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Concept explainers
Interpretation: To identify the correct order in which
Concept introduction: Common metabolic pathway is the total sum of metabolic reactions that occur in stage third and fourth of the biochemical process or it is defined as the total sum of reactions that occur in the citric acid cycle and electron transport chain and oxidative phosphorylation.
These stages are included in the common metabolic pathway because the reactions in these stages are the same for different kinds of food.
The citric acid cycle is the third stage of the biochemical energy production process. The cycle includes the reactions in which the acetyl part of acetyl CoA is oxidized and leads to the formation of carbon dioxide and
Electron transport chain is a sequence of biochemical reactions in which electrons and hydrogen atoms from the citric acid cycle are transferred to various intermediate carriers and finally reacts with molecular oxygen to form a water molecule.
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Chapter 23 Solutions
EBK GENERAL, ORGANIC, AND BIOLOGICAL CH
- Corticosteroids (a type of hormone), and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) are non-narcotic pain relievers. Both medications are prescribed to reduce inflammation in the body. NSAIDs such as aspirin, acetaminophen, and ibuprofen are able to reduce pain, fever, and inflammation by blocking the action of the cyclooxygenase enzyme (COX) that catalyzes the conversion of arachidonic acid into prostaglandins. Common corticosteroids include prednisone, cortisone, and methylprednisolone. Choose one of these three corticosteroids. The corticosteroid that you choose and then explain how the drug works to reduce inflammation.arrow_forwardCorticosteroids (a type of hormone), and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) are non-narcotic pain relievers. Both medications are prescribed to reduce inflammation in the body. NSAIDs such as aspirin, acetaminophen, and ibuprofen are able to reduce pain, fever, and inflammation by blocking the action of the cyclooxygenase enzyme (COX) that catalyzes the conversion of arachidonic acid into prostaglandins. Common corticosteroids include prednisone, cortisone, and methylprednisolone. Choose one of these three corticosteroids. Do some internet research on the corticosteroid that you choose and then explain how the drug works to reduce inflammation.arrow_forwardGiven the following enzyme catalyzed reaction, identify the class and subclass of the enzyme involved: NADH NAD* + H* C-O C-OT C=0 H-C-OH CH CH Class: Subclass:arrow_forward
- Which type of enzyme (Table) catalyzes the following (given) reactions?arrow_forwardThiamine is the vitamin precursor for a co-enzyme called thiamine pyrophosphate or TPP. A patient diagnosed with thiamine deficiency exhibited fatigue and muscle cramps. The muscle cramps have been related to the accumulation of specific metabolic acids. On the following list, circle the metabolic acids that are most likely to accumulate in a thiamine deficiency? Note: There may be more than one. Isocitrate Pyruvate Succinate α-ketoglutarate Malate Fumarate (b) Provide a brief explanation for your answer to 1 (a) herearrow_forwardmatch the cofactor with its function in the citric acid cycle by entering the number corresponding with the function. A given function may be used more than one time or not at all. Use from the following list of functions to fill in the table below: carries O2 carries small carbon-containing molecules carries e- carries small nitrogen-containing molecules Cofactor Function NAD+/NADH FAD/FADH2 CoA thiamine biotinarrow_forward
- The glutamate dehydrogenase (GDH) catalyses the following reaction: +H₂N- H - - CH₂ - CH₂ COO acide glutamique COO™® + NAD+ + H₂O GDH COO C: CH₂ CH₂ COO™ O + NH4+ NADH + H* The activity of GDH is monitored in the sense of the formation of glutamate using the following conditions: -0.2 mL of 5 M ammonium sulphate 2.4 mL of buffer at pH 8 0.1 mL of NADH at 6.15 mg.mL-¹ (M = 709 g.mol-¹) 0.2 mL of 1 M a-ketoglutarate solution Warm mixture at 25 °C for 5 min - Add 0.1 mL of GDH solution containing 1.6 mg.mL-¹protein to start the reaction. acide a-cétoglutarique The change in absorbance at 340 nm is monitored, in a 1-cm cuvette, every minute for 10 min. Results are given in the table below: Data: ENADH at 340 nm = 6220 M¹.cm¹ Time (min) 1 2 3 4 5 6 7 8 9 1.760 1.718 1.675 1.635 1.595 1.550 1.510 1.489 1.476 A340 10 1.451 - Draw the graph A = f(t). Calculate A340 at t = 0 and place this point on the curve. - Comment the shape of the curve, particularly the portion that corresponds to a…arrow_forwardThe enzyme which catalyzes the reaction below belongs to which enzyme classification? || C-0- HC=0 + CO2 C=0 CH3 CH Hydrolase Oxidoreductase Ligase O Lyasearrow_forwardWhat class of enzyme catalyzes the following?arrow_forward
- In the living cell, free energy made from one reaction can be used to drive another in an energetically unfavorable direction, provided the two reactions have a common intermediate (this is termed the principle of common intermediates). Example: In glycolysis, glucose is converted into pyruvate; in gluconeogenesis, pyruvate is converted into glucose. However, the actual ΔG for the formation of pyruvate from glucose is about -84 kJ/mol under typical cellular conditions. Most of the decrease in free energy in glycolysis takes place in three essentially irreversible steps catalyzed by, hexokinase, pyruvate kinase and phosphofructokinase. Use one of the 3 opposing reactions (in glycolysis and gluconeogenesis) to demonstrate the PRINCIPLE OF COMMON INTERMEDIATESarrow_forwardSodium fluoroacetate (FH2CCOO- Na+) is highly toxic. Patients with fluoroacetate poisoning accumulate citrate and fluorocitrate in their cells. Which enzyme is inhibited by fluoroacetate for this to occur? Explain.arrow_forwardPhosphofructokinase (PFK-1) is one of the most regulated enzymes in metabolism. Based on all of the principles we have learned in this class, which of the following would be most likely to be an allosteric activator of PFK-1? a Pyruvate b Acetyl CoA c Citric acid d glucosearrow_forward
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