Chapter 18, Problem 67TQ

Summary Introduction

To review:

The way in which phorbol ester induces transcription of AP-1-influenced genes, its consequences, and the role it plays in the intermittent exposure to phorbol esters on the health of an individual.

Introduction:

There are several tumor promoters in nature, such as asbestos, components of tobacco smoke, and phorbol esters. Phorbol esters are obtained from croton oil, which is extracted from the seeds of Croton tiglum. Phorbol esters are able to mimic DAG (diacylglycerol) action.