Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Question
Chapter 10, Problem 61TQ
Summary Introduction
To review:
The inhibition of oxidative phosphorylation by rotenone that can take place when the substrate is pyruvate but not when succinate is used.
Introduction:
The oxidative phosphorylation is the mechanism by which the conservation of the adenosine triphosphate (ATP) generated by the electron transport chain (ETC) takes place due to the phosphorylation of adenosine diphosphate (ADP). There are many inhibitors of the ETC like antimycin A, rotenone, amyta, lnd azide. They can be used to determine the correct order of the ETC.
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Chapter 10 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 10 - Prob. 1QCh. 10 - Prob. 2QCh. 10 - Prob. 3QCh. 10 - Prob. 4QCh. 10 - Prob. 5QCh. 10 - Prob. 6QCh. 10 - Prob. 7QCh. 10 - Prob. 8QCh. 10 - Prob. 1RQCh. 10 - Prob. 2RQ
Ch. 10 - Prob. 3RQCh. 10 - Prob. 4RQCh. 10 - Prob. 5RQCh. 10 - Prob. 6RQCh. 10 - Prob. 7RQCh. 10 - Prob. 8RQCh. 10 - Prob. 9RQCh. 10 - Prob. 10RQCh. 10 - Prob. 11RQCh. 10 - Prob. 12RQCh. 10 - Prob. 13RQCh. 10 - Prob. 14RQCh. 10 - Prob. 15RQCh. 10 - Prob. 16RQCh. 10 - Prob. 17RQCh. 10 - Prob. 18RQCh. 10 - Prob. 19RQCh. 10 - Prob. 20RQCh. 10 - Prob. 21RQCh. 10 - Prob. 22RQCh. 10 - Prob. 23RQCh. 10 - Prob. 24RQCh. 10 - Prob. 25RQCh. 10 - Prob. 26RQCh. 10 - Prob. 27RQCh. 10 - Prob. 28RQCh. 10 - Prob. 29RQCh. 10 - Prob. 30RQCh. 10 - Prob. 31RQCh. 10 - Prob. 32RQCh. 10 - Prob. 33RQCh. 10 - Prob. 34RQCh. 10 - Prob. 35FBCh. 10 - Prob. 36FBCh. 10 - Prob. 37FBCh. 10 - Prob. 38FBCh. 10 - Prob. 39FBCh. 10 - Prob. 40FBCh. 10 - Prob. 41FBCh. 10 - Prob. 42FBCh. 10 - Prob. 43FBCh. 10 - Prob. 44FBCh. 10 - Prob. 45SACh. 10 - Prob. 46SACh. 10 - Prob. 47SACh. 10 - Prob. 48SACh. 10 - Prob. 49SACh. 10 - Prob. 50TQCh. 10 - Prob. 51TQCh. 10 - Prob. 52TQCh. 10 - Prob. 53TQCh. 10 - Prob. 54TQCh. 10 - Prob. 55TQCh. 10 - Prob. 56TQCh. 10 - Prob. 57TQCh. 10 - Prob. 60TQCh. 10 - Prob. 61TQCh. 10 - Prob. 62TQCh. 10 - Prob. 63TQCh. 10 - Prob. 64TQCh. 10 - Prob. 65TQCh. 10 - Prob. 66TQ
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- Question 1: The overall process enabled by the glyoxylate cycle is: (2acetyl-CoA) + (NAD+) + (2H2O) → (succinate) + (2CoA) + (NADH) + (2H+) Dissect this process further by writing down all of the reactions that are actually involved in making one succinate from two acetyl-CoA units. Show chemical structure for all intermediates.arrow_forwardWhat citric acid cycle intermediates would accumulate in the presence of malonate?arrow_forwardWhat is ornithine transcarbamylase (OTC)deficiency ?arrow_forward
- How is it possible for fluoroacetate to enter the citric acid cycle?arrow_forwardWhat is the enzyme classification of the catalyst used in the conversion ofdihydroxyacetone phosphate to glyceraldehyde-3-phosphatearrow_forwardAll coenzymes are cofactors, but not all cofactors are coenzymes. Explain this statement.arrow_forward
- Why is oxaloacetate an intermediate in gluconeogenesis?arrow_forwardThe citric acid cycle itself, which is composed of enzymatically catalyzed steps, can be thought of essentially as a supramolecular enzyme. Explain.arrow_forwardWhat is a diauxic shift, a term that is used in referenceto microorganisms in cell culture? Where does it occurin glucose metabolism?arrow_forward
- What is the simplest explanation in the notion that phosphofructokinase is a regulated enzyme?arrow_forwardWhat two major kinds of chemical reactions occur in the citric acid cycle, and how are these reactions indicated symbolically?arrow_forwardHow does pyruvate carboxylase deficiency result in lactic aciduria, an illness in which lactate appears in the urine?arrow_forward
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