Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 5, Problem 18P
The
a. From these data, can you conclude that Rh and
b. What is
c. Over what range of w do lod scores indicate significantevidence in favor of genetic linkage?
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Classical hemophilia is a sex-linked disease caused by a recessive gene on the X chromosome. (Hemophilia refers to diseases that cause delays in blood clotting.) If a woman who is acarrierof classical hemophilia has children with a normal male, give the ratios of the possible offspring with respect to classical hemophilia. Be sure to state both the genotypes and the phenotypes of each offspring. For genotypes, use X for a normal X chromosome, Xh for an X chromosome with the hemophilia gene, and Y for a normal Y chromosome. For phenotypes, if the offspring is female, be sure to state if homozygous normal, a carrier, or has the disease. If the offspring is a male, be sure to state if normal or has the disease.
In humans, the allele for normal blood clotting (H) is dominant to the allele for hemophilia. This is a sex-linked trait found on the X chromosome. A woman with normal blood clotting has four children: a normal son, a hemophiliac son, and two normal daughters. The father has normal blood clotting. What is the probable genotype for each member of the family?
Hemophilia is an X-linked disease associated with the inability to produce specific proteins in the blood-clotting pathway. Shown above is a family pedigree tree in which family members afflicted with the disease are shown with filled-in squares (male) or circles (females). A couple is trying to determine the likelihood of passing on the disease to their future children (represented by the ? symbol above) because the hemophilia runs in the woman’s family
4.Assuming that the woman in the couple is a carrier, what is the probability that the couple’s first son will have hemophilia?
Chapter 5 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 5 - For parts a, b, and c, draw a diagram illustrating...Ch. 5 - 5.2 In a diploid species of plant, the genes for...Ch. 5 - A pure-breeding tall plant producing oval fruit as...Ch. 5 - 5.4 Genes E and H are syntenic in an experimental...Ch. 5 - In tomato plants, purple leaf color is controlled...Ch. 5 - 5.6 In Drosophila, the map positions of genes are...Ch. 5 - 5.7 Genes A, B, and C are linked on a chromosome...Ch. 5 - Gene G recombines with gene T at a frequency of...Ch. 5 - Genes A, B, C, D, and E are linked on a...Ch. 5 - Syntenic genes can assort independently. Explain...
Ch. 5 - The recombination frequency between linked genes...Ch. 5 - On the DrosophilaX chromosome, the dominant allele...Ch. 5 - Researchers cross a corn plant that is pure -...Ch. 5 - 5.14 syndrome is an autosomal disorder affecting...Ch. 5 - 5.15 Three dominant traits of corn seedlings,...Ch. 5 - 5.16 In a diploid plant species, an with the...Ch. 5 - Prob. 17PCh. 5 - The Rh blood group in humans is determined by a...Ch. 5 - 5.19 Genetic linkage mapping for a large number of...Ch. 5 - 20. Neurospora with the genotype form tetrads in...Ch. 5 -
Gene and gene are genetically linked. Answer...Ch. 5 -
T. H. Morgan’s data on eye color and wing form,...Ch. 5 - Prob. 23PCh. 5 -
The boss in your laboratory has just heard of a...Ch. 5 - In rabbits, chocolate-colored fur (w+) is dominant...Ch. 5 - Prob. 26PCh. 5 - 5.27 In tomatoes, the allele for tall plant height...Ch. 5 - 5.28 Neurofibromatosis is an autosomal dominant...Ch. 5 - A 2006 genetic study of a large American family...Ch. 5 - 5.30 A experiment examining potential genetic...Ch. 5 - 31. As part of their analysis of intragenic...Ch. 5 - In experiments published in 1918 that sought to...
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- An allele responsible for Marfan syndrome Section 13.4 is inherited in an autosomal dominant pattern. What is the chance that a child will inherit the allele if one parent does not carry it and the other is heterozygous?arrow_forwardIn individuals affected by cystic fibrosis, salt crystals may appear afterperspiration dries up. In addition, the disease causes respiratory disorderswhich can be both debilitating and lethal. It occurs in individuals homozygousfor the recessive gene. Two normal parents had a daughter with thesymptoms of this disease, and a normal son who marries a normal womanwith an afflicted A test (salt concentration in perspiration of heterozygotes ishigher than normal) disclosed that both are indeed carriers of the gene. If thefirst child born to the mating in (b) was defective, what is the probability thatthe 2nd child would also be defective?Express answer in fraction formarrow_forwardCystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of sticky mucus that clogs the lungs and pancreas. It is a life-threatening disease, but medical advances helped the afflicted to live through adulthood. Betty's mother died from cystic fibrosis, but her father was normal and never had any relative with CF. Her fiancé, Jones, turned out to be a carrier of the CF allele. What are the genotypes of Betty and Jones? 1. Betty: ________________________ 2. Jones: _____________________ They planned to have four children. What is the probability that: 3. all children will be normal 4. at least two will be normalarrow_forward
- The XG locus on the human X chromosome has twoalleles, XG+ and XG. The XG+ allele causes the presence of the Xg surface antigen on red blood cells,while the recessive XG allele does not allow antigento appear. The XG locus is 10 m.u. from the STSlocus. The STS+ allele produces normal activity ofthe enzyme steroid sulfatase, while the recessive STSallele results in the lack of steroid sulfatase activityand the disease ichthyosis (scaly skin). A man withichthyosis and no Xg antigen has a normal daughterwith Xg antigen. This daughter is expecting a child.a. If the child is a son, what is the probability he willlack Xg antigen and have ichthyosis?b. What is the probability that a son would have boththe antigen and ichthyosis?c. If the child is a son with ichthyosis, what is theprobability he will have Xg antigen?arrow_forwardMales have hemophilia when they are hemizygous for a nonfunctional recessive mutant allele of the X-linked gene for clotting factor VIII. Factor VIII is normally secreted into the blood serum by cells in the bone marrow (and other specialized cells) that produce it. a. Do you think that females heterozygous for the hemophilia disease allele could have hemophilia in some parts of their bodies and not others?arrow_forwardCystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of stickymucus that clogs the lungs and pancreas. It is a life-threatening disease, but medical advances helpedthe afflicted to live through adulthood. The mother of Claudia died from cystic fibrosis, but her father was normal and never had anyrelative with CF. Her fiancé, Marcus, turned out to be a carrier of the CF allele. What are the genotypes of Claudia and Marcus? Claudia: ________________________ Marcus: _____________________ They planned to have four children. What is the probability that:a. all children will be normal b. at least two will be normalarrow_forward
- Sickle cell anemia is inherited as an autosomal recessive condition. It also exhibits incomplete dominance in that the heterozygous genotype displays a mild form of the disease known as sickle cell trait while individuals with the homozygous recessive genotype have a severe form of SCA. A man who has severe sickle cell anemia marries a woman who suffers from a mild trait. What is the probabilitu they will have a child with severe SCA?What is the probability they will have a child with mild SCA? What is the probability they will have a normal child? Show ALL work using punnett squares.arrow_forwardThe gene for polydactyly (P) is autosomal and dominant to normal fingers (p). Hemophilia is sex-linked and recessive (X h ). A man and his wife both of whom are polydactylous and have normal red blood cells have a child who is non-polydactylous and with hemophilia. What are their genotypes?arrow_forwardIn humans, the allele for normal blood clotting, H, is dominant to the allele for hemophilia, h. This is a sex-linked trait found on the X chromosome. A woman with normal blood clotting has four children: a normal son, a hemophiliac son, and two normal daughters. The father has normal blood clotting. What is the genotype for each member of the family?arrow_forward
- Hemophilia A is caused by a recessive X-linked allele that encodes a defective form of a clotting protein. If a affected father and a mother who is known to not be a carrier have children, what percentage of female offspring will have hemophilia?arrow_forwardSeveral genes in humans in addition to the ABO gene(I) give rise to recognizable antigens on the surface ofred blood cells. The MN and Rh genes are two examples. The Rh locus can contain either a positive or anegative allele, with positive being dominant to negative. M and N are codominant alleles of the MN gene.The following chart shows several mothers and theirchildren. For each mother-child pair, choose the fatherof the child from among the males in the right column, assuming one child per male.Mother Child Malesa. O M Rh(pos) B MN Rh(neg) O M Rh(neg)b. B MN Rh(neg) O N Rh(neg) A M Rh(pos)c. O M Rh(pos) A M Rh(neg) O MN Rh(pos)d. AB N Rh(neg) B MN Rh(neg) B MN Rh(pos)arrow_forwardMutations in the genes for clotting factor VIII and IX cause hemophilia A and B, respectively. A woman may be heterozygous for mutations in both genes, with a mutated factor VIII allele on one X chromosome, and a mutated factor IX allele on the other. All of her sons should have either hemophilia A or B. However, on rare occasions, one of these women gives birth to a son who does not have hemophilia, and his one X chromosome does not have either mutated allele. Explain.arrow_forward
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