Concepts of Genetics (11th Edition)
Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 25, Problem 2PDQ

CONCEPT QUESTION Read the Chapter Concepts list on page 621. All these pertain to the principles of population genetics and the evolution of species. Write a short essay describing the roles of mutation, migration, and selection in bringing about speciation.

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n class we investigated the reason cystic fibrosis is maintained in the human population in higher frequency than we expected given the deleterious effects of being homozygous at the CFTR gene. We calculated the actual mutation rate of the CFTR gene to be 6.7 x 10-7. The mutation rate expected under mutation-selection balance was 4 x 10-4. What is the most plausible explanation as to why cystic fibrosis is maintained in the human population at a higher frequency than we expect?   a. Negative selection against the CFTR deleterious alleles is too weak to eliminate the alleles from the human population.   b. Positive selection for the CFTR deleterious alleles is likely occurring in response to some other selective pressure in the human population, possibly resistance to typhoid fever.   c. The CFTR gene has an exceedingly low mutation rate causing humans to have no genetic variation at that gene.   d. The CFTR gene has an exceedingly high mutation rate and that is…
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Chapter 25 Solutions

Concepts of Genetics (11th Edition)

Ch. 25 - The genetic difference between two Drosophila...Ch. 25 - The use of nucleotide sequence data to measure...Ch. 25 - The ability to taste the compound PTC is...Ch. 25 - Prob. 7PDQCh. 25 - What must be assumed in order to validate the...Ch. 25 - In a population where only the total number of...Ch. 25 - Determine whether the following two sets of data...Ch. 25 - If 4 percent of a population in equilibrium...Ch. 25 - Consider a population in which the frequency of...Ch. 25 - If the initial allele frequencies are p = 0.5 and...Ch. 25 - Under what circumstances might a lethal dominant...Ch. 25 - Assume that a recessive autosomal disorder occurs...Ch. 25 - One of the first Mendelian traits identified in...Ch. 25 - Describe how populations with substantial genetic...Ch. 25 - Achondroplasia is a dominant trait that causes a...Ch. 25 - Prob. 19PDQCh. 25 - Prob. 20PDQCh. 25 - A botanist studying water lilies in an isolated...Ch. 25 - A farmer plants transgenic Bt corn that is...Ch. 25 - In an isolated population of 50 desert bighorn...Ch. 25 - To increase genetic diversity in the bighorn sheep...Ch. 25 - What genetic changes take place during speciation?Ch. 25 - Some critics have warned that the use of gene...Ch. 25 - A form of dwarfism known as Ellisvan Creveld...Ch. 25 - Prob. 28ESPCh. 25 - What are the two groups of reproductive isolating...Ch. 25 - The original source of new alleles, upon which...Ch. 25 - A number of comparisons of nucleotide sequences...Ch. 25 - Shown below are two homologous lengths of the...Ch. 25 - Recent reconstructions of evolutionary history are...Ch. 25 - Prob. 34ESP
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