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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 11, Problem 15QP
Textbook Problem
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Trinucleotide repeats cause serious neurodegenerative disorders such as Huntington disease, fragile-X syndrome, and myotonic dystrophy (DM). The process of anticipation causes the appearance of symptoms at earlier ages in succeeding generations. Describe the current theory of the way anticipation works.

Summary Introduction

To explain: The working principle of the anticipation theory.

Introduction: Trinucleotide repeats are the sequences of three nucleotides which appear several times in the consecutive order in the gene. It converts a normal gene into a mutant gene. It was first discovered in X-chromosome of the fragile-X syndrome. It is a type of intellectual disability.

Explanation of Solution

Anticipation theory explains the cause that why symptoms of genetic disorders appear at an early age when the disease passes from one generation to another. This theory typically works in the case of disorders related to trinucleotide repeats. When the diseased gene (gene with trinucleotide repeats) passes from one generation to another, the number of repeats can change. They can increase on passing from parent to child...

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