Genetic Analysis: An Integrated Approach (2nd Edition)
Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 5, Problem 29P

A 2006 genetic study of a large American family (Ikeda et al ., 2006 ) identified genetic linkage between DNA markerson chromosome 11 and the gene producing the autosomal

dominant neuromuscular disorder spinocerebellar ataxiatype ( SCA5 ) . The following lod score data are taken fromthe 2006 study:

T h e t a ( θ ) V a l u e 0.01 0.05 0.10 0.20 0.30 0.40 SCASandDNA markerA 11.02 12.26 11.94 10.04 7.26 3.77 SCASandDNA markerB 0.35 0.94 1.07 0.99 0.75 0.43

Does either group of lod scores indicate statisticallysignificant odds in favor of genetic linkage? Explainyour answer.

What is the maximum value for each set of lod scores?

Based on the available information, is DNA marker A linked to the gene producing SCA5 ? Explain youranswer.

Based on available information, is DNA marker B linked to the gene for SCA5 ? Explain your answer

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Genetic Analysis: An Integrated Approach (2nd Edition)

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