Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 16.5, Problem 2COMQ
Summary Introduction
Introduction:
The epigenetic changes that cause cancer cells to form are due to the modifications that occur in the cells. The modifications include; histone modifications, methylation of DNA (deoxyribonucleic acid) and remodeling of chromatids. The abnormalities caused due to the modifications turn into cancer cells.
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Which of the following mutations is MOST likely to cause cancer?
A) a mutation that causes a cyclin gene to be expressed at all times during the cell cycle
B) a mutation that causes an oncogene to be turned off so that no protein is made
C) a mutation that causes a Cdk gene to be turned off so that no protein is made
D) a mutation that causes a tumor suppressor gene to be over-expressed
Normal (nonmutant) tumor-suppressor genes often functiona. as negative regulators of cell division.b. in the maintenance of genome integrity.c. in the stimulation of cell division.d. as both a and b.
Which of the following effectively describes the situation of someone with an inherited predisposition to cancer such as familial adenomatous polyposis or BRCA-associated familial breast cancer?
Choose all that apply
a) If they get malignant cancer, somatic mutations will not have been a factor
b) Their cancer will most likely arise in their germ cells, not their somatic cells
c) None of the answers effectively describes the situation
d) Every cell of their body contains a gain-of-function allele of an oncogene
e) Most cells in their body contain multiple cancer-causing mutations
f) Every cell of their body contains a defective, loss-of-function allele of a tumor suppressor gene
Chapter 16 Solutions
Genetics: Analysis and Principles
Ch. 16.1 - Which of the following are examples of molecular...Ch. 16.1 - 2. An epigenetic modification to a specific gene...Ch. 16.1 - Prob. 3COMQCh. 16.1 - Epigenetic changes may a. be programmed during...Ch. 16.2 - 1. For the Igf2 gene, where do de novo methylation...Ch. 16.2 - 2. For XCI to occur, where are the Xist and Tsix...Ch. 16.2 - 3. Which of the following possibilities could...Ch. 16.3 - 1. Which of the following statements about...Ch. 16.3 - The effects of paramutation may vary with regard...Ch. 16.4 - 1. When mice carrying theallele exhibit a darker...
Ch. 16.4 - 2. If the VIN3 gene had a loss-of-function...Ch. 16.5 - Prob. 1COMQCh. 16.5 - Prob. 2COMQCh. 16 - Prob. 1CONQCh. 16 - List and briefly describe five types of molecular...Ch. 16 - Prob. 3CONQCh. 16 - What is the key difference between cis and...Ch. 16 - Prob. 5CONQCh. 16 - Prob. 6CONQCh. 16 - 7. Outline the molecular steps in the process of...Ch. 16 - Prob. 8CONQCh. 16 - 9. In general, explain how epigenetic...Ch. 16 - 10. What are the contrasting roles of trithorax...Ch. 16 - Describe the molecular steps by which polycomb...Ch. 16 - Prob. 12CONQCh. 16 - Using coat color in mice and the development of...Ch. 16 - How can environmental agents that do not cause...Ch. 16 - Prob. 15CONQCh. 16 - Prob. 16CONQCh. 16 - Explain how the VIN3/PRC2 complex specifically...Ch. 16 - Prob. 1EQCh. 16 - In the experiments described in Figure 16.8,...Ch. 16 - Prob. 3EQCh. 16 - A research study indicated that an agent in...Ch. 16 - Lets suppose you were interested in developing...Ch. 16 - Prob. 6EQCh. 16 - Prob. 7EQCh. 16 - 2. Discuss the similarities and differences of...
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- Which of the following accurately compares tumor suppressor genes and proto-oncogenes? A. Both tumor suppressor and proto-oncogenes prevent the spread of cancer by targeting and destroying existing cancer cells. B. A person who has both tumor suppressor and proto-oncogenes will always develop cancer. C. Proto-oncogenes code for growth factors, while tumor suppressor genes inhibit cell division of damaged cells. D. When a proto-oncogene mutates, it becomes a tumor suppressor gene.arrow_forwardDiscuss the interplay between genetics and environment in the development of cancer (it would be helpful to focus on one tumor suppressor/disease to narrow the scope of the discussion). Which factor (genetics or environment) is playing a larger role within your chosen context? Justify your argument.arrow_forwardWhy is it easier to manipulate embryonic stem cells to differentiate into various tissues than it is to manipulate a typical adult cell? a. As cells develop, signaling pathways can cause some genes to be turned off during development. b. Adult cells have different DNA content than do embryonic stem cells. c. Emybronic stem cells pose less of a threat for organ rejection as do an individual s own adult cells. d. It is no easier to manipulate emybronic stem cells to differentiate into various tissues than it is to manipulate a typical adult cell.arrow_forward
- Which of the following statements correctly describes a characteristic of tumor-suppressor gene? a) they are frequently overexpressed in cancerous cells. b) they are cancer-causing genes introduced into cells by viruses. c) they encode proteins that help prevent uncontrolled cell growth. d) they often encode proteins that stimulate the cell cycle.arrow_forwardWith regard to cancer cells, which of the following statementsare true?A. Cancer cells are clonal, which means they are derived from asingle mutant cell.B. To become cancerous, cells usually accumulate multiplegenetic changes that eventually result in uncontrolledgrowth.C. Most cancers are caused by oncogenic viruses.D. Cancer cells have lost the ability to properly regulate celldivision.arrow_forwardCharacterize the differences between tumor cells and normal cells in terms of the following properties. In cancer cells, how might each of these properties contribute to tumor progression? a) contact inhibition b) autocrine stimulation c) apoptosis d) senescence due to telomere shortening e) genomic stability f) angiogenises g) metastasisarrow_forward
- Describe two mechanisms by which genetic change causes cancer.arrow_forwardWhich of the following statements about cancer is false? (a) oncogenes arise from mutations in proto-oncogenes (b) tumor suppressor genes normally interact with growth-inhibiting factors to block cell division (c) more than 120 cancer-driving genes have been discovered (d) oncogenes were first discovered in mouse models for cancer (e) the development of cancer is usually a multistep process involving both oncogenes and mutated tumor suppressor genesarrow_forwardDescribe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?arrow_forward
- Explain the molecular mechanisms of cancers caused by a P53 gene mutation.arrow_forwardWhich of the following must scientists understand in order to create effective cancer treatments? Select all that apply. a why cancer is difficult to treat b where cancer originated c how cancer cells multiply d how cancer cells growarrow_forwardThe p53 gene was discovered in 1979, but it was not clear whether the gene functioned as an oncogene or a tumor-suppressor gene. Several years later, researchers showed that both p53 alleles are inactivated in some mouse cancers. This evidence suggests A. the p53 gene is an oncogene because inactivated alleles would produce mutated signal transduction proteins that would result in stimulating cell division. B. the p53 gene is an oncogene because the cell would overproduce transcription factors to compensate for the inactive alleles, resulting in increased cell division. C. the p53 gene is a tumor-suppressor gene because inactivated alleles indicate a loss of protein function which allowed the cancer to develop D. the p53 gene is a tumor-suppressor gene because the cell would produce too few transcription factors for gene activation, resulting in decreased cell division.arrow_forward
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