(a)
Interpretation:
The synthesis of given tertiary
Concept introduction:
Reductive amination is also known as reductive alkylation. This is basically used for the conversion of a carbonyl group to an amine via an intermediate imine. The carbonyl groups generally are
(b)
Interpretation:
The synthesis of given tertiary amine in three different ways by using acylation-reduction is to be shown.
Concept introduction:
Acylation-reduction is a process in which compound first undergoes acylation process. One of the best acylation processes is Friedel Craft acylation. Then the compound undergoes reduction process by suitable reducing agent or by catalytic reduction in the presence of metals like
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- Several additional amine syntheses are effectively limited to making primary amines. The reduction of azides and nitrocompounds and the Gabriel synthesis leave the carbon chain unchanged. Formation and reduction of a nitrile adds onecarbon atom. Show how these amine syntheses can be used for the following conversions.(a) allyl bromide S allylamine (b) ethylbenzene S p@ethylanilinearrow_forward4. what is the mechanism for this reductive amination reaction?arrow_forwardExcess ammonia must be used when a primary amine is synthesized by reductive amination. What product will be obtained if the reaction is carried out with excess carbonyl compound?arrow_forward
- Draw a detailed mechanism for the reactions performed in this experiment, starting from p-vanillin and benzylamine and ending with the amine product (reductive amination of p-vanillin and benzylamine, resulting in the formation of 4-((benzylamino)methyl)-2-methoxyphenol.). plz answer in details. thanksarrow_forwardWhat kinds of halides cannot be used to alkylate an amine? Why not? a.Tertiary halides form alkenes on elimination. b.Aryl halides unless activated by electron-withdrawing groups c.Halides with beta-alkyl groups are sterically hindered. d. all of the abovearrow_forwardWhat product(s) would you expect from the Hofmann elimination of the following amines? If more than one products are formed, identify, with reasons the major product. PLEASE SHOW ALL THE PRODUCTS IF MORE THAN ONE AND ALSO SPECIFY THE MAJOR PRODUCT FOR BOTH THE A PART AND B PART (Part a and b in the picture attached)arrow_forward
- Give a reaction you could use to convertbenzamide to anilinearrow_forwardHow different would step 4 be if the amine was secondary? Show curved arrows and explain the mechanism!arrow_forwardwhy is the formation of an amide from an acid chloride proceeds easily when appropriate amount of amine is added to the reaction but an amide to an acid chloride is impossiblearrow_forward
- Write the mechanism for the reaction between a secondary amine and excess alkyl halide to form the product shown. show each step.arrow_forwardSynthesis of p-Bromoaniline Why is the protection of the amine function needed in this reaction? a) The protection increases the selectivity for the ortho substitution. b) The protection increases the reactivity of the reactant in the bromination. c) The protection changes the regioselectivity of reaxtion.arrow_forwardWhen the (R,R) isomer of the amine shown is treated with an excess of methyl iodide, then silver oxide, then heated, the majorproduct is the Hofmann product.) Some Zaitsev product is also formed. It has the (E) configuration. When the same amine is treated with mCPBA and heated, theZaitsev product has the (Z) configuration. Use stereochemical drawings of the transition states to explain these observationsarrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning