Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 18, Problem 12RQ
Summary Introduction
To review:
Definition of the following terminologies:
a. Gene silencing
b. RNA (ribonucleic acid) interference
c. Tumor suppressor gene
d. Proto-oncogene
e. GEF (guanine
Introduction:
In several diseased conditions, it becomes important to control or repress the gene expression of a particular gene. For example, in cancerous cells, it is important to inhibit or repress the expression of various tumor promoter genes. There are some techniques for the purpose, such as, gene silencing and RNA interference.
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QUESTION 22
The DNA sequences that are most conserved between human and mouse would most likely be located in:
A
Highly-repeated sequences, such as microsatellite regions
B
Highly repeated sequences, such as Alu sequences
C
Moderately-repeated non-coding sequences
D
Coding regions of single-copy genes
QUESTION NO. 1 Fragile X syndrome is a common form of inherited mental retardation. The mutation in the disease allows the increase of a CGG repeat in a particular gene from a normal of about 30 repeats to 200-1000 repeats. This repeat is normally found in the 5' untranslated region of a gene for the protein FMR1. FMR1 might be involved in the translation of brain-specific mRNAs during brain development. The consequence of the very large number of CGG repeats in the DNA is extensive methylation of the entire promoter region of the FMR1 gene. Methylation of bases in DNA usually
A. facilitates the binding of transcription factors to the DNA.
B. makes a difference in activity only if it occurs in an enhancer region.
C. prevents chromatin from unwinding.
D. inactivates DNA for transcription.
E. results in increased production of the produce of whatever gene is methylated.QUESTION NO. 2
The best definition of an endonuclease is that it hydrolyzes
A. nucleotide from…
QUESTION 18
tRNA exits the ribosome at the _______________ site.
E
P
A
Chapter 18 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 18 - Prob. 1QCh. 18 - Prob. 2QCh. 18 - Prob. 3QCh. 18 - Prob. 4QCh. 18 - Prob. 5QCh. 18 - Prob. 1RQCh. 18 - Prob. 2RQCh. 18 - Prob. 3RQCh. 18 - Prob. 4RQCh. 18 - Prob. 5RQ
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