Life: The Science of Biology
Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 13.2, Problem 3R
Summary Introduction

To review: The interaction between proteins and DNA.

Introduction:

DNA stands for deoxyribonucleic acid and it is known as the genetic material for all the organisms. Proteins play a crucial role in regulating the central dogma, mainly the transcription process of DNA to RNA. It is involved in replication, repair, and packaging process. The proteins and DNA interact during this process and some of them occur in the major groove where the bases are exposed and some occur in the minor groove, which comprises carbohydrate sections of DNA. The structure of the DNA with major and minor grooves are shown below:

Life: The Science of Biology, Chapter 13.2, Problem 3R

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Within a protein, certain amino acids are positively charged (e.g.,lysine and arginine), some are negatively charged (e.g., glutamateand aspartate), some are polar but uncharged, and some are nonpolar.If you knew that a DNA-binding protein was recognizingthe DNA backbone rather than a base sequence, which aminoacids in the protein would be good candidates for interacting withthe DNA?
The underlying structure of DNA is very simple, consisting of only four possible building blocks. a. How is it possible for DNA to carry complex genetic information if its structure is so simple?
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