The article "Celulose Acetate Microspheres Prepared by O/W Emulsification and Solvent Evaporation Method" (K. Soppinmath, A. Kulkami, et al., Journal of Microencapsulation, 2001:811-817) describes a study of the effects of the concentrations of polyvinyl alcohol (PVAL) and dichloromethane (DCM) on the encapsulation efficiency in a process that produces microspheres containing the drug ibuprofen. There were three concentrations of PVAL (measured in units of % wiv) and three of DCM (in mL). The results presented in the following table are consistent with the means and standard deviations presented in the article. PVAL DCM = 50 DCM = 40 DCM = 30 0.5 98.983 99.268 95.149 96.810 94.572 86.718 75.288 74.949 72.363 1.0 89.827 94.136 96.537 82.352 79.156 80.891 76.625 76.941 72.635 2.0 95.095 95.153 92.353 86.153 91.653 87.994 80.059 79.200 77.141 Construct an ANOVA table. You may give ranges for the P-values. b. Discuss the relationships among PVAL concentration, DCM concentration, and encapsulation efficiency. a.

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The article "Celulose Acetate Microspheres Prepared by O/W Emulsification and Solvent
Evaporation Method" (K. Soppinmath, A. Kulkami, et al., Journal of Microencapsulation,
2001:811-817) describes a study of the effects of the concentrations of polyvinyl alcohol
(PVAL) and dichloromethane (DCM) on the encapsulation efficiency in a process that
produces microspheres containing the drug ibuprofen. There were three concentrations of
PVAL (measured in units of % wiv) and three of DCM (in mL). The results presented in the
following table are consistent with the means and standard deviations presented in the
article.
PVAL
DCM = 50
DCM = 40
DCM = 30
0.5
98.983 99.268 95.149 96.810 94.572 86.718 75.288 74.949 72.363
1.0
89.827 94.136 96.537 82.352 79.156 80.891 76.625 76.941 72.635
2.0
95.095 95.153 92.353 86.153 91.653 87.994 80.059 79.200 77.141
Construct an ANOVA table. You may give ranges for the P-values.
b. Discuss the relationships among PVAL concentration, DCM concentration, and
encapsulation efficiency.
a.
Transcribed Image Text:The article "Celulose Acetate Microspheres Prepared by O/W Emulsification and Solvent Evaporation Method" (K. Soppinmath, A. Kulkami, et al., Journal of Microencapsulation, 2001:811-817) describes a study of the effects of the concentrations of polyvinyl alcohol (PVAL) and dichloromethane (DCM) on the encapsulation efficiency in a process that produces microspheres containing the drug ibuprofen. There were three concentrations of PVAL (measured in units of % wiv) and three of DCM (in mL). The results presented in the following table are consistent with the means and standard deviations presented in the article. PVAL DCM = 50 DCM = 40 DCM = 30 0.5 98.983 99.268 95.149 96.810 94.572 86.718 75.288 74.949 72.363 1.0 89.827 94.136 96.537 82.352 79.156 80.891 76.625 76.941 72.635 2.0 95.095 95.153 92.353 86.153 91.653 87.994 80.059 79.200 77.141 Construct an ANOVA table. You may give ranges for the P-values. b. Discuss the relationships among PVAL concentration, DCM concentration, and encapsulation efficiency. a.
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