Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 16, Problem 3EQ
Summary Introduction
To review:
5-Azacitidineis an inhibitor of DNA methyltransferase and produces an effect upon its introduction into the pregnant mice. The effect on the coat color of the offspring which is carrying Avy allele.
Introduction:
Epigenetics is defined as astudy ofmechanisms which lead to changes in expression of gene. It is also called epimutation because there is no change in the DNA sequence. However, these changes in the gene expression are passed from one cell to another and are reversible in nature.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
5-azocytidine is an inhibitor of DNA methyltransferases. If this compound was fed to pregnantfemale mouse, how would it affect the coat color of offspring carrying the agouti Avy allele?Explain your answer
Red–green color blindness in humans is due to an X-linked recessive gene. A woman whose father is color blind possesses one eye with normal color vision and one eye with color blindness.
Q. Propose an explanation for this woman’s vision pattern. Assume that no new mutations have spontaneously arisen.
A mutation results in an enzyme that is partially active compared to the wild -type allele. This type of "leaky" mutation
is classified as ________.
A) null/ amorphic
B)hypomorphic
C) hypermorphic
D) neomorphic
E) dominant negative
Chapter 16 Solutions
Genetics: Analysis and Principles
Ch. 16.1 - Which of the following are examples of molecular...Ch. 16.1 - 2. An epigenetic modification to a specific gene...Ch. 16.1 - Prob. 3COMQCh. 16.1 - Epigenetic changes may a. be programmed during...Ch. 16.2 - 1. For the Igf2 gene, where do de novo methylation...Ch. 16.2 - 2. For XCI to occur, where are the Xist and Tsix...Ch. 16.2 - 3. Which of the following possibilities could...Ch. 16.3 - 1. Which of the following statements about...Ch. 16.3 - The effects of paramutation may vary with regard...Ch. 16.4 - 1. When mice carrying theallele exhibit a darker...
Ch. 16.4 - 2. If the VIN3 gene had a loss-of-function...Ch. 16.5 - Prob. 1COMQCh. 16.5 - Prob. 2COMQCh. 16 - Prob. 1CONQCh. 16 - List and briefly describe five types of molecular...Ch. 16 - Prob. 3CONQCh. 16 - What is the key difference between cis and...Ch. 16 - Prob. 5CONQCh. 16 - Prob. 6CONQCh. 16 - 7. Outline the molecular steps in the process of...Ch. 16 - Prob. 8CONQCh. 16 - 9. In general, explain how epigenetic...Ch. 16 - 10. What are the contrasting roles of trithorax...Ch. 16 - Describe the molecular steps by which polycomb...Ch. 16 - Prob. 12CONQCh. 16 - Using coat color in mice and the development of...Ch. 16 - How can environmental agents that do not cause...Ch. 16 - Prob. 15CONQCh. 16 - Prob. 16CONQCh. 16 - Explain how the VIN3/PRC2 complex specifically...Ch. 16 - Prob. 1EQCh. 16 - In the experiments described in Figure 16.8,...Ch. 16 - Prob. 3EQCh. 16 - A research study indicated that an agent in...Ch. 16 - Lets suppose you were interested in developing...Ch. 16 - Prob. 6EQCh. 16 - Prob. 7EQCh. 16 - 2. Discuss the similarities and differences of...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Albinism occurs when cells cannot chemically synthesize pigment molecules. This occurs because the genes encoding the proteins that catalyze those synthesis reactions have sustained mutations. Based on this description, briefly explain whether you think mutations that cause albinism would be more likely to be dominant or recessive.arrow_forwardThe process known as (FILL IN THE BLANK) of the (FILL IN THE BLANK) chromosome in some female cats results in a calico In Rare cases, males can express the calico fur pattern. what would the be genetic explanation for this?arrow_forwardA recessive mutation pd causes purple eyes in Drosophila, in contrast to the wildtype red eyes. A dominant suppressor called Su can restore the color of pd/pd fly eyes to red. If you cross a pd/+ ; Su/+ fly to a pd/pd ; +/+ fly, what proportion of the offspring will have purple eyes?arrow_forward
- To determine whether radiation associated with the atomic bombings of Hiroshima and Nagasaki produced recessive germ-line mutations, scientists examined the sex ratio of the children of the survivors of the blasts. Can you explain why an increase in germ-line mutations might be expected to alter the sex ratio?arrow_forwardHemophilia in humans is due to an X-chromosome mutation. What will be the result of mating a hemophiliac female and male?arrow_forwardThe gene controlling ABO blood type and the gene underlying nail-patella syndrome are said to show linkage. What does that mean in terms of their relative locations in the genome? What does it mean in terms of how the two traits are inherited with respect to each other?arrow_forward
- Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?arrow_forwardIn Section 12.3, ''Laws of Inheritance," an example of epistasis was given for the summer squash. Cross white WAvYy heterozygotes to prove the phenotypic ratio of 12 white:3 yellow:l green that was given in the text.arrow_forwardTheodor Boveri predicted that malignancies would often be associated with chromosomal mutation. What lines of evidence substantiate this prediction?arrow_forward
- There are six types of agglutinogen named C,D, E and c,d,e.the first three are dominant and last three are recessive.discussarrow_forwardThe case of golden labs in which a mutation in a gene for the pigment transport protein results in a lack of pigment (the golden color) instead of the brown or black the results from the actual pigment genes, is an example of... Select one: a. multiple alleles b. epistasis c. genomic imprinting d. altered methylationarrow_forwardColorblindness and hemophilia are both X-linked traits in humans. Explain how a female who has a defective color vision gene on one X chromosome and a defective blood clotting gene causing hemophilia on the other X chromosome can be neither a hemophiliac nor colorblind? Please discuss the effect of Gene dosage compensation in your answer and in your answer describe the molecular process by which this occurs.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage LearningBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY