Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 5, Problem 27P
Male Drosophila expressing the autosomal recessive mutations sc (scute), ec (echinus), cv (crossveinless), and b (black) were crossed to
| a. | Diagram the genotype of the female parent. |
| b. | Map these loci. |
| c. | Do the data provide evidence of interference? Justify your answer with numbers. |
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Drosophila females heterozygous for three recessive mutations, a, b, and c , were crossed to males homozygous for all three mutations.The cross yielded the following results:
in the image
Q. Construct a linkage map showing the correct order of these genes and estimate the distances between them.
I. Male Drosophila from a true-breeding wild-typestock were irradiated with X-rays and then mated withfemales from a true-breeding stock carrying the following recessive mutations on the X chromosome:yellow body (y), crossveinless wings (cv), cut wings(ct), singed bristles (sn), and miniature wings (m).These markers are known to map in the order:y - cv - ct - sn - mMost of the female progeny of this cross were phenotypically wild type, but one female exhibited ct and snphenotypes. When this exceptional ct sn female wasmated with a male from the true-breeding wild-typestock, twice as many females as males appearedamong the progeny.a. What is the nature of the X-ray-induced mutationpresent in the exceptional female?b. Draw the X chromosomes present in the exceptional ct sn female as they would appear duringpairing in meiosis.c. What phenotypic classes would you expect to seeamong the progeny produced by mating the exceptional ct sn female with a normal male from a truebreeding wild-type…
In drosophila, a recessive mutation (m-) of a maternal effect gene results in an abnormal phenotype wherein homozygous (m-m-) females produce eggs that cannot support embryonic development. Homozygous (m-m-) males, however, can still produce viable sperm.
(A) Using m+ to denote a normal gene, determine the genotypes and phenotypes of the F1s produce by a cross between a heterozygous female and a recessive male.
(B) From the offspring, backcross the recessive female with the paternal strain. What are the genotypes and phenotypes of the F2s?
(C) If m-m- females produce useless eggs, then how are m-m- produced?
Chapter 5 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 5 - Choose the phrase from the right column that best...Ch. 5 - a. A Drosophila male from a true-breeding stock...Ch. 5 - Prob. 3PCh. 5 - The Punnett square in Fig. 5.4 on p. 131 shows how...Ch. 5 - In mice, the dominant allele Gs of the X-linked...Ch. 5 - In Drosophila, males from a true-breeding stock...Ch. 5 - If the a and b loci are 20 m.u. apart in humans...Ch. 5 - CCDD and ccdd individuals were crossed to each...Ch. 5 - In mice, the autosomal locus coding for the...Ch. 5 - In a particular human family, John and his mother...
Ch. 5 - Albino rabbits lacking pigment are homozygous for...Ch. 5 - In corn, the allele A allows the deposition of...Ch. 5 - If the a and b loci are 40 cM apart and an AA BB...Ch. 5 - Write the number of different kinds of phenotypes,...Ch. 5 - A DNA variant has been found linked to a rare...Ch. 5 - Figure 5.7a on p. 134 shows chromosomes during...Ch. 5 - Figure 5.7b shows bivalents in mouse primary...Ch. 5 - Cinnabar eyes cn and reduced bristles rd are...Ch. 5 - In Drosophila, the autosomal recessive dp allele...Ch. 5 - From a series of two-point crosses, the following...Ch. 5 - Map distances were determined for four different...Ch. 5 - In the tubular flowers of foxgloves, wild-type...Ch. 5 - In Drosophila, the recessive allele mb of one gene...Ch. 5 - A snapdragon with pink petals, black anthers, and...Ch. 5 - In Drosophila, three autosomal genes have the...Ch. 5 - Drosophila females heterozygous for each of three...Ch. 5 - Male Drosophila expressing the autosomal recessive...Ch. 5 - a. In Drosophila, crosses between F1 heterozygotes...Ch. 5 - A true-breeding strain of Virginia tobacco has...Ch. 5 - Prob. 30PCh. 5 - The following list of four Drosophila mutations...Ch. 5 - Do the data that Mendel obtained fit his...Ch. 5 - Two genes control color in corn snakes as follows:...Ch. 5 - A mouse from a true-breeding population with...Ch. 5 - Neurospora of genotype a c are crossed with...Ch. 5 - A cross was performed between one haploid strain...Ch. 5 - A cross was performed between a yeast strain that...Ch. 5 - Two crosses were made in Neurospora involving the...Ch. 5 - Indicate the percentage of tetrads that would have...Ch. 5 - Prob. 42PCh. 5 - Prob. 43PCh. 5 - Prob. 44PCh. 5 - a. In ordered tetrad analysis, what is the maximum...Ch. 5 - A research group has selected three independent...Ch. 5 - A single yeast cell placed on a solid agar will...Ch. 5 - Prob. 48PCh. 5 - In Drosophila, the yellow y gene is near the end...Ch. 5 - Neurofibromas are tumors of the skin that can...Ch. 5 - Two important methods for understanding the...
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- In Drosophila melanogaster white (w) and miniature (m) wings are controlled by X-linked recessive genes with a recombination fruequency between them of approximately 38%. Show the sexes, phenotypes and proportions of offspring expected from the following mating:a. ++/wm female X wm maleb. +m/w+ female X w+ malec. w+/+m female X ++ maleIf we assume that white eyes and miniature wings are not x-linked but are linkedto the autosomal genes, what phenotypic frequencies would you expect from this cross: ++/wm female X ++/wm male?arrow_forwardBlack body (b) and purple eye (pr) are recessive autosomal mutations in Drosophila. Bridges are crossed b/b females with pr/pr males and in the F2 observed 684 wild type, 371 black-bodied, and 300 purple-eyed flies. Do these results indicate that the b and pr genes are closely linked? Explain. (Remember that there is no crossing-over in male Drosophila)..arrow_forwardIn Drosophila, three autosomal genes have the following map:20 m.u. 10 m.u.a b ca. Provide the data, in terms of the expected numberof flies in the following phenotypic classes, whena+ b+ c+/ a b c females are crossed to a b c / a b c males. Assume 1000 flies are counted and that nointerference exists in this region.a+ b+ c+a b ca+ b ca b+ c+a+ b+ ca b c+a+ b c+a b+ cb. If the cross was reversed, such that a+ b+ c+ / a b cmales are crossed to a b c / a b c females, howmany flies would you expect in the same phenotypic classes?arrow_forward
- The Drosophila gene Sex lethal (Sxl) is deserving of itsname. Certain alleles have no effect on XY animals butcause XX animals to die early in development. Other alleles have no effect on XX animals but cause XY animals to die early in development. Thus, some Sxl allelesare lethal to females, while others are lethal to males.a. Would you expect a null mutation in Sxl to causelethality in males or in females? b. Why do Sxl alleles of either type cause lethality ina specific sex?The gene transformer (tra) gets its name from sexualtransformation, as some tra alleles can change XXanimals into morphological males, while other traalleles can change XY animals into morphologicalfemales.c. Which of these sex transformations would becaused by null alleles of tra and which would becaused by constitutively active alleles of tra?d. In contrast with Sxl, null tra mutations do notcause lethality either in XX or in XY animals.However, the Sxl protein regulates the productionof the Tra protein. Why…arrow_forwardA mutation of Drosophila has a wing condition known as beaded. When a beaded fly was crossed with a pure-line normal fly, 53 beaded and 47 normal F1 's were produced. When two of the F, beaded flies were mated, 67 beaded and 33 normal F2's were produced. Explain the genetics of the beaded trait and give the genotypes of all P and F1 generation flies.arrow_forwardIn Drosophila, a female fly is heterozygous for three mutations, Bareyes (B), miniature wings (m), and ebony body (e). Note that Bar isa dominant mutation. The fly is crossed to a male with normal eyes,miniature wings, and ebony body. The results of the cross are asfollows.111 miniature29 wild type117 Bar26 Bar, mimatue101 Bar, ebony31 Bar, miniature, ebony35 ebony115 miniature, ebonyInterpret the results of this cross. If you conclude that linkage isinvolved between any of the genes, determine that map distance(sbetween them.arrow_forward
- Determine whether the expression of wild type lacZ and lacy would be "inducible," "uninducible" or "constitutive" in examples A and B. A is a haploid genotype and B is a partial diploids. A. lacl-lacO+ lacZ+ lacY- B. A. LacZ: Select] B. LacZ: [Select] lacl-lacO+ lacZ- lacY+ lacl+ lacO+ lacZ-lacY+ ; LacY: [Select ] ; Lac✓ [Select] constitutive inducible uninduciblearrow_forwardA Drosophila strain with two mutated phenotypes was crossed with a wild-type Drosophila strain. The wild-type phenotypes were present in all of the F1 flies. The F1 flies were bred with one another. The F2 generation, on the other hand, did not have the predicted 9:3:3:1 phenotypic ratio. Explain why these outcomes occurred.arrow_forwardIn Drosophila, a heterozygous female for the X-linkedrecessive traits a, b, and c was crossed to a male that phenotypically expressed a, b, and c. The offspring occurred inthe following phenotypic ratios.+ b c 460a + + 450a b c 32+ + + 38a + c 11+ b + 9 No other phenotypes were observed.(a) Determine the correct sequence and construct amap of these genes on the X chromosome ?arrow_forward
- a. What is the Raly gene? What does it encode? How does it relate to the lethality of Ay? b. A heterozygous mouse AAy does not produce enough pigment and it is yellow. Homozygous individuals die during development, but AAy heterozygous do not. Why? You may use any graphic aid to explain this, if necessary. This means that you may use a Punnett square or a forking segregation diagram, or computations with fractions. c. Explain why there is a non-Mendelian 2:1 yellow/agouti phenotypic ratio in this cross.arrow_forwardExplain the following: a- No parental type is produced during gametogenesis? b- A dominant wild type produced a sign spot in Drosophila? c- 9:7 phenotypic ratio is produced in dihybrid cross? d- 50% parental type gametes were produced during gametogenesis? e- All recombinant gametes were produced during gametogenesis?arrow_forwardFemale Drosophila heterozygous for three recessive mutations e (ebony body), st (scarlet eyes), and ss (spineless bristles) were testcrossed, and the following progeny were obtained: Phenotype Number wild-type 67 ebony 8 ebony, scarlet 68 ebony, spineless 347 ebony, scarlet, spineless 78 scarlet 368 scarlet, spineless 10 spineless 54 (a) What indicates that the genes are linked? (b) What was the genotype of the original heterozygous females? (c) What is the order of the genes? (d) What is the map distance between e and st? (e) Between e and ss? (f) What is the coefficient of coincidence? (g) Diagram the crosses in this experiment.arrow_forward
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