Essentials Of Genetics (9th Global Edition)
9th Edition
ISBN: 9780134143637
Author: William S. Klug, Michael R. Cummings
Publisher: Pearson Global Edition
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Chapter 17, Problem 21PDQ
One complication of making a transgenic animal is that the transgene may integrate at random into the coding region, or the regulatory region, of an endogenous gene. What might be the consequences of such random integrations? How might this complicate genetic analysis of the transgene?
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One complication of making a transgenic animal is that thetransgene might integrate at random into the coding region, orthe regulatory region, of an endogenous gene. What might be theconsequences of such random integrations? How might this complicategenetic analysis of the transgene?
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Chapter 17 Solutions
Essentials Of Genetics (9th Global Edition)
Ch. 17 -
CASE STUDY |Should we worry about recombinant DNA...Ch. 17 - Prob. 2CSCh. 17 - Prob. 3CSCh. 17 -
HOW DO WE KNOW?
1. In this chapter we focused on...Ch. 17 - Prob. 2PDQCh. 17 - What roles do restriction enzymes, vectors, and...Ch. 17 - Prob. 4PDQCh. 17 - Prob. 5PDQCh. 17 - Prob. 6PDQCh. 17 - Prob. 7PDQ
Ch. 17 - List the advantages and disadvantages of using...Ch. 17 - What are the advantages of using a restriction...Ch. 17 - The introduction of genes into plants is a common...Ch. 17 - Prob. 11PDQCh. 17 - Prob. 12PDQCh. 17 - Prob. 13PDQCh. 17 - What advantages do cDNA libraries provide over...Ch. 17 - Prob. 15PDQCh. 17 -
16. List the steps involved in screening a...Ch. 17 -
17. In a typical PCR reaction, describe what is...Ch. 17 -
18. We usually think of enzymes as being most...Ch. 17 - How are dideoxynucleotides (ddNTPs) structurally...Ch. 17 - Prob. 20PDQCh. 17 - One complication of making a transgenic animal is...Ch. 17 -
22. When disrupting a mouse gene by knockout, why...Ch. 17 - Prob. 23PDQ
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- in the cloning vector, what would be the plausible impacts if a mutation at the Ori site renders it non- functional?arrow_forwardWhat is the difference between manipulating a gene for gene therapy and for producing a transgenic organism?arrow_forwardList the three features of a cloning vector and why these elements are neededarrow_forward
- What is meant by a transgenic animal?arrow_forwardWhy do gene targeting and mutagenesis screening in mice have potential benefits for humans?arrow_forward. In selecting target cells to receive a transferred gene in gene therapy in an adult person, what factors do you think would have to be taken into account for a successful treatment?arrow_forward
- Gene expression can be disrupted by techniques such as homologous recombination and RNA interference. What is the functional difference between these two methods in terms of the ultimate effect on gene expression? Why might homologous recombination or an alternative genome-editing method (e.g., CRISPR/Cas9) be preferred over RNA interference?arrow_forwardWhat is using somatic nuclei of transgenic adults to generate other animals with identical genomes?arrow_forwardHow to incorporate prokaryotic gene into eukaryotic cell to make an transgenic organism?In this case what promoter will be used.explain the process in detailsarrow_forward
- Early gene-cloning experiments involved insertion at one restriction site in the vector; for example, the insert would have an EcoRI site at each end, and the vector would be opened at an EcoRI site prior to ligation. Under what circumstances would asymmetric cloning be desirable, with the insert having a different restriction site at each endarrow_forwardWhat is difference between transgenic animals and transgenic plant?arrow_forwardWhat are selectable markers and why are they important to cloning vectors?arrow_forward
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