Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 20, Problem 30P
In March 2013, the American Journal of Human Genetics published a report that an African-American man who submitted his genome for commercial genealogical analysis had a Y chromosome whose sequence was very different from that of other Y chromosomes that had been characterized previously. The investigators then found that certain males among the Mbo (an ethnic group in Cameroon) shared many of the polymorphisms first found in this African-American man. How do you think these findings would have altered estimates of when a man carrying the MRCA for the human Y chromosome would have lived on the earth?
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a) What gene is in the middle?
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genes b and wx:
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7) Three years later, one of Rocky's and Ruby's sons, who is heterozygous for his curly fur,
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Female Drosophila heterozygous for three recessive mutations e (ebony body), st (scarlet eyes), and ss (spineless bristles) were testcrossed, and the following progeny were obtained: Phenotype Number wild-type 67 ebony 8 ebony, scarlet 68 ebony, spineless 347 ebony, scarlet, spineless 78 scarlet 368 scarlet, spineless 10 spineless 54 (a) What indicates that the genes are linked? (b) What was the genotype of the original heterozygous females? (c) What is the order of the genes? (d) What is the map distance between e and st? (e) Between e and ss? (f) What is the coefficient of coincidence? (g) Diagram the crosses in this experiment.
Chapter 20 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 20 - Choose the best matching phrase in the right...Ch. 20 - When an allele is dominant, why does it not always...Ch. 20 - A population with an allele frequency p of 0.5 and...Ch. 20 - Prob. 4PCh. 20 - Which of the following populations are at...Ch. 20 - A dominant mutation in Drosophila called Delta...Ch. 20 - A large, random mating population is started with...Ch. 20 - Prob. 8PCh. 20 - Prob. 9PCh. 20 - Two hypothetical lizard populations found on...
Ch. 20 - It is the year 1998, and the men and women sailors...Ch. 20 - Prob. 12PCh. 20 - In 1927, the ophthalmologist George Waaler tested...Ch. 20 - Prob. 14PCh. 20 - A gene has two alleles A frequency = p and a...Ch. 20 - Some people can taste the bitter compound...Ch. 20 - Androgenetic alopecia pattern baldness is a...Ch. 20 - Why is the elimination of a fully recessive...Ch. 20 - Tristan da Cunha is a group of small islands in...Ch. 20 - Small population size causes genetic drift because...Ch. 20 - Prob. 21PCh. 20 - A mouse mutation with incomplete dominance t =...Ch. 20 - In Drosophila, the vestigial wings recessive...Ch. 20 - Prob. 24PCh. 20 - You have identified an autosomal gene that...Ch. 20 - In Europe, the frequency of the CF allele causing...Ch. 20 - An allele of the G6PD gene acts in a recessive...Ch. 20 - Explain why evolutionary biologists monitor...Ch. 20 - What is the most straightforward evidence at the...Ch. 20 - In March 2013, the American Journal of Human...Ch. 20 - If you go back 40 generations into your biological...Ch. 20 - In Fig. 21.17, to what part of the world does...Ch. 20 - Predict the DNA sequences at the four nodes...Ch. 20 - A cladogram not drawn to scale for the taxonomic...Ch. 20 - As noted in Fig. 21.22, humans now living in...
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- A sex-linked recessive allele rg causes a red-green colorblindness in humans. A normal woman whose father was colorblind marries a colorblind man. A. What genotypes are possible for the mother of the colorblind man? B. What are the chances that the first child from this marriage will be a colorblind boy? C. Of the girls born from this union, what proportion can be expected to be colorblind? D. Of all the children of these parentsarrow_forwardYou are studying four linked genes located on chromosome 2 in the fruit fly Drosophila melanogaster: adp (which contributes to obesity), b (which contributes to body color), pr (which contributes to metabolism), and vg (which contributes to wing formation). A series of crosses between pair-wise combinations of these mutations yielded the following recombination frequencies between the indicated loci: pr and adp 9% adp and b 6% pr and b 3% vg and b 10% vg and pr 7% What is the genetic distance in map units (cM) between the adp and vg loci? 16 9 6 4arrow_forwardIn flies, long wings are a dominant trait, and short wings are a recessive trait Medium wings are the heterozygous trait. Based on this information, if a homozygous long-winged fly is crossed with another a heterozygous fly, their offspring will have which percentages for long, medium, and short wings? Assume random chromosome segregation. 17) A) 25% long, 75% medium, 0% short B) 50% long, 25% medium, 25% short C) 50% long, 509% medium, 0% short D) 100% medium. 0% long, 0% shortarrow_forward
- Concordance studies of twins for a neurodegenerative disorder show MZ= 46% and DZ= 15%. Further studies have shown a possible link to a gene on chromosome 9, however, there are some individuals in the study who have the allele but do not develop the disorder (group 1), and there are other individuals who do not have the allele yet develop the disorder (group 2). Amita's older sister and maternal uncle have this disorder. Currently, Amita & her 2 younger brothers do not show symptoms. Amita's paternal grandfather was rumored to have this disorder. 1. Draw the pedigree for Amita's family and determine the mode of inheritance if any. 2. Explain how the 2 groups in the study could be possible? 3. What would you tell Amita about the heritability of this disorder?arrow_forwardWhat feature(s) of this pedigree indicate(s) dominant inheritance?arrow_forwardThis pedigree traces the inheritance of a trait in humans. Based on this pedigree, is the allele for this disease dominant or recessive? Is it sex-linked? Explain. What genotypes are most probable for the individuals labeled 4, 7, and 10?arrow_forward
- In the fruit fly, recessive mutations in either of two independently assorting genes, brown and purple, prevent the synthesis of red pigment in the eyes. Thus, homozygotes for either of these mutations have brownish-purple eyes. However, heterozygotes for both of these mutations have dark red, that is, wild-type eyes. If such double heterozygotes are intercrossed, what kinds of progeny will be produced, and in what proportions?arrow_forwardA study of three generations in a family of a male colleague of the authors indicated that many of the man's blood relatives had died of cardiovascular accidents and coronary heart disease. Others died of other causes but were affected by high blood pressure. What are the implications of this information for the man in question? b. What information and help might a genetic counselor provide?arrow_forwardThe following pedigree illustrates the inheritance of Nance–Horan syndrome, a rare genetic condition in which affected people have cataracts and abnormally shaped teeth.arrow_forward
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