Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 5, Problem 15P
A DNA variant has been found linked to a rare autosomal dominant disease in humans and can thus be used as a marker to follow inheritance of the disease allele. In an informative family (in which one parent is heterozygous for both the disease allele and the DNA marker in a known chromosomal arrangement of alleles, and his or her mate does not have the same alleles of the DNA variant), the reliability of such a marker as a predictor of the disease in a fetus is related to the map distance between the DNA marker and the gene causing the disease. Imagine that a man affected with the disease (genotype Dd) is heterozygous for the V1 and V2 forms of the DNA variant, with form V1 on the same chromosome as the D allele and form V2 on the same chromosome as d. His wife is V3V3dd, where V3 is another allele of the DNA marker. Typing of the fetus by amniocentesis reveals that the fetus has the V2 and V3 variants of the DNA marker. How likely is it that the fetus has inherited the disease allele D if the distance between the D locus and the marker locus is (a) 0 m.u., (b) 1 m.u., (c) 5 m.u., (d) 10 m.u., (e) 50 m.u.?
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Chapter 5 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 5 - Choose the phrase from the right column that best...Ch. 5 - a. A Drosophila male from a true-breeding stock...Ch. 5 - Prob. 3PCh. 5 - The Punnett square in Fig. 5.4 on p. 131 shows how...Ch. 5 - In mice, the dominant allele Gs of the X-linked...Ch. 5 - In Drosophila, males from a true-breeding stock...Ch. 5 - If the a and b loci are 20 m.u. apart in humans...Ch. 5 - CCDD and ccdd individuals were crossed to each...Ch. 5 - In mice, the autosomal locus coding for the...Ch. 5 - In a particular human family, John and his mother...
Ch. 5 - Albino rabbits lacking pigment are homozygous for...Ch. 5 - In corn, the allele A allows the deposition of...Ch. 5 - If the a and b loci are 40 cM apart and an AA BB...Ch. 5 - Write the number of different kinds of phenotypes,...Ch. 5 - A DNA variant has been found linked to a rare...Ch. 5 - Figure 5.7a on p. 134 shows chromosomes during...Ch. 5 - Figure 5.7b shows bivalents in mouse primary...Ch. 5 - Cinnabar eyes cn and reduced bristles rd are...Ch. 5 - In Drosophila, the autosomal recessive dp allele...Ch. 5 - From a series of two-point crosses, the following...Ch. 5 - Map distances were determined for four different...Ch. 5 - In the tubular flowers of foxgloves, wild-type...Ch. 5 - In Drosophila, the recessive allele mb of one gene...Ch. 5 - A snapdragon with pink petals, black anthers, and...Ch. 5 - In Drosophila, three autosomal genes have the...Ch. 5 - Drosophila females heterozygous for each of three...Ch. 5 - Male Drosophila expressing the autosomal recessive...Ch. 5 - a. In Drosophila, crosses between F1 heterozygotes...Ch. 5 - A true-breeding strain of Virginia tobacco has...Ch. 5 - Prob. 30PCh. 5 - The following list of four Drosophila mutations...Ch. 5 - Do the data that Mendel obtained fit his...Ch. 5 - Two genes control color in corn snakes as follows:...Ch. 5 - A mouse from a true-breeding population with...Ch. 5 - Neurospora of genotype a c are crossed with...Ch. 5 - A cross was performed between one haploid strain...Ch. 5 - A cross was performed between a yeast strain that...Ch. 5 - Two crosses were made in Neurospora involving the...Ch. 5 - Indicate the percentage of tetrads that would have...Ch. 5 - Prob. 42PCh. 5 - Prob. 43PCh. 5 - Prob. 44PCh. 5 - a. In ordered tetrad analysis, what is the maximum...Ch. 5 - A research group has selected three independent...Ch. 5 - A single yeast cell placed on a solid agar will...Ch. 5 - Prob. 48PCh. 5 - In Drosophila, the yellow y gene is near the end...Ch. 5 - Neurofibromas are tumors of the skin that can...Ch. 5 - Two important methods for understanding the...
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