Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 4, Problem 5RQ
Summary Introduction

Introduction:

Thermodynamics is the investigation of energy transformations that accompany physical and chemical changes in matter. Those energy transformations thatoccur inside the living organism are studied under bioenergetics. The thermodynamic properties include enthalpy, work, entrop, ynd free energy. Some of these properties are state functions thatonly depend upon the initial and final states, and not upon the whole path involved.

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Question 4. Diabetes mellitus possesses a serious health challenge worldwide and there has been an increased awareness for self-monitoring and point of care testing. The development of self- monitoring of blood glucose (SMBG) is probably the most important advance in controlling diabetes since the discovery of insulin. a) Dextrostix, the first glucose meter was invented by Ernie Adams. Briefly discuss. b) There are three principles of enzymatic reactions, utilized by current glucose meters. Compare and briefly discuss these three principles.
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Question 1. Enzymes, proteins and deoxyribonucleic acid (DNA) are important biological macromolecules. Enzymes are not only speed up the reaction, but also are necessary for DNA reproduction. e) Michaelis - Menten Kinetics model explains how reaction rates are depending on the concentration of enzyme and substrate. i. What is meant by the saturation of enzyme? ii. A decrement in enzyme activity is known as enzyme inhibition. Based on normal enzyme activity, explain the enzyme kinetics for competitive inhibition and noncompetitive inhibition, as shown in Figure 1. Normal enzyme Competitive inhibitor Noncompetitive inhibitor Substrate concentration Figure 1: Enzyme inhibition f) What is the importance of cofactor in the enzyme activity? Give an example of a disease that is related with cofactors. Rate of reaction
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