Genetics: Analysis and Principles
Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 24, Problem 15EQ
Summary Introduction

To analyze:

The given sequence of nucleotide from a gene and determine the gene along with the species in which the gene sequence is found.

Introduction:

Genes are made up of deoxyribonucleic acid (DNA). Genes are generally described as the basic, functional, and physical unit of life. Genes do not code for the proteins but they instruct the other molecules to synthesize the proteins. Proteins are the building blocks of the body, made by the polymerization of amino acids.

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Follow these directions to access the entries for PTGS1 and PTGS2 in the “Gene” database at the NCBI Website:A. First, go to the NCBI homepage using the link on the lab webpage, or by going to: http://www.ncbi.nlm.nih.gov Select “Gene” from the database pulldown menu. Type “PTGS” in the search box, then click “Go.” Scan the results for the “Homo sapiens” entries. There should be one called “PTGS1” and one called “PTGS2.” Select each entry by clicking on its name, then read the paragraph under the “Summary” section for each entry. The drug Celebrex selectively inhibits PTGS2 while aspirin and other NSAID’s inhibit both PTGS1 and PTGS2 in the same way. Why do you think researchers wanted to discover a selective inhibitor to PTGS2?      2. Describe how studying 3-D structures of PTGS1 and PTGS2 could help researchers design a drug that binds to PTGS1, but not to PTGS2.
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