Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 25, Problem 15PDQ
Assume that a recessive autosomal disorder occurs in 1 of 10,000 individuals (0.0001) in the general population and that in this population about 2 percent (0.02) of the individuals are carriers for the disorder. Estimate the probability of this disorder occurring in the offspring of a marriage between first cousins. Compare this probability to the population at large.
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Students have asked these similar questions
A given autosomal locus has three possible alleles (A1, A2, and A3). Assuming that the numbers of individuals with the six possible genotypes are as follows, what would be the frequency of the A1 allele in the population?
A1A1 = 30 A1A2 = 27 A2A2 = 12
A1A3 = 17 A2A3 = 10 A3A3 = 4
What would be the frequency of the A3A3 genotype? Assume the population is under Hardy-Weinberg equilibrium.
A.
0.182
B.
0.27
C.
0.03
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0.317
E.
0.107
F.
0.09
Assume that the frequency of an allele that causes an autosomal recessive disease is 0.03. What is the probability of a person having the disease when his or her parents are unrelated (i.e., mating is random)? What is the probability of having the disease when the parents are first cousins? What about when the parents are second cousins?
The incidence of a rare autosomal recessive genetic disorder, Tay-Sachs, is approximately 1 in
3,500 in a certain population. Assuming that this population is in Hardy-Weinberg equilibrium,
what is the probability that a phenotypically normal female with no family history, and a
phenotypically normal male who had an affected great-aunt, will have a child who is a carrier for
Tay-Sachs?
Chapter 25 Solutions
Concepts of Genetics (11th Edition)
Ch. 25 - Prob. 1NSTCh. 25 - Prob. 2NSTCh. 25 - If the albino phenotype occurs in 1/10,000...Ch. 25 - A prospective groom, who is unaffected, has a...Ch. 25 - Prob. 1CSCh. 25 - Prob. 2CSCh. 25 - Prob. 3CSCh. 25 - HOW DO WE KNOW? Population geneticists study...Ch. 25 - CONCEPT QUESTION Read the Chapter Concepts list on...Ch. 25 - Price et al. [(1999).J. Bacteriol181:2358-2362)...
Ch. 25 - The genetic difference between two Drosophila...Ch. 25 - The use of nucleotide sequence data to measure...Ch. 25 - The ability to taste the compound PTC is...Ch. 25 - Prob. 7PDQCh. 25 - What must be assumed in order to validate the...Ch. 25 - In a population where only the total number of...Ch. 25 - Determine whether the following two sets of data...Ch. 25 - If 4 percent of a population in equilibrium...Ch. 25 - Consider a population in which the frequency of...Ch. 25 - If the initial allele frequencies are p = 0.5 and...Ch. 25 - Under what circumstances might a lethal dominant...Ch. 25 - Assume that a recessive autosomal disorder occurs...Ch. 25 - One of the first Mendelian traits identified in...Ch. 25 - Describe how populations with substantial genetic...Ch. 25 - Achondroplasia is a dominant trait that causes a...Ch. 25 - Prob. 19PDQCh. 25 - Prob. 20PDQCh. 25 - A botanist studying water lilies in an isolated...Ch. 25 - A farmer plants transgenic Bt corn that is...Ch. 25 - In an isolated population of 50 desert bighorn...Ch. 25 - To increase genetic diversity in the bighorn sheep...Ch. 25 - What genetic changes take place during speciation?Ch. 25 - Some critics have warned that the use of gene...Ch. 25 - A form of dwarfism known as Ellisvan Creveld...Ch. 25 - Prob. 28ESPCh. 25 - What are the two groups of reproductive isolating...Ch. 25 - The original source of new alleles, upon which...Ch. 25 - A number of comparisons of nucleotide sequences...Ch. 25 - Shown below are two homologous lengths of the...Ch. 25 - Recent reconstructions of evolutionary history are...Ch. 25 - Prob. 34ESP
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- In a hypothetical population of 2500 people, 2275 people have brown eyes and 225 people have blue eyes (the homozygous-recessive phenotype). If there are 4000 children produced by this generation, how many (i.e., what number) of the children would be expected to be heterozygous for eye color?arrow_forwardExcessive secretion of male sex hormones results in premature sexual maturation in males and masculization of the sex characters in females. This disorder is called the adrenogenital syndrome, and in Switzerland there is an autosomal recessive form of the disease that affects about one in 5000 newborns. a. Assuming random mating, what is the allele frequency of the recessive? b. What is the frequency of heterozygous carriers?arrow_forwardUse the following information to answer the next question. Galactosemia is an autosomal recessive disorder. In this disorder, the digestive system is unable to digest the sugar galactose properly. It is a rare disorder that only one in about 30 000-50 000 Caucasian children in North America and Europe are born with. The frequency of the dominant allele in a population of 35 000 children, in which 1 is suffering from galactosemia, isarrow_forward
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