Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 20, Problem 20P

Small population size causes genetic drift because of chance sampling of different alleles from one generation to the next. We can predict how much genetic drift occurs for a given population size using binomial sampling statistics. With a population of size N, we can estimate that 95% of the time the allele frequency (p) in the next generation will be within the confidence interval of p ± 1.96 ( p ( 1 p ) 2 N ) , where p ( 1 p ) 2 N is an estimate of the statistical variance in allele frequencies from one generation to the next with random sampling of 2N alleles each generation.

a. What is the confidence interval for p = 0.5 when N = 100,000?
b. What is the confidence interval for p = 0.5 when N = 10?
c. How are the results in parts (a) and (b) related to the consequences of a population bottleneck?
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An autosomal locus has alleles A and a.  The allele frequencies in a population at Hardy Weinberg equilibrium are p = Freq(A) = 0.5 q = Freq(a) = 0.5 What is the frequency of homozygous wild-type (AA) in this population? Enter a single number between 0 and 1, for example, 0.33
An autosomal locus has alleles A and a.  The allele frequencies in a population at Hardy Weinberg equilibrium are p = Freq(A) = 0.1 q = Freq(a) = 0.9 What is frequency of heterozygotes in this population? Enter a single number between 0 and 1, for example 0.33
Consider an autosomal locus with alleles A and a. If the the allele frequencies are as follows Freq(A) = 0.4, Freq(a) = 0.6. , then what is the predicted frequency of heterozygous Aa individuals, assuming the population is in Hardy-Weinberg equilibrium? Freq(Aa) = ? Enter a number between 0 and 1, inclusive, for example 0.33

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Genetics: From Genes to Genomes, 5th edition

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