Chemistry In Context
Chemistry In Context
9th Edition
ISBN: 9781259638145
Author: Fahlman, Bradley D., Purvis-roberts, Kathleen, Kirk, John S., Bentley, Anne K., Daubenmire, Patrick L., ELLIS, Jamie P., Mury, Michael T., American Chemical Society
Publisher: Mcgraw-hill Education,
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Chapter 12.10, Problem 12.32YT

See for yourself the shapes of drug molecules by visiting 3Dchem.com. On screen, you can rotate three-dimensional representations of best-selling drugs such as amoxicillin, Lipitor®, and ibuprofen.

  1. a. Select several drugs and examine their three-dimensional structure. How do these computer representations differ from the structural formulas of drugs shown in this chapter?
  2. b. What advantages do the computer representations have over two-dimensional drawings? What are their limitations compared with “real” molecules? Are there any disadvantages?
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TRUE OR FALSE All atoms play a role in the physicochemical and pharmacologic properties of a molecule. Sophistication and advancement in technology are the main driving forces of drug development. Organic medicinal chemistry is the study of matter, specifically, all carbon-containing compounds. A functional group will always have the same physicochemical properties, regardless of its neighboring atoms in a molecular structure. Addition of a single methyl group in a drug molecule may result to changes in physical, chemical, pharmacokinetic, and pharmacologic properties. Steric effects occur when bulky and large functional groups are near each other in a molecular structure. Molecules that are highly capable of hydrogen bonding tend to be more soluble in nonpolar solvents.
The synthesis of aspirin is a common esterification reaction. It is based on the balanced reaction given in the background of this lab. Calculate the theoretical yield of aspirin given that 3.52-mL of acetic anhydride was reacted with 0.9457-g of salicylic acid. Synthesized solids often need to be purified prior to use. What are some ways you could purify synthesized aspirin in the laboratory? Explain why you would not expect to smell acetic acid after the addition of sodium bicarbonate to the esterification reaction mixture.
Ticlopidine is antiplatelet drug used to prevent strokes See image below

Chapter 12 Solutions

Chemistry In Context

Ch. 12.3 - Prob. 12.12YTCh. 12.4 - Prob. 12.13YTCh. 12.4 - Skill Building Functional Groups in Dopamine Draw...Ch. 12.4 - Prob. 12.15YTCh. 12.5 - Prob. 12.16YTCh. 12.5 - Prob. 12.17YTCh. 12.6 - Prob. 12.18YTCh. 12.6 - Prob. 12.19YTCh. 12.6 - The structures of proteins, such as the ones shown...Ch. 12.7 - Reconsider your work in past chapters. List three...Ch. 12.7 - Prob. 12.22YTCh. 12.7 - Prob. 12.23YTCh. 12.8 - Prob. 12.24YTCh. 12.8 - Prob. 12.25YTCh. 12.9 - Skill Building Ester Formation Draw structural...Ch. 12.9 - Prob. 12.27YTCh. 12.9 - You Decide Supersize My Aspirin A friend who...Ch. 12.9 - Modern methods of drug discovery involve...Ch. 12.10 - Make two lists of drugs for each of the two...Ch. 12.10 - See for yourself the shapes of drug molecules by...Ch. 12.10 - Prob. 12.33YTCh. 12.10 - Prob. 12.34YTCh. 12 - Scientific Practices Follow the Hormone Using the...Ch. 12 - The field of chemistry has many sub-disciplines....Ch. 12 - Prob. 2QCh. 12 - Prob. 4QCh. 12 - Nitrous acid (HNO2) has a Ka value of 4.0 10 4,...Ch. 12 - Use the Henderson-Hasselbalch equation and Table...Ch. 12 - Write the structural formula and line-angle...Ch. 12 - Prob. 8QCh. 12 - Prob. 9QCh. 12 - Prob. 10QCh. 12 - Prob. 11QCh. 12 - Prob. 12QCh. 12 - Estradiol is relatively insoluble in water but...Ch. 12 - Prob. 14QCh. 12 - Prob. 15QCh. 12 - Prob. 16QCh. 12 - Define and relate the two terms: hormone and...Ch. 12 - Refer to Figure 11.17. Select two examples of...Ch. 12 - Prob. 19QCh. 12 - Molecules as diverse as cholesterol, sex hormones,...Ch. 12 - Prob. 21QCh. 12 - Prob. 22QCh. 12 - Prob. 23QCh. 12 - Sulfanilamide is the simplest sulfa drug, a type...Ch. 12 - Explain why an equilibrium constant cannot tell...Ch. 12 - Use the information in Table 12.1 to redraw Figure...Ch. 12 - Draw structural formulas for each of these...Ch. 12 - In Your Turn 12.12, you were asked to draw...Ch. 12 - Prob. 29QCh. 12 - Prob. 30QCh. 12 - Prob. 31QCh. 12 - Prob. 32QCh. 12 - Prob. 34QCh. 12 - Prob. 35QCh. 12 - Prob. 36QCh. 12 - Prob. 37QCh. 12 - Prob. 38QCh. 12 - The text states that some racemic mixtures contain...Ch. 12 - Prob. 40QCh. 12 - Prob. 41QCh. 12 - Prob. 44QCh. 12 - Prob. 47QCh. 12 - Prob. 49QCh. 12 - Dorothy Crowfoot Hodgkin first determined the...Ch. 12 - Prob. 52Q
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