Genetics: Analysis and Principles
Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 16, Problem 3EQ
Summary Introduction

To review:

5-Azacitidineis an inhibitor of DNA methyltransferase and produces an effect upon its introduction into the pregnant mice. The effect on the coat color of the offspring which is carrying Avy allele.

Introduction:

Epigenetics is defined as astudy ofmechanisms which lead to changes in expression of gene. It is also called epimutation because there is no change in the DNA sequence. However, these changes in the gene expression are passed from one cell to another and are reversible in nature.

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5-azocytidine is an inhibitor of DNA methyltransferases. If this compound was fed to pregnantfemale mouse, how would it affect the coat color of offspring carrying the agouti Avy allele?Explain your answer
Red–green color blindness in humans is due to an X-linked recessive gene. A woman whose father is color blind possesses one eye with normal color vision and one eye with color blindness.   Q. Propose an explanation for this woman’s vision pattern. Assume that no new mutations have spontaneously arisen.
A mutation results in an enzyme that is partially active compared to the wild -type allele. This type of "leaky" mutation is classified as ________. A) null/ amorphic B)hypomorphic C) hypermorphic D) neomorphic E) dominant negative

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Genetics: Analysis and Principles

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