Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 7, Problem 20P
The mutant FMR-1 allele that causes fragile X syndrome is considered to be X-linked dominant with incomplete penetrance and variable expressivity. Why do most females heterozygous for one mutant and one normal allele have at least some symptoms of the disease?
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Chapter 7 Solutions
Genetics: From Genes to Genomes
Ch. 7 - The following is a list of mutational changes. For...Ch. 7 - What explanations can account for the following...Ch. 7 - The DNA sequence of one strand of a gene from...Ch. 7 - Among mammals, measurements of the rate of...Ch. 7 - Over a period of several years, a large hospital...Ch. 7 - Suppose you wanted to study genes controlling the...Ch. 7 - In a genetics lab, Kim and Maria infected a sample...Ch. 7 - The results of the fluctuation test Fig. 7.5 were...Ch. 7 - The following pedigree shows the inheritance of a...Ch. 7 - Autism is a neurological disorder thought to be...
Ch. 7 - Like the yellow Labrador retrievers featured in...Ch. 7 - Remember that Balancer chromosomes prevent the...Ch. 7 - Figure 7.14 shows examples of base substitutions...Ch. 7 - Figure 7.14a shows the mutagen 5-bromouracil 5-BU,...Ch. 7 - So-called two-way mutagens can induce both a...Ch. 7 - In 1967, J. B. Jenkins treated wild-type male...Ch. 7 - When a particular mutagen identified by the Ames...Ch. 7 - Prob. 18PCh. 7 - The Ames test uses the reversion rate His- to His...Ch. 7 - The mutant FMR-1 allele that causes fragile X...Ch. 7 - The physicist Stephen Hawking, famous for his...Ch. 7 - Aflatoxin B1 is a highly mutagenic and...Ch. 7 - In human DNA, 70 of cytosine residues that are...Ch. 7 - Bromodeoxyuridine BrdU is a synthetic nucleoside...Ch. 7 - Albinism in animals is caused by recessive...Ch. 7 - a. In Figure 7.22b, what can you say about the...Ch. 7 - Imagine that you caught a female albino mouse in...Ch. 7 - Plant breeders studying genes influencing leaf...Ch. 7 - In humans, albinism is normally inherited in an...Ch. 7 - a. Seymour Benzers fine structure analysis of the...Ch. 7 - a. You have a test tube containing 5 ml of a...Ch. 7 - Prob. 32PCh. 7 - The rosy ry gene of Drosophila encodes an enzyme...Ch. 7 - Nine rII- mutants of bacteriophage T4 were used in...Ch. 7 - In a haploid yeast strain, eight recessive...Ch. 7 - In Problem 24, you learned that Bloom syndrome is...Ch. 7 - The pathway for arginine biosynthesis in...Ch. 7 - In corn snakes, the wild-type color is brown. One...Ch. 7 - In a certain species of flowering plants with a...Ch. 7 - The intermediates A, B, C, D, E, and F all occur...Ch. 7 - In each of the following cross schemes, two...Ch. 7 - Prob. 42PCh. 7 - The following complementing E. coli mutants were...Ch. 7 - In 1952, an article in the British Medical Journal...Ch. 7 - Mutations in an autosomal gene in humans cause a...Ch. 7 - Antibodies were made that recognize six proteins...Ch. 7 - Prob. 47PCh. 7 - Prob. 48PCh. 7 - In addition to the predominant adult hemoglobin,...Ch. 7 - Most mammals, including New World primates such as...Ch. 7 - Humans are normally trichromats; we have three...
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- Hemophilia is another example of an X-linked disease caused when a recessive allele (Xh) is expressed. If a normal male reproduces with a heterozygous normal female, what are the expected genotypes and phenotypes? Will any of their daughters develop hemophilia?arrow_forwardThe following X-linked recessive traits are found in fruit flies:vermilion eyes are recessive to red eyes, miniature wings are recessiveto long wings, and sable body is recessive to gray body. A cross wasmade between wild-type males with red eyes, long wings, and graybodies and females with vermilion eyes, miniature wings, and sablebodies. The heterozygous female offspring from this cross, whichhad red eyes, long wings, and gray bodies, were then crossed tomales with vermilion eyes, miniature wings, and sable bodies. Thefollowing data were obtained for the F2 generation (including bothmales and females):1320 vermilion eyes, miniature wings, sable body1346 red eyes, long wings, gray body102 vermilion eyes, miniature wings, gray body90 red eyes, long wings, sable body42 vermilion eyes, long wings, gray body48 red eyes, miniature wings, sable body2 vermilion eyes, long wings, sable body1 red eyes, miniature wings, gray bodyA. Calculate the map distances separating the three genes.B. Is…arrow_forwardThe following X-linked recessive traits are found in fruit flies:vermilion eyes are recessive to red eyes, miniature wings are recessiveto long wings, and sable body is recessive to gray body. A cross wasmade between wild-type males with red eyes, long wings, and graybodies and females with vermilion eyes, miniature wings, and sablebodies. The heterozygous female offspring from this cross, whichhad red eyes, long wings, and gray bodies, were then crossed tomales with vermilion eyes, miniature wings, and sable bodies. Thefollowing data were obtained for the F2 generation (including bothmales and females):1320 vermilion eyes, miniature wings, sable body1346 red eyes, long wings, gray body102 vermilion eyes, miniature wings, gray body90 red eyes, long wings, sable body42 vermilion eyes, long wings, gray body48 red eyes, miniature wings, sable body2 vermilion eyes, long wings, sable body1 red eyes, miniature wings, gray bodyWhat information do you know based on the question and your…arrow_forward
- The following X-linked recessive traits are found in fruit flies:vermilion eyes are recessive to red eyes, miniature wings are recessiveto long wings, and sable body is recessive to gray body. A cross wasmade between wild-type males with red eyes, long wings, and graybodies and females with vermilion eyes, miniature wings, and sablebodies. The heterozygous female offspring from this cross, whichhad red eyes, long wings, and gray bodies, were then crossed tomales with vermilion eyes, miniature wings, and sable bodies. Thefollowing data were obtained for the F2 generation (including bothmales and females):1320 vermilion eyes, miniature wings, sable body1346 red eyes, long wings, gray body102 vermilion eyes, miniature wings, gray body90 red eyes, long wings, sable body42 vermilion eyes, long wings, gray body48 red eyes, miniature wings, sable body2 vermilion eyes, long wings, sable body1 red eyes, miniature wings, gray bodyWhat topic in genetics does this question address?arrow_forwardThe following X-linked recessive traits are found in fruit flies:vermilion eyes are recessive to red eyes, miniature wings are recessiveto long wings, and sable body is recessive to gray body. A cross wasmade between wild-type males with red eyes, long wings, and graybodies and females with vermilion eyes, miniature wings, and sablebodies. The heterozygous female offspring from this cross, whichhad red eyes, long wings, and gray bodies, were then crossed tomales with vermilion eyes, miniature wings, and sable bodies. Thefollowing data were obtained for the F2 generation (including bothmales and females):1320 vermilion eyes, miniature wings, sable body1346 red eyes, long wings, gray body102 vermilion eyes, miniature wings, gray body90 red eyes, long wings, sable body42 vermilion eyes, long wings, gray body48 red eyes, miniature wings, sable body2 vermilion eyes, long wings, sable body1 red eyes, miniature wings, gray bodyAnalyze data. Make a drawing. Make a calculation.arrow_forwardOn average, what proportion of X-linked genes in the first individual are the same (inherited from a common ancestor) as those in the second individual? a. A male and his mother b. A female and her mother c. A male and his father d. A female and her father e. A male and his brother f. A female and her sister g. A male and his sister h. A female and her brotherarrow_forward
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