The conversion of benzoic acid to benzylamine by using reductive amination is to be shown. Concept introduction: Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine. Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

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Answer 1

Question

Chapter 19, Problem 19.47SP

(a)

Interpretation Introduction

Interpretation:

The conversion of benzoic acid to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(b)

Interpretation Introduction

Interpretation:

The conversion of benzaldehyde to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(c)

Interpretation Introduction

Interpretation:

The conversion of pyrrolidine to N-ethylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(d)

Interpretation Introduction

Interpretation:

The conversion of cyclohexanone to N-cyclohexylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(e)

Interpretation Introduction

Interpretation:

The conversion of pentan 1,5-dioic acid to pentan 1,5-diamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

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The two most general amine syntheses are the reductive amination of carbonyl compounds and the reduction of amides.Show how these techniques can be used to accomplish the following syntheses.(a) benzoic acid S benzylamine (b) benzaldehyde S benzylamine(c) pyrrolidine S N@ethylpyrrolidine (d) cyclohexanone S N@cyclohexylpyrrolidine(e) HOOC¬(CH2)3 ¬COOH S pentane@1,5@diamine (cadaverine)

Several additional amine syntheses are effectively limited to making primary amines. The reduction of azides and nitrocompounds and the Gabriel synthesis leave the carbon chain unchanged. Formation and reduction of a nitrile adds onecarbon atom. Show how these amine syntheses can be used for the following conversions.(a) allyl bromide S allylamine (b) ethylbenzene S p@ethylaniline

Several additional amine syntheses are effectively limited to making primary amines. The reduction of azides and nitrocompounds and the Gabriel synthesis leave the carbon chain unchanged. Formation and reduction of a nitrile adds onecarbon atom. Show how these amine syntheses can be used for the following conversions. (c) 1@bromo@3@phenylheptane S 3@phenylheptan@1@amine (d) 1@bromo@3@phenylheptane S 4@phenyloctan@1@amine

Answer 2

Question

Chapter 19, Problem 19.47SP

(a)

Interpretation Introduction

Interpretation:

The conversion of benzoic acid to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(b)

Interpretation Introduction

Interpretation:

The conversion of benzaldehyde to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(c)

Interpretation Introduction

Interpretation:

The conversion of pyrrolidine to N-ethylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(d)

Interpretation Introduction

Interpretation:

The conversion of cyclohexanone to N-cyclohexylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(e)

Interpretation Introduction

Interpretation:

The conversion of pentan 1,5-dioic acid to pentan 1,5-diamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

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Answer 3

Question

Chapter 19, Problem 19.47SP

(a)

Interpretation Introduction

Interpretation:

The conversion of benzoic acid to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(b)

Interpretation Introduction

Interpretation:

The conversion of benzaldehyde to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(c)

Interpretation Introduction

Interpretation:

The conversion of pyrrolidine to N-ethylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(d)

Interpretation Introduction

Interpretation:

The conversion of cyclohexanone to N-cyclohexylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(e)

Interpretation Introduction

Interpretation:

The conversion of pentan 1,5-dioic acid to pentan 1,5-diamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

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Answer 4

Question

Chapter 19, Problem 19.47SP

(a)

Interpretation Introduction

Interpretation:

The conversion of benzoic acid to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(b)

Interpretation Introduction

Interpretation:

The conversion of benzaldehyde to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(c)

Interpretation Introduction

Interpretation:

The conversion of pyrrolidine to N-ethylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(d)

Interpretation Introduction

Interpretation:

The conversion of cyclohexanone to N-cyclohexylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(e)

Interpretation Introduction

Interpretation:

The conversion of pentan 1,5-dioic acid to pentan 1,5-diamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

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Answer 5

Chapter 19, Problem 19.47SP

(a)

Interpretation Introduction

Interpretation:

The conversion of benzoic acid to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(b)

Interpretation Introduction

Interpretation:

The conversion of benzaldehyde to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(c)

Interpretation Introduction

Interpretation:

The conversion of pyrrolidine to N-ethylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(d)

Interpretation Introduction

Interpretation:

The conversion of cyclohexanone to N-cyclohexylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

(e)

Interpretation Introduction

Interpretation:

The conversion of pentan 1,5-dioic acid to pentan 1,5-diamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

Answer 6

Chapter 19, Problem 19.47SP

(a)

Interpretation Introduction

Interpretation:

The conversion of benzoic acid to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

Answer 7

Chapter 19, Problem 19.47SP

(a)

Interpretation Introduction

Interpretation:

The conversion of benzoic acid to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

Answer 8

(b)

Interpretation Introduction

Interpretation:

The conversion of benzaldehyde to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

Answer 9

(b)

Interpretation Introduction

Interpretation:

The conversion of benzaldehyde to benzylamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

Answer 10

(c)

Interpretation Introduction

Interpretation:

The conversion of pyrrolidine to N-ethylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

Answer 11

(c)

Interpretation Introduction

Interpretation:

The conversion of pyrrolidine to N-ethylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

Answer 12

(d)

Interpretation Introduction

Interpretation:

The conversion of cyclohexanone to N-cyclohexylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

Answer 13

(d)

Interpretation Introduction

Interpretation:

The conversion of cyclohexanone to N-cyclohexylpyrrolidine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

Answer 14

(e)

Interpretation Introduction

Interpretation:

The conversion of pentan 1,5-dioic acid to pentan 1,5-diamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

Answer 15

(e)

Interpretation Introduction

Interpretation:

The conversion of pentan 1,5-dioic acid to pentan 1,5-diamine by using reductive amination is to be shown.

Concept introduction:

Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine.

Reduction of amide is a process in which amide group is reduced to amines in the presence of reducing agents. Lithium aluminium hydride is a good reducing agent for such processes.

Answer 16

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Answer 17

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Answer 18

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Answer 19

Ch. 19.2A - Prob. 19.1P Ch. 19.2B - Prob. 19.2P Ch. 19.2B - Give correct names for the following amines:Ch. 19.3 - Prob. 19.4P Ch. 19.4 - Prob. 19.5P Ch. 19.6 - Rank each set of compounds in order of increasing...Ch. 19.8A - Prob. 19.7P Ch. 19.8C - Prob. 19.8P Ch. 19.8C - Prob. 19.9P Ch. 19.8D - a. Show how fragmentation occurs to give the base...

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