Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 25, Problem 4NST
A prospective groom, who is unaffected, has a sister with cystic fibrosis (CF), an autosomal recessive disease. Their parents are normal. The brother plans to marry a woman who has no history of CF in her family. What is the probability that they will produce a CF child? They are both Caucasian, and the overall frequency of CF in the Caucasian population is 1/2500—that is, 1 affected child per 2500. (Assume the population meets the Hardy– Weinberg assumptions.)
■ HINT: This problem involves an understanding of how recessive alleles are transmitted (see Chapter 3) and the probability of receiving a recessive allele from a heterozygous parent. The key to its solution is to first work out the probability that each parent carries the mutant allele.
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A prospective groom, who is normal, has a sister with cystic fibrosis (CF), an autosomal recessive disease. Their parents are normal. The brother plans to marry a woman who has no history of CF in her family. What is the probability that they will produce a CF child? They are both Caucasian, and the overall frequency of CF in the Caucasian population is 1/2500—that is, 1 affected child per 2500. (Assume the population meets the Hardy–Weinberg assumptions.)
A prospective groom, who is unaffected, has a sisterwith cystic fibrosis (CF), an autosomal recessive disease.Their parents are unaffected. The brother plans to marrya woman who has no history of CF in her family. Whatis the probability that they will produce a CF child? Theyare both Caucasian, and the overall frequency of CF inthe Caucasian population is 1/2500—that is, 1 affectedchild per 2500. (Assume the population meets the Hardy–Weinberg assumptions.)
Travis and Marcy, a Caucasian couple, are pregnant with their first child. Travis has a prior child with cystic fibrosis (autosomal recessive). He has refused to pursue carrier testing but Marcy has had negative carrier testing. Note: Carrier testing can identify 90% of carriers of CF accurately and approximately 1/25 Caucasian's are carriers of CF. What is the chance they will have a child with CF?
1/140
1/25
1/964
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Chapter 25 Solutions
Concepts of Genetics (11th Edition)
Ch. 25 - Prob. 1NSTCh. 25 - Prob. 2NSTCh. 25 - If the albino phenotype occurs in 1/10,000...Ch. 25 - A prospective groom, who is unaffected, has a...Ch. 25 - Prob. 1CSCh. 25 - Prob. 2CSCh. 25 - Prob. 3CSCh. 25 - HOW DO WE KNOW? Population geneticists study...Ch. 25 - CONCEPT QUESTION Read the Chapter Concepts list on...Ch. 25 - Price et al. [(1999).J. Bacteriol181:2358-2362)...
Ch. 25 - The genetic difference between two Drosophila...Ch. 25 - The use of nucleotide sequence data to measure...Ch. 25 - The ability to taste the compound PTC is...Ch. 25 - Prob. 7PDQCh. 25 - What must be assumed in order to validate the...Ch. 25 - In a population where only the total number of...Ch. 25 - Determine whether the following two sets of data...Ch. 25 - If 4 percent of a population in equilibrium...Ch. 25 - Consider a population in which the frequency of...Ch. 25 - If the initial allele frequencies are p = 0.5 and...Ch. 25 - Under what circumstances might a lethal dominant...Ch. 25 - Assume that a recessive autosomal disorder occurs...Ch. 25 - One of the first Mendelian traits identified in...Ch. 25 - Describe how populations with substantial genetic...Ch. 25 - Achondroplasia is a dominant trait that causes a...Ch. 25 - Prob. 19PDQCh. 25 - Prob. 20PDQCh. 25 - A botanist studying water lilies in an isolated...Ch. 25 - A farmer plants transgenic Bt corn that is...Ch. 25 - In an isolated population of 50 desert bighorn...Ch. 25 - To increase genetic diversity in the bighorn sheep...Ch. 25 - What genetic changes take place during speciation?Ch. 25 - Some critics have warned that the use of gene...Ch. 25 - A form of dwarfism known as Ellisvan Creveld...Ch. 25 - Prob. 28ESPCh. 25 - What are the two groups of reproductive isolating...Ch. 25 - The original source of new alleles, upon which...Ch. 25 - A number of comparisons of nucleotide sequences...Ch. 25 - Shown below are two homologous lengths of the...Ch. 25 - Recent reconstructions of evolutionary history are...Ch. 25 - Prob. 34ESP
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- Tony has a sister with cystic fibrosis (CF). Neither of his parents have CF, nor does Tony. Tony is expecting a child with Tina. Tina does not have CF, but otherwise her family history is unknown. A) What is the probability that Tony is heterozygous for the CF gene? B) If the frequency of heterozygotes in the general population is 1/50, what is the probability that Tony and Tina's child will have CF?arrow_forwardTwo parents, without any family history of cystic fibrosis (CF), have a child with CF. A. What do you predict the genotypes of the parents to be? (CF is a recessive disorder.) B. What is the chance that the next child of these two parents will also have CF?arrow_forwardCystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF. a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF? b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected? c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?arrow_forward
- Give only typing answer with explanation and conclusion Travis and Marcy, a Caucasian couple, are pregnant with their first child. Travis has a prior child with cystic fibrosis (autosomal recessive). He has refused to pursue carrier testing but Marcy has had negative carrier testing. Note: Carrier testing can identify 90% of carriers of CF accurately and approximately 1/25 Caucasian's are carriers of CF. What is the chance they will have a child with CF? Group of answer choices 1/964 1/140 1/25 1/209arrow_forwardQ1: Which of the children in this Punnett square represents Zoe? What is her genotype? Q2: If Zoe’s parents had another child, what is the probability that the child would have cystic fibrosis? That the child would be a CF carrier? Q3: If Zoe is able to have a child of her own someday, and the other parent is not a carrier of cystic fibrosis (he would likely be tested before they chose to have children), what is the probability that the child would have cystic fibrosis? That the child would be a carrier?arrow_forwardSickle cell anemia is a genetically inherited autosomal recessive trait in which results in a condition that there are not enough healthy red blood cells to carry oxygen throughout the body due to the production of red blood cells that are sickle shaped. The frequency of the sickle cell condition is as high as 10% in Central Africa compared to 0.5% in the United States. Calculate the frequency of the normal and carries of the sickle cell condition.arrow_forward
- The following scenario can be seen on Ch 29 Clinical case study on Heredity (27-year-old with normal pregnancy): Mrs. Rodriguez’ blood type is type O, and her husband’s is type A. She is currently pregnant and she would like to know what type of blood her baby will have. For discussion 7 please answer the following questions: What are the genotype and phenotype of Mrs. Rodriguez? What are the genotype and phenotype of Mr. Rodriguez, given that Mr. Rodriguez’s mother has O blood type and his father has A blood type? (use Punnett Square on your worksheet to find out the genotype of Mr. Rodriquez) What is the probability that Mrs. Rodriguez’s baby will have O blood type? A? B? AB? (use Punnett Square as your worksheet) Type O =______% Type A = _____ % Type B =______% Type AB =______%arrow_forwardCystic fibrosis (CF) is an autosomal recessive trait (a). Assume that Emily (who has CF) decides to have children with a man who does not have CF and who is not a carrier of CF. What are their genotypes, and what is the probability that they will have a child who is a carrier for CF?arrow_forwardThe following is a summary of the possible sickle-cell genotypes and phenotypes: AA - cojmpletely normal AS - sickle-cell trait (this person has a combination of normal hemoglobin and the abnormal, sickled form of hemoglobin) SS - sickle-cell anemia (all abnormal hemoglobin) Make a punnett square for help answering the question: What is the probability of a couple having a child with sickle-cell trait if one parent is normal and the other has sickle-cell trait?arrow_forward
- Using the two equations, p + q = 1 and p2 + 2pq + q2 = 1, answer the following question A Hispanic-American couple wants to know their risk for having a child with cystic fibrosis. One parent has no family history of disease, but the other parent has a sibling with cystic fibrosis. Calculate the conditional probability that the couple has a child with cystic fibrosis.arrow_forwardIn humans, hemophilia is a sex-linked trait. Females can be normal, carriers, or have the disease. Males will either have the disease or not (but they won’t ever be carriers). X H X H = female, non-hemophilic X H X h = female, carrier X h X h = female, hemophilia X H Y = male, non-hemophilic X h Y= male, hemophiliac a.) Show the cross of a man who has hemophilia with a woman who is a carrier. What is the probability that their children will have the disease? b.) A woman who is a carrier marries a non-hemophilic man. Show the cross. What is the probability that their children will have hemophilia? What sex will a child in the family with hemophilia be? c.) A woman who has hemophilia marries a non-hemophilic man. How many of their children will have hemophilia, and what is their sex?arrow_forwardA couple are both phenotypically normal but their son suffers from hemophilla, a sex linked recessive disorder. What fraction of their children are likely to suffer from hemophilia. what fraction are likely to be carriers.arrow_forward
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