Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Videos
Textbook Question
Chapter 5, Problem 37P
A treatment trial is proposed to test the efficacy of vitamin E as a preventive agent for cancer. One problem with such a study is how to assess compliance among participants. A small pilot study is undertaken to establish criteria for compliance with the proposed study agents. In this study, 10 patients are given 400 IU/day of vitamin E and 10 patients are given similar-sized placebo capsules over a 3-month period. Their serum vitamin E levels are measured before and after the 3-month period, and the change (3-month – baseline) is shown in Table 5.2.
Table 5.2 Change in serum vitamin E (mg/dL) in pilot study
*5.36 Suppose a change of 0.30 mg/dL in serum levels is proposed as a test criterion for compliance; that is, a patient who shows a change of ≥ 0.30 mg/dL is considered a compliant vitamin E taker. If normality is assumed, what percentage of the vitamin E group would be expected to show a change of at least 0.30 mg/dL?
Is the measure in Problem 5.36 a measure of sensitivity, specificity, or predictive value?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
The Diabetes Control and Complications trial research group, randomly assigned volunteers with type 1 (insulin-dependent) diabetes mellitus, but without retinopathy, either to a conventional treatment or to a more intensive treatment aimed at maintaining normal blood glucose levels. The volunteers' health was monitored closely for approximately six years. By the end of the study, 91 patients out of 378 in the conventional treatment group had developed retinopathy, whereas 23 out of 348 in the intensive treatment group had developed retinopathy. Test wether the rates of retionpathy differed significantly betweenthe two treatment groups, if they did, which rate was significantly lower.
1. Provide the null hypothesis
2. Provide the alternative hypotheses
3. calculate the appropriate test statistic. Show all work
4. Indentify the p-value for that test statistic
5. Using the p-vlaue method and an alpha level of 0.02 state what your conclusions is regarding the null hypothesis, and…
Red Wine and Weight LossResveratrol, a compound in grapes and red wine, has been shown to promote weight loss in rodents and now in a primate.1 Lemurs fed a resveratrol supplement for four weeks had decreased food intake, increased metabolic rate, and a reduction in seasonal body-mass gain compared to a control group. Suppose a hypothetical study is done for a different primate species, with one group given a resveratrol supplement and the other group given a placebo. We wish to see if there is evidence that resveratrol increases the mean metabolism rate for this species. (This exercise presents hypothetical data. We will see the results from the actual study later in this chapter.)
(a) State the null and alternative hypotheses.Let group 1 be the species taking a resveratrol supplement and let group 2 be the species taking a placebo.
Cardiovascular disease is a major cause of death and illness worldwide, with high blood pressure and high LDL cholesterol both being established risk factors. Because most cardiovascular events occur in persons with average risk and no previous cardiovascular disease history, the present research examined the simultaneous use of both blood pressure‑reducing drugs and cholesterol‑reducing drugs on this population rather than focus on only those at high risk.
Subjects included men at least 55 years old and women at least 65 years old without cardiovascular disease who had at least one additional risk factor besides age, such as recent or current smoking, hypertension, or family history of premature coronary heart disease. Those with current cardiovascular disease were excluded from the study. Subjects were randomly assigned to the treatment (cholesterol‑ and blood pressure‑reducing drugs) or a placebo, and the number suffering the primary outcome of a fatal cardiovascular event or a…
Chapter 5 Solutions
Fundamentals of Biostatistics
Ch. 5.4 - What is the difference between a...Ch. 5.4 - Suppose a continuous random variable can only take...Ch. 5.4 - What is a standard normal distribution?Ch. 5.4 - (a) What is the area to the left of 0.2 under a...Ch. 5.4 - (a) What is z.30? What does it mean? (b) What is...Ch. 5.5 - What is the difference between a standard normal...Ch. 5.5 - What does the principle of standardization mean?Ch. 5.5 - Suppose the distribution of serum-cholesterol...Ch. 5.8 - Why do we use the normal approximation to the...Ch. 5.8 - Prob. C.2RE
Ch. 5.8 - The prevalence of glaucoma among the elderly in...Ch. 5.8 - The number of deaths from heart failure in a...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Because serum cholesterol is related to age and...Ch. 5 - Suppose that total carbohydrate intake in 12- to...Ch. 5 - Suppose that total carbohydrate intake in 12- to...Ch. 5 - Suppose boys in this age range who live below the...Ch. 5 - Suppose boys in this age range who live below the...Ch. 5 - A study was conducted assessing the effect of...Ch. 5 - A study was conducted assessing the effect of...Ch. 5 - The duration of cigarette smoking has been linked...Ch. 5 - The duration of cigarette smoking has been linked...Ch. 5 - Serum cholesterol is an important risk factor for...Ch. 5 - Serum cholesterol is an important risk factor for...Ch. 5 - Serum cholesterol is an important risk factor for...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - People are classified as hypertensive if their...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - Forced expiratory volume (FEV) is an index of...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - The differential is a standard measurement made...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - In pharmacologic research a variety of clinical...Ch. 5 - Blood Chemistry In pharmacologic research a...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - Is the measure in Problem 5.38 a measure of...Ch. 5 - A treatment trial is proposed to test the efficacy...Ch. 5 - Refer to the pulmonary-function data in the Data...Ch. 5 - Prob. 43PCh. 5 - Refer to the pulmonary-function data in the Data...Ch. 5 - Prob. 45PCh. 5 - A clinical trial was conducted to test the...Ch. 5 - Well-known racial differences in blood pressure...Ch. 5 - Well-known racial differences in blood pressure...Ch. 5 - Prob. 49PCh. 5 - Suppose we observe 84 alcoholics with cirrhosis of...Ch. 5 - What is the probability of observing at least 29...Ch. 5 - Suppose we observe 84 alcoholics with cirrhosis of...Ch. 5 - FIGURE 5.22 Plasma-aldosterone concentrations in...Ch. 5 - FIGURE 5.22 Plasma-aldosterone concentrations in...Ch. 5 - Pregnant women with gestational diabetes mellitus...Ch. 5 - Officials in the State Health Department are...Ch. 5 - Prob. 57PCh. 5 - A study was conducted relating particulate air...Ch. 5 - Prob. 59PCh. 5 - Refer to Data Set VALID.DAT (at...Ch. 5 - Refer to Data Set VALID.DAT (at...Ch. 5 - Prob. 62PCh. 5 - A study concerned the risk of cancer among...Ch. 5 - Prob. 64PCh. 5 - A doctor diagnoses a patient as hypertensive and...Ch. 5 - A doctor diagnoses a patient as hypertensive and...Ch. 5 - Suppose the physician is not sure whether the...Ch. 5 - A study compared different treatments for...Ch. 5 - A study compared different treatments for...Ch. 5 - A study compared different treatments for...Ch. 5 - Obesity is an important determinant of...Ch. 5 - Prob. 72PCh. 5 - Prob. 73PCh. 5 - Prob. 74PCh. 5 - Prob. 75PCh. 5 - Prob. 76PCh. 5 - Answer the question in Problem 5.75 for a binomial...Ch. 5 - Prob. 78PCh. 5 - Prob. 79PCh. 5 - Prob. 81PCh. 5 - Prob. 82PCh. 5 - Prob. 83PCh. 5 - Prob. 85PCh. 5 - Retinitis pigmentosa (RP) is a genetic ocular...Ch. 5 - Prob. 87PCh. 5 - Prob. 88PCh. 5 - Prob. 89PCh. 5 - Physicians recommend that children with type-I...Ch. 5 - Physicians recommend that children with type-I...Ch. 5 - Prob. 92PCh. 5 - Prob. 93PCh. 5 - Prob. 94PCh. 5 - Prob. 95PCh. 5 - A previous study found that people consuming large...Ch. 5 - A previous study found that people consuming large...Ch. 5 - Prob. 98PCh. 5 - A study was recently published in Western...Ch. 5 - Prob. 100PCh. 5 - Prob. 101PCh. 5 - Prob. 102PCh. 5 - Prob. 103PCh. 5 - Prob. 104PCh. 5 - Prob. 105PCh. 5 - What is the 40th percentile of a normal...Ch. 5 - What is the sum of the 40th and 60th percentiles...Ch. 5 - What is z.90?Ch. 5 - A study was performed of different predictors of...Ch. 5 - A study was performed of different predictors of...Ch. 5 - Prob. 111PCh. 5 - Prob. 112PCh. 5 - Cancer The Shanghai Womens Health Study (SWHS) was...Ch. 5 - Prob. 114PCh. 5 - Prob. 115PCh. 5 - Prob. 116PCh. 5 - Prob. 117PCh. 5 - Prob. 118PCh. 5 - Prob. 119PCh. 5 - Prob. 120PCh. 5 - Prob. 121PCh. 5 - Prob. 122PCh. 5 - Prob. 123PCh. 5 - Prob. 124PCh. 5 - Hypertension Blood pressure readings are known to...Ch. 5 - Prob. 126PCh. 5 - Prob. 127PCh. 5 - Prob. 128PCh. 5 - Prob. 129PCh. 5 - Prob. 130P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, statistics and related others by exploring similar questions and additional content below.Similar questions
- Outline the components of the classical experimental design. How is it different from a one-group pre-test post-test design?arrow_forwardA study was conducted to demonstrate that soybeans inoculated with nitrogen-fixing bacteria yield more and grow adequately without expensive environmentally deleterious synthesized fertilizers. The trial was conducted under controlled conditions with uniform amounts of soil. The initial hypothesis was that inoculated plants would outperform their uninoculated counterparts. This assumption is based on the facts that plants need nitrogen to manufacture vital proteins and amino acids and that nitrogen-fixing bacteria would make more of this substance available to plants, increasing their size and yield. There were 8 inoculated plants (I) and 8 uninoculated plants (U). The plant yield as measured by pod weight for each plant is given in Table 2.20 Here are the questions I would like explanations for. Please use STATA to compute answers!!!: 2.35. The objective is to compute appropriate descriptive statistics for I and Data set available U plants. 2.36. Use graphic methods to compare the…arrow_forwardA study was conducted to demonstrate that soybeans inoculated with nitrogen-fixing bacteria yield more and grow adequately without expensive environmentally deleterious synthesized fertilizers. The trial was conducted under controlled conditions with uniform amounts of soil. The initial hypothesis was that inoculated plants would outperform their uninoculated counterparts. This assumption is based on the facts that plants need nitrogen to manufacture vital proteins and amino acids and that nitrogen-fixing bacteria would make more of this substance available to plants, increasing their size and yield. There were 8 inoculated plants (I) and 8 uninoculated plants (U). The plant yield as measured by pod weight for each plant is given in Table 2.20. Compute appropriate descriptive statistics for I and Data set available U plants.arrow_forward
- Does posting calorie content for menu items affectpeople’s choices in fast-food restaurants? According to results obtained by Elbel, Gyamfi, and Kersh(2011), the answer is no. The researchers monitoredthe calorie content of food purchases for children andadolescents in four large fast-food chains before andafter mandatory labeling began in New York City. Although most of the adolescents reported noticing thecalorie labels, apparently the labels had no effect ontheir choices. Data similar to the results obtained showan average of M = 786 calories per meal with s =85 for n =100 children and adolescents before thelabeling, compared to an average of M = 772 calorieswith s = 91 for a similar sample of n = 100 after themandatory posting.a. Use a two-tailed test with a = .05 to determinewhether the mean number of calories after theposting is significantly different than before caloriecontent was posted.b. Calculate r2to measure effect size for the mean difference.arrow_forwardSince its removal from the banned substances list in 2004 by the World Anti-Doping Agency,caffeine has been used by athletes with the expectancy that it enhances their workout andperformance. However, few studies look at the role caffeine plays in sedentary females.Researchers at the University of Western Australia conducted a test in which they determined therate of energy expenditure (kilojoules) on 10 healthy, sedentary females who were nonregularcaffeine users. Each female was randomly assigned either a placebo or caffeine pill (6mg/kg) 60minutes prior to exercise. The subject rode an exercise bike for 15 minutes at 65% of theirmaximum heart rate, and the energy expenditure was measured. The process was repeated on aseparate day for the remaining treatment. The mean difference in energy expenditure (caffeine –placebo) was 18kJ with a standard deviation of 19kJ. If we assume that the differences follow anormal distribution can it be concluded that that caffeine appears to increase…arrow_forwardA magazine reported on the "... treatment-emergent adverse events that occurred in 2% or more patients treated with a new medicine and with incidence greater than placebo in the treatment of depression, OCD, or bulimia." In the study, patients took the new medicine and patients were given placebo. Identify the a. treatment group, b. control group, and c. treatments.arrow_forward
- A case-control study is planned to investigate whether bottle-fed infants are at increased risk of death from acute respiratory infections compared breast-fed infants. The mothers of a group of cases (infants' deaths, with an underlying respiratory cause named on the death certificate) will be interviewed about the breast-feeding status of the child prior to the illness leading to death. The results will be compared to with those obtained from mothers of a group of healthy controls regarding the current breast-feeding status of their infants. It is expected that about 40% of controls will be bottle-fed, and we would like to detect a difference if bottle-feeding was associated with a two-fold increase of death (OR-2). A. How many cases and controls need to be studied to give a 90% power of achieving 5% significance level. Copy and paste/print the answer from the software. B. Repeat part (A) if the OR was three-fold increase. What do you notice about the sample size needed? Explainarrow_forwardA psychologist conducts a 2 x 3 x 2 ANOVA. How many main effects are possible? How many interactions are possible?arrow_forwardWhen evaluating the effectiveness of a newly invented psychological treatment to people having illusions, a psychologist plans to adopt an AB design. Give this psychologist two design recommendations for the evaluation study . Describe what additional design needed to be added to obtain data in evaluating any potential long term effect of the treatmentarrow_forward
- An automotive engineer is investigating two different types of metering devices for an electronic fuel injection system to determine whether they differ in their fuel mileage performance. The system is installed on 10 different cars, and a test is run with each metering device on each car. The data is provided below: Metering Device Car 1 2 1 17.6 16.8 2 19.4 20.0 3 18.2 17.6 4 17.1 16.4 5 15.3 16.0 6 15.9 15.9 7 16.3 16.5 8 18.0 18.4 9 17.3 16.4 10 19.1 20.1 Is there a significant difference between the means of the two metering devices? Use . Interpret the result in the context of the problem. An article in the journal Hazardous Waste and Hazardous Materials (Vol. 6, 1989) reported the results of an analysis of the weight of calcium in standard cement and cement doped with lead. Reduced levels of calcium would indicate that the hydration mechanism in the cement is blocked…arrow_forwardNoting the paucity of information on the effect of estrogen on platelet membrane fatty acid composition, Ranganath et al. (A-48) conducted a study to examine the possibility that changes may be present in postmenopausal women and that these may be reversible with estrogen treatment. The 31 women recruited for the study had not menstruated for at least 3 months or had symptoms of the menopause. No woman was on any form of hormone replacement therapy (HRT) at the time she was recruited. Table 5 shows the platelet membrane linoleic acid values before and after a period of HRT. What is the t critical value? 4 decimal placesarrow_forwardNoting the paucity of information on the effect of estrogen on platelet membrane fatty acid composition, Ranganath et al. (A-48) conducted a study to examine the possibility that changes may be present in postmenopausal women and that these may be reversible with estrogen treatment. The 31 women recruited for the study had not menstruated for at least 3 months or had symptoms of the menopause. No woman was on any form of hormone replacement therapy (HRT) at the time she was recruited. Table 5 shows the platelet membrane linoleic acid values before and after a period of HRT. Does the data follow normal distribution?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
MATLAB: An Introduction with ApplicationsStatisticsISBN:9781119256830Author:Amos GilatPublisher:John Wiley & Sons Inc
Probability and Statistics for Engineering and th...StatisticsISBN:9781305251809Author:Jay L. DevorePublisher:Cengage Learning
Statistics for The Behavioral Sciences (MindTap C...StatisticsISBN:9781305504912Author:Frederick J Gravetter, Larry B. WallnauPublisher:Cengage Learning
Elementary Statistics: Picturing the World (7th E...StatisticsISBN:9780134683416Author:Ron Larson, Betsy FarberPublisher:PEARSON
The Basic Practice of StatisticsStatisticsISBN:9781319042578Author:David S. Moore, William I. Notz, Michael A. FlignerPublisher:W. H. Freeman
Introduction to the Practice of StatisticsStatisticsISBN:9781319013387Author:David S. Moore, George P. McCabe, Bruce A. CraigPublisher:W. H. Freeman
MATLAB: An Introduction with Applications
Statistics
ISBN:9781119256830
Author:Amos Gilat
Publisher:John Wiley & Sons Inc
Probability and Statistics for Engineering and th...
Statistics
ISBN:9781305251809
Author:Jay L. Devore
Publisher:Cengage Learning
Statistics for The Behavioral Sciences (MindTap C...
Statistics
ISBN:9781305504912
Author:Frederick J Gravetter, Larry B. Wallnau
Publisher:Cengage Learning
Elementary Statistics: Picturing the World (7th E...
Statistics
ISBN:9780134683416
Author:Ron Larson, Betsy Farber
Publisher:PEARSON
The Basic Practice of Statistics
Statistics
ISBN:9781319042578
Author:David S. Moore, William I. Notz, Michael A. Fligner
Publisher:W. H. Freeman
Introduction to the Practice of Statistics
Statistics
ISBN:9781319013387
Author:David S. Moore, George P. McCabe, Bruce A. Craig
Publisher:W. H. Freeman
Introduction to experimental design and analysis of variance (ANOVA); Author: Dr. Bharatendra Rai;https://www.youtube.com/watch?v=vSFo1MwLoxU;License: Standard YouTube License, CC-BY