Genetics: Analysis and Principles
Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 16, Problem 1EQ
Summary Introduction

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The procedure of conducting a cell-fusion experiment for determining the nature of epigenetic modification involved in gene C silencing.

Introduction:

Epigenetics involves the study of genetic modifications that do not take place in DNA (deoxyribonucleic acid) but majorly modify its expression by switching it on or off. These changes can be reversible or irreversible. Some modifications include DNA acetylation or methylation, covalent modification of histone and their localization, chromatin remodeling, and activation of feedback loops, which is achieved using transcription factors and/ or non-coding RNAs (ribonucleic acid).

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What is the key difference between cis- and trans-epigenetic mechanisms for maintaining an epigenetic modification? We considered genomic imprinting of the Igf2 gene, in whichoffspring express the copy of the gene they inherit from their father,but not the copy they inherit from their mother. Is this a cisora trans-epigenetic mechanism?
Using coat color in mice and the development of female honeybees as examples, explain how dietary factors can cause epigenetic modifications, leading to phenotypic effects.
What condition must be fulfilled in order for histone modification to be considered an epigenetic phenomenon? Does DNA methylation meet that criterion? Explain.

Chapter 16 Solutions

Genetics: Analysis and Principles

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