shows a change of ≥ 0.30 mg/dL is considered a compliant vitamin E taker. If normality is assumed, what percentage of the vitamin E group would be expected to show a change of at least 0.30 mg/dL?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
It is common for baseball pitchers to use stretching to prepare for a game. But does this make a difference? The authors of a paper on the effects of stretching in baseball carried out an experiment to compare two
different types of stretching and a control treatment consisting of no stretching. Participants were adult males with varying levels of baseball throwing experience and who were not professional or collegiate baseball
players. Participants in the two stretching treatments went through a warm-up that included 8 minutes of stretching. Each participant (all three groups) then threw 10 pitches, and the average speed (km/hour) was
calculated.
(a) Explain why it is important that the participants be assigned at random to the three different treatment groups (Stretching Method 1, Stretching Method 2, and No Stretching).
Random assignment ensures that our experiment systematically favors one experimental condition over all others and attempts to create experimental groups that are as…
Have you heard of “pet therapy”? Access to a pet (typically, but not limited to, a dog) has been shown to be associated with beneficial physical responses like lowered blood pressure and reduced anxiety. In a review of the pet therapy literature, Giaquinto and Vlanetini (2009) describe a study that compared two groups of heart patients. Group 1 consisted of patients with high blood pressure and who owned pets. These participants were matched with participants in a control group who also had high blood pressure but did not own pets. Six months later, blood pressure was measured in both groups. Does having a pet reduce blood pressure?
what statistical test should be used and why?
CH2CH3CH4CH5CH6CH7CH8CH9CH10CH11CH12CH13CH14 1P1RQA1RQB1RQC2P2RQA2RQB2RQC3P3RQA3RQB3RQC4P4RQA4RQC5P5RQA6P7P8P9P10P11P12P13P14P15P16P17P18P19P20P21P22P23P24P25P26P27P28P29P30P31P32P33P34P35P36P37P38P39P40P41P42P43P44P45P46P47P48P49P50P51P52P53P54P55P56P57P58P59P60P61P62P63P64P65P66P67P68P69P70P71P72P73P74P75P76P77P78P79P80P81P82P83P84P85P86P87P88P89P90P91P92P93P94P95P96P97P98P99P100P101P102P103P104P105P106P107P108P109P110P111P112P113P114P115P116P117P118P119P120P121P122P123P124P125P126P127P128P129P130P
A treatment trial is proposed to test the efficacy of vitamin E as a preventive agent for cancer. One problem with such a study is how to assess compliance among participants. A small pilot study is undertaken to establish criteria for compliance with the proposed study agents. In this study, 10 patients are given 400 IU/day of vitamin E and 10 patients are given similar-sized placebo capsules over a 3-month period. Their serum vitamin E levels are measured before and after the…
Chapter 5 Solutions
Fundamentals of Biostatistics
Ch. 5.4 - What is the difference between a...Ch. 5.4 - Suppose a continuous random variable can only take...Ch. 5.4 - What is a standard normal distribution?Ch. 5.4 - (a) What is the area to the left of 0.2 under a...Ch. 5.4 - (a) What is z.30? What does it mean? (b) What is...Ch. 5.5 - What is the difference between a standard normal...Ch. 5.5 - What does the principle of standardization mean?Ch. 5.5 - Suppose the distribution of serum-cholesterol...Ch. 5.8 - Why do we use the normal approximation to the...Ch. 5.8 - Prob. C.2RE
Ch. 5.8 - The prevalence of glaucoma among the elderly in...Ch. 5.8 - The number of deaths from heart failure in a...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Suppose that total carbohydrate intake in 12- to...Ch. 5 - Suppose that total carbohydrate intake in 12- to...Ch. 5 - Suppose boys in this age range who live below the...Ch. 5 - Suppose boys in this age range who live below the...Ch. 5 - A study was conducted assessing the effect of...Ch. 5 - A study was conducted assessing the effect of...Ch. 5 - The duration of cigarette smoking has been linked...Ch. 5 - The duration of cigarette smoking has been linked...Ch. 5 - Serum cholesterol is an important risk factor for...Ch. 5 - Serum cholesterol is an important risk factor for...Ch. 5 - Serum cholesterol is an important risk factor for...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - In pharmacologic research a variety of clinical...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - Is the measure in Problem 5.38 a measure of...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - Refer to the pulmonary-function data in the Data...Ch. 5 - Prob. 43PCh. 5 - Refer to the pulmonary-function data in the Data...Ch. 5 - Prob. 45PCh. 5 - A clinical trial was conducted to test the...Ch. 5 - Well-known racial differences in blood pressure...Ch. 5 - Well-known racial differences in blood pressure...Ch. 5 - Prob. 49PCh. 5 - Suppose we observe 84 alcoholics with cirrhosis of...Ch. 5 - What is the probability of observing at least 29...Ch. 5 - Suppose we observe 84 alcoholics with cirrhosis of...Ch. 5 - FIGURE 5.22 Plasma-aldosterone concentrations in...Ch. 5 - FIGURE 5.22 Plasma-aldosterone concentrations in...Ch. 5 - Pregnant women with gestational diabetes mellitus...Ch. 5 - Officials in the State Health Department are...Ch. 5 - Prob. 57PCh. 5 - A study was conducted relating particulate air...Ch. 5 - Prob. 59PCh. 5 - Refer to Data Set VALID.DAT (at...Ch. 5 - Refer to Data Set VALID.DAT (at...Ch. 5 - Prob. 62PCh. 5 - A study concerned the risk of cancer among...Ch. 5 - Prob. 64PCh. 5 - A doctor diagnoses a patient as hypertensive and...Ch. 5 - A doctor diagnoses a patient as hypertensive and...Ch. 5 - Suppose the physician is not sure whether the...Ch. 5 - A study compared different treatments for...Ch. 5 - A study compared different treatments for...Ch. 5 - A study compared different treatments for...Ch. 5 - Obesity is an important determinant of...Ch. 5 - Prob. 72PCh. 5 - Prob. 73PCh. 5 - Prob. 74PCh. 5 - Prob. 75PCh. 5 - Prob. 76PCh. 5 - Answer the question in Problem 5.75 for a binomial...Ch. 5 - Prob. 78PCh. 5 - Prob. 79PCh. 5 - Prob. 81PCh. 5 - Prob. 82PCh. 5 - Prob. 83PCh. 5 - Prob. 85PCh. 5 - Retinitis pigmentosa (RP) is a genetic ocular...Ch. 5 - Prob. 87PCh. 5 - Prob. 88PCh. 5 - Prob. 89PCh. 5 - Physicians recommend that children with type-I...Ch. 5 - Physicians recommend that children with type-I...Ch. 5 - Prob. 92PCh. 5 - Prob. 93PCh. 5 - Prob. 94PCh. 5 - Prob. 95PCh. 5 - A previous study found that people consuming large...Ch. 5 - A previous study found that people consuming large...Ch. 5 - Prob. 98PCh. 5 - A study was recently published in Western...Ch. 5 - Prob. 100PCh. 5 - Prob. 101PCh. 5 - Prob. 102PCh. 5 - Prob. 103PCh. 5 - Prob. 104PCh. 5 - Prob. 105PCh. 5 - What is the 40th percentile of a normal...Ch. 5 - What is the sum of the 40th and 60th percentiles...Ch. 5 - What is z.90?Ch. 5 - A study was performed of different predictors of...Ch. 5 - A study was performed of different predictors of...Ch. 5 - Prob. 111PCh. 5 - Prob. 112PCh. 5 - Cancer The Shanghai Womens Health Study (SWHS) was...Ch. 5 - Prob. 114PCh. 5 - Prob. 115PCh. 5 - Prob. 116PCh. 5 - Prob. 117PCh. 5 - Prob. 118PCh. 5 - Prob. 119PCh. 5 - Prob. 120PCh. 5 - Prob. 121PCh. 5 - Prob. 122PCh. 5 - Prob. 123PCh. 5 - Prob. 124PCh. 5 - Hypertension Blood pressure readings are known to...Ch. 5 - Prob. 126PCh. 5 - Prob. 127PCh. 5 - Prob. 128PCh. 5 - Prob. 129PCh. 5 - Prob. 130P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, statistics and related others by exploring similar questions and additional content below.Similar questions
- Most cases of cervical cancer are linked to a few strains of the human papilloma virus (HPV). The pharmaceutical company Merck developed a vaccine (Gardisil) against these HPV strains. Worldwide clinical trials followed young women after vaccination or administration of placebo for two to four years for signs of HPV-caused cervical cancer. Based on a sample of 100 women in the Gardisil group, 24 % developed cervical cancer, and based on a sample of 100 women in the placebo group, 34 % developed cervical cancer. Test the claim that the proportion of women who developed cervical cancer in the Gardisil group is less than the proportion of women who developed cervical cancer in the placebo group at a = 0.10. Round your answers to three decimal places, and round any interim calculations to four decimal places. Fill in the hypotheses below where p₁ denotes the proportion of women who developed cervical cancer in the Gardisil group and P2 denotes the proportion of women who developed cervical…arrow_forwardMost cases of cervical cancer are linked to a few strains of the human papilloma virus (HPV). The pharmaceutical company Merck developed a vaccine (Gardisil) against these HPV strains. Worldwide clinical trials followed young women after vaccination or administration of placebo for two to four years for signs of HPV-caused cervical cancer. Based on a sample of 100 women in the Gardisil group, 24 % developed cervical cancer, and based on a sample of 100 women in the placebo group, 34 % developed cervical cancer. Test the claim that the proportion of women who developed cervical cancer in the Gardisil group is less than the proportion of women who developed cervical cancer in the placebo group at a = 0.10. Round your answers to three decimal places, and round any interim calculations to four decimal places. Fill in the hypotheses below where p₁ denotes the proportion of women who developed cervical cancer in the Gardisil group and p2 denotes the proportion of women who developed cervical…arrow_forwardMost cases of cervical cancer are linked to a few strains of the human papilloma virus (HPV). The pharmaceutical company Merck developed a vaccine (Gardisil) against these HPV strains. Worldwide clinical trials followed young women after vaccination or administration of placebo for two to four years for signs of HPV-caused cervical cancer. Based on a sample of 100 women in the Gardisil group, 34 % developed cervical cancer, and based on a sample of 100 women in the placebo group, 44% developed cervical cancer. Test the claim that the proportion of women who developed cervical cancer in the Gardisil group is less than the proportion of women who developed cervical cancer in the placebo group at a = 0.05. Round your answers to three decimal places, and round any interim calculations to four decimal places. Fill in the hypotheses below where p₁ denotes the proportion of women who developed cervical cancer in the Gardisil group and p2 denotes the proportion of women who developed cervical…arrow_forward
- Most cases of cervical cancer are linked to a few strains of the human papilloma virus (HPV). The pharmaceutical company Merck developed a vaccine (Gardisil) against these HPV strains. Worldwide clinical trials followed young women after vaccination or administration of placebo for two to four years for signs of HPV-caused cervical cancer. Based on a sample of 100 women in the Gardisil group, 26% developed cervical cancer, and based on a sample 100 women in the placebo group, 32% developed cervical cancer. Test the claim that the proportion of women who developed cervical cancer in the Gardisil group is less than the proportion of women who developed cervical cancer in the placebo group at a = 0.05. Round your answers to three decimal places, and round any interim calculations to four decimal places. Fill in the hypotheses below where p₁ denotes the proportion of women who developed cervical cancer in the Gardisil group and p2 denotes the proportion of women who developed cervical…arrow_forwardMost cases of cervical cancer are linked to a few strains of the human papilloma virus (HPV). The pharmaceutical company Merck developed a vaccine (Gardisil) against these HPV strains. Worldwide clinical trials followed young women after vaccination or administration of placebo for two to four years for signs of HPV-caused cervical cancer. Based on a sample of 100 women in the Gardisil group, 26% developed cervical cancer, and based on a sample of 100 women in the placebo group, 32% developed cervical cancer. Test the claim that the proportion of women who developed cervical cancer in the Gardisil group is less than the proportion of women who developed cervical cancer in the placebo group at a = 0.05. Round your answers to three decimal places, and round any interim calculations to four decimal places. Fill in the hypotheses below where p₁ denotes the proportion of women who developed cervical cancer in the Gardisil group and p2 denotes the proportion of women who developed cervical…arrow_forwardMost cases of cervical cancer are linked to a few strains of the human papilloma virus (HPV). The pharmaceutical company Merck developed a vaccine (Gardisil) against these HPV strains. Worldwide clinical trials followed young women after vaccination or administration of placebo for two to four years for signs of HPV-caused cervical cancer. Based on a sample of 100 women in the Gardisil group, 26% developed cervical cancer, and based on a sample of 100 women in the placebo group, 32% developed cervical cancer. Test the claim that the proportion of women who developed cervical cancer in the Gardisil group is less than the proportion of women who developed cervical cancer in the placebo group at a = 0.05. Round your answers to three decimal places, and round any interim calculations to four decimal places. Fill in the hypotheses below where p₁ denotes the proportion of women who developed cervical cancer in the Gardisil group and p2 denotes the proportion of women who developed cervical…arrow_forward
- You are part of a research team in the newly formed University of California Center for Climate, Health and Equity. The team is interested in studying whether California adults experience levels of inflammation from wildfire smoke that are different compared to the US as a whole. Previous studies reported an average c-reactive protein (CRP) (a measure of systemic inflammation) of 8.2 mg/L among US adults. You obtain a sample of 100 Califor- nia adults and find that their average CRP is 9.0 with a sample standard deviation of 2.0 mg/L. 1.1 State the null and alternative hypotheses using mathematical notation in the context of this question. Но : НА: 1.2 Calculate the 95% confidence interval for the average CRP for California adults. Assume a critical value of 1.98 and round your answer to 2 decimal places. work:arrow_forwardThe death rate per 100,000 for lung cancer is 7 among non-smokers and 71 among smokers. The death rate per 100,000 for coronary thrombosis is 422 among non-smokers and 599 among smokers. The prevalence of smoking in the population is 55%. The relative risk of dying for a smoker compared to a non-smoker is: [Refer to the chapter titled “Study Designs: Cohort Studies”] A. 9.1 for lung cancer and 0.30 for coronary thrombosis. B. 10.1 for lung cancer and 1.4 for coronary thrombosis. C. 10.1 for lung cancer and 8.4 for coronary thrombosis. D. 9.1 for lung cancer and 1.4 for coronary thrombosis. E. 12.4 for lung cancer and 1.7 for coronary thrombosis.arrow_forwardAlthough arsenic is known to be a poison, it also has some beneficial medicinal uses. In one study of the use of arsenic to treat acute promyelocytic leukemia (APL), a rare type if blood cancer, APL patients were given an arsenic compound as part of their treatment. Of those receiving arsenic, 32% were in remission and showed no signs of leukemia in subsequent examination. It is known that 18% of APL patients go into remission after conventional treatment. Suppose that the study had included 100 randomly selected patients. Is there sufficient evidence to conclude that the proportion in remission for the arsenic treatment is greater than 0.18, the remission proportion for conventional treatment? a. Test the hypothesis at the 0.01 significance level. b. Construct and interpret a 99% confidence interval for the true proportion of APL patients who go into remission after using arsenic. Does the inference drawn from this interval match the conclusion from the test that you did in part…arrow_forward
- As men age, their testosterone levels gradually decrease. This may cause a reduction in energy, an increase in fat, and other undesirable changes. Do testosterone supplements reverse some of these effects? A study in the Netherlands assigned 237 men aged 60 to 80 with low or low-normal testosterone levels to either a testosterone supplement or a placebo. Why is it necessary to include a control group in this experiment? Every experiment needs a control group in order to make proper comparisons between treatments. A control group is necessary to balance the effects of other variables among the treatment groups. A control group is necessary so any differences in the effects of the treatments can be distinguished from chance differences between the groups. A control group helps avoid confounding and reduces variability in the response variable. A control group is used to provide a baseline for comparing the effects of other treatments.arrow_forwardStatistics Questionarrow_forwardCash flow and profits are both crucial aspects of a business. Profit is the surplus revenue after deducting business expenses. Cash flow is the total amount of cash moving in and out of your business. For a business to be successful in the long term, it needs to generate profits while also operating with positive cash flow. During the Covid-19 pandemic, however, of a random sample of 199 auditors, 104 indicated some measure of agreement with this statement: cash flow is more important to keep the business operating on a day-to-day basis. a) Investigate the claim that one-half of the members of this population would agree with this statement. Also, find and interpret the p-value of this test. b) Find the probability of accepting the claim with a 10%-level test if, in fact, 60% of all auditors agree that cash flow is an important indicator to keep the business operating on a day-to-day basis.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Glencoe Algebra 1, Student Edition, 9780079039897...AlgebraISBN:9780079039897Author:CarterPublisher:McGraw Hill
Glencoe Algebra 1, Student Edition, 9780079039897...
Algebra
ISBN:9780079039897
Author:Carter
Publisher:McGraw Hill
Introduction to experimental design and analysis of variance (ANOVA); Author: Dr. Bharatendra Rai;https://www.youtube.com/watch?v=vSFo1MwLoxU;License: Standard YouTube License, CC-BY