Microbiology: An Introduction
12th Edition
ISBN: 9780321929150
Author: Gerard J. Tortora, Berdell R. Funke, Christine L. Case
Publisher: PEARSON
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Chapter 8, Problem 1CAE
Ciprofloxacin, erythromycin, and acyclovir are used to treat microbial infections. Ciprofloxacin inhibits DNA gyrase. Erythromycin binds in front of the A site on the 50S subunit of a ribosome. Acyclovir is a guanine analog.
- a. What steps in protein synthesis are inhibited by each drug?
- b. Which drug is more effective against bacteria? Why?
- c. Which drugs will have effects on the host’s cells? Why?
- d. Use the index to identify the disease for which acyclovir is primarily used. Why is it more effective than erythromycin for treating this disease?
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(61) A 61-year old woman comes to the physician because of scarring acne vulgaris that has not been responsive to topical medication. Oral tetracycline is prescribed . Which of the following best explains the mechanism of action of this drug?
(A) Blockage of DNA gyrase
(B) Destruction of active transport membrane transport
(C) Inhibition of aminoacyl-RNA binding to bacterial ribosomes
(D) Interference with the action of peptidyl transferase
(E) Interferance with translocation reaction
Which of the following statements regarding Anfinsen's denaturing experiments with ribonuclease A are valid?
(i) Exposing the denatured protein to air oxidation and then dialysis to remove urea restored the protein to its original functionality.
(ii) Removing urea by dialysis and then allowing air oxidation of the denatured protein restored the protein to its original functionality.
(iii) Denaturing the protein with both urea and β-mercaptoethanol yielded an inactive protein.
(iv) Protein folding is determined by its primary sequence.
Ribonuclease A cannot catalyze the hydrolysis of DNA.
which of the following statements explains it.
a. Ribonuclease requires two active site histidines to be active but the nucleobase of DNA will form hydrogen bonds with these histidines and block their acid-base catalysis.
b. DNAs have thymidine that is more stable than the uracil in RNAs
c. DNAs are double-stranded and the nucleobases are protected while RNAs are single stranded
d. DNAs does not have hydroxyl group at 2' position of the sugar ring to support the catalysis
Chapter 8 Solutions
Microbiology: An Introduction
Ch. 8 - Briefly describe the components of DNA, and...Ch. 8 - DRAW IT Identify and mark each of the following on...Ch. 8 - Match the following examples of mutagens. Column A...Ch. 8 - The following is a code for a strand of DNA. a....Ch. 8 - Identify when (before transcription, after...Ch. 8 - Which sequence is the best target for damage by UV...Ch. 8 - You are provided with cultures with the following...Ch. 8 - Why are mutation and recombination important in...Ch. 8 - NAME IT Normally a commensal in the human...Ch. 8 - Match the following terms to the definitions in...
Ch. 8 - Match the following terms to the definitions in...Ch. 8 - Feedback inhibition differs from repression...Ch. 8 - Bacteria can acquire antibiotic resistance by all...Ch. 8 - Suppose you inoculate three flasks of minimal...Ch. 8 - Plasmids differ from transposons in that plasmids...Ch. 8 - Mechanism by which the presence of glucose...Ch. 8 - The mechanism by which lactose controls the lac...Ch. 8 - Two offspring cells are most likely to inherit...Ch. 8 - Which of the following is not a method of...Ch. 8 - Nucleoside analogs and ionizing radiation are used...Ch. 8 - Replication of the E. coli chromosome takes 40 to...Ch. 8 - Pseudomonas has a plasmid containing the mer...Ch. 8 - Ciprofloxacin, erythromycin, and acyclovir are...Ch. 8 - HIV, the virus that causes AIDS, was isolated from...Ch. 8 - Human herpesvirus-8 (HHV-8) is common in parts of...
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