Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Question
Chapter 9, Problem 11RQ
Summary Introduction
To review:
The conditions that indicate low energy status and providedescription of the impact that each of the following conditions will have on flux (through the citric acid cycle):
a. High NADH/NAD+ (Nicotinamide adenine dinucleotide) ratio
b. High ATP/ADP (adenosine triphosphate/adenosine diphosphate) ratio
c. High acetyl-CoA (Coenzyme A) concentration
d. Low citrate concentration
e. High succinyl-CoA concentration.
Introduction:
In mitochondri, aitricacid cycle occurs immediately after glycolysis. It is regulated by the cell’s energyrequirement. When the cellrequires energy, citric acid cycle is stimulate, dhereas it will in inhibited when energy is not needed.
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Chapter 9 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 9 - Prob. 1QCh. 9 - Prob. 2QCh. 9 - Prob. 3QCh. 9 - Prob. 4QCh. 9 - Prob. 5QCh. 9 - Prob. 6QCh. 9 - Prob. 7QCh. 9 - Prob. 1RQCh. 9 - Prob. 2RQCh. 9 - Prob. 3RQ
Ch. 9 - Prob. 4RQCh. 9 - Prob. 5RQCh. 9 - Prob. 6RQCh. 9 - Prob. 7RQCh. 9 - Prob. 8RQCh. 9 - Prob. 9RQCh. 9 - Prob. 10RQCh. 9 - Prob. 11RQCh. 9 - Prob. 12RQCh. 9 - Prob. 13RQCh. 9 - Prob. 14RQCh. 9 - Prob. 15RQCh. 9 - Prob. 16RQCh. 9 - Prob. 17RQCh. 9 - Prob. 18RQCh. 9 - Prob. 19RQCh. 9 - Prob. 20RQCh. 9 - Prob. 21RQCh. 9 - Prob. 22RQCh. 9 - Prob. 23RQCh. 9 - Prob. 24RQCh. 9 - Prob. 25RQCh. 9 - Prob. 26RQCh. 9 - Prob. 27RQCh. 9 - Prob. 28FBCh. 9 - Prob. 29FBCh. 9 - Prob. 30FBCh. 9 - Prob. 31FBCh. 9 - Prob. 32FBCh. 9 - Prob. 33FBCh. 9 - Prob. 34FBCh. 9 - Prob. 35FBCh. 9 - Prob. 36FBCh. 9 - Prob. 37FBCh. 9 - Prob. 38SACh. 9 - Prob. 39SACh. 9 - Prob. 40SACh. 9 - Prob. 41SACh. 9 - Prob. 42SACh. 9 - Prob. 43TQCh. 9 - Prob. 44TQCh. 9 - Prob. 45TQCh. 9 - Prob. 46TQCh. 9 - Prob. 47TQCh. 9 - Prob. 48TQCh. 9 - Prob. 49TQCh. 9 - Prob. 50TQCh. 9 - Prob. 51TQCh. 9 - Prob. 52TQCh. 9 - Prob. 53TQCh. 9 - Prob. 54TQCh. 9 - Prob. 55TQCh. 9 - Prob. 56TQCh. 9 - Prob. 57TQCh. 9 - Prob. 58TQCh. 9 - Prob. 59TQ
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Similar questions
- What two major kinds of chemical reactions occur in the citric acid cycle, and how are these reactions indicated symbolically?arrow_forwardWhat citric acid cycle intermediates would accumulate in the presence of malonate?arrow_forwardWhich reaction in the citric acid cycle is most analogous to the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate? What kind of enzymebound intermediate is formed in both reactions?arrow_forward
- What steps of the citric acid cycle are regulated? How and why are they regulated?arrow_forwardHow is it possible for fluoroacetate to enter the citric acid cycle?arrow_forwardWhat are the two most common inhibitors of stepsof the citric acid cycle and the reaction catalyzed by pyruvatedehydrogenase?arrow_forward
- In eukaryotic cells, the citric acid cycle occurs in the _____________.arrow_forwardWhy is it advantageous for citrate, the product of Reaction 1 of the citric acid cycle, to inhibit phosphofructokinase, which catalyzes the third reaction of glycolysis?arrow_forwardWhat are enzymatic markers within the mitochondria of oxidative metabolismarrow_forward
- The intermediates of glycolysis are phosphorylated, but those of the citric acid cycle are not. Suggest a reason why.arrow_forwardWhat is the reaction catalyzed by glucose 6-phosphatase?arrow_forwardThe citric acid cycle operates only when O2 is present, yet O2 is not a substrate for the cycle. Explain.arrow_forward
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