Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 16, Problem 6CONQ
Summary Introduction
To review:
The effect of the mutation on the expression of Igf2 gene, if the mutation is inherited from the mother and removes the ICR (imprinting control region) next to the Igf2 gene.
Introduction:
The Igf2 is the gene, which is present in mammals, which exhibits epigenetic inheritance. The methylation of DNA (deoxyribonucleic acid)occurs at a specific site called the ICR, which is located between the Igf2 gene and the H19 gene. There is the formation of the loop, which helps in the process of epigenetics and changes the gene expression.
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Let’s suppose a mutation removes the ICR next to the Igf2 gene. Ifthis mutation is inherited from the mother, will the Igf2 gene (fromthe mother) be silenced or expressed? Explain.
A geneticist uses a generic engineering approach to mutate the TATA-building protein (TBP) of a murine cell line that ordinarily produces high amounts of the LNS protein. The mutation prevents the binging of the TBP to the TATA box. What would be the effect on the cell line that possesses the mutation, especially LNS protein levels?
A translocation mutation results in a silencer being inserted just upstream of the promoter of a gene (Gene X). How would you predict the expression of gene X be affected by this mutation?
Gene X will not be expressed in any cell that has this mutation
Gene X will not be expressed in any cell that has this mutation and the appropriate repressor protein
Gene X will be expressed in any cell that has this mutation
Gene X will be expressed in any cell that has this mutation and the appropriate repressor protein
Chapter 16 Solutions
Genetics: Analysis and Principles
Ch. 16.1 - Which of the following are examples of molecular...Ch. 16.1 - 2. An epigenetic modification to a specific gene...Ch. 16.1 - Prob. 3COMQCh. 16.1 - Epigenetic changes may a. be programmed during...Ch. 16.2 - 1. For the Igf2 gene, where do de novo methylation...Ch. 16.2 - 2. For XCI to occur, where are the Xist and Tsix...Ch. 16.2 - 3. Which of the following possibilities could...Ch. 16.3 - 1. Which of the following statements about...Ch. 16.3 - The effects of paramutation may vary with regard...Ch. 16.4 - 1. When mice carrying theallele exhibit a darker...
Ch. 16.4 - 2. If the VIN3 gene had a loss-of-function...Ch. 16.5 - Prob. 1COMQCh. 16.5 - Prob. 2COMQCh. 16 - Prob. 1CONQCh. 16 - List and briefly describe five types of molecular...Ch. 16 - Prob. 3CONQCh. 16 - What is the key difference between cis and...Ch. 16 - Prob. 5CONQCh. 16 - Prob. 6CONQCh. 16 - 7. Outline the molecular steps in the process of...Ch. 16 - Prob. 8CONQCh. 16 - 9. In general, explain how epigenetic...Ch. 16 - 10. What are the contrasting roles of trithorax...Ch. 16 - Describe the molecular steps by which polycomb...Ch. 16 - Prob. 12CONQCh. 16 - Using coat color in mice and the development of...Ch. 16 - How can environmental agents that do not cause...Ch. 16 - Prob. 15CONQCh. 16 - Prob. 16CONQCh. 16 - Explain how the VIN3/PRC2 complex specifically...Ch. 16 - Prob. 1EQCh. 16 - In the experiments described in Figure 16.8,...Ch. 16 - Prob. 3EQCh. 16 - A research study indicated that an agent in...Ch. 16 - Lets suppose you were interested in developing...Ch. 16 - Prob. 6EQCh. 16 - Prob. 7EQCh. 16 - 2. Discuss the similarities and differences of...
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- What is the key difference between cis- and trans-epigenetic mechanisms for maintaining an epigenetic modification? We considered genomic imprinting of the Igf2 gene, in whichoffspring express the copy of the gene they inherit from their father,but not the copy they inherit from their mother. Is this a cisora trans-epigenetic mechanism?arrow_forwardAt which level of gene regulation shown in Figure 16.1 does attenuation occur?arrow_forwardGive and briefly explain two examples of how gene expression may be repressed without altering the gene-coding sequence.arrow_forward
- Give two examples of how gene expression may be repressed without altering the coding sequence.arrow_forwarda hormone receptor gene is deleted from the genome of a cell.in the absence of the hormone,what would you except about the expression of a gene that is activated by the hormone signiling?what would you expect to happen to the gene expression if the same cell is now treated with hormone?arrow_forwardWhat is the effect of an increased Cro concentration on the expression of the gene for the λ repressor? Of an increased concentration of λ repressor on the expression of the Cro gene? Of an increased concentration of λ repressor on the expression of the λ repressor gene?arrow_forward
- What is a second messenger? What are two second messengers that are involved in signaling pathways downstream of GPCRs and explain how they are produced? long answer: If you wanted to compare a cardiac muscle cell with a skeletal muscle, how could you use RNA sequencing to identify genes that are differentially expressed? In your answer, explain this technique and describe what type of information you can learn from it. If RNA sequencing led to the identification of two genes, gene X and gene Y, what are two experiments you could do to study the functions of these two genes?arrow_forwardAs shown in Figure 13-22, how many different transcription factors govern where the Distal-less (Dll) gene willbe expressed?arrow_forwardFor the Igf2 gene, where do de novo methylation and maintenancemethylation occur?a. De novo methylation occurs in sperm, and maintenancemethylation occurs in egg cells.b. De novo methylation occurs in egg cells, and maintenancemethylation occurs in sperm cells.c. De novo methylation occurs in sperm, and maintenancemethylation occurs in somatic cells of offspring.d. De novo methylation occurs in egg cells, and maintenancemethylation occurs in somatic cells of offspring.arrow_forward
- If p63 can bind to the same promoter elements as p53, why would it be considered an inhibitor of p53? Can you clarify this relationship a bit?arrow_forwardGiven the following schematic for a gene and its associated regulatory regions, answer the following questions by placing the correct letter in the provided blanks please put in the correct letter for the questions What region would provide cell type-specific expression of genes? region What site would significantly increase gene expression rates? = region What region or regions of this gene’s coding sequence are expressed as amino acids = regionarrow_forwardA gene, which we will call gene C, can be epigenetically modified in such a way that its expression in some cells is permanently silenced. Describe how you could conduct cell-fusion experiments to determine if a cis- or a trans-epigenetic mechanism is responsible for maintaining the silencing of gene C.arrow_forward
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